Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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1, 1-Dichloroethane
TDI oral
Organisation
UF UF description Study type Description Target organ/Critical
Effect
Reference
Web link
US EPA Provisional
Peer Reviewed
Toxicity Values
(PPRTV)
3000 10 for extrapolation
from a sub chronic
study, 10 interspecies
extrapolation, 10
human variability and
3 for database
deficiencies
Subchronic study on male Sprague-Dawley rats. The rats
were treated with 1,1-dichloroethane doses of 0, 500,
1000, 2000,
or 4000 mg/kg-day by gavage in corn oil, 5 days/week for
13 weeks. Body weights were recorded weekly. Urine was
collected every two weeks from half of the animals in each
dose group for measurement of protein, glucose, and
selected enzyme markers of toxicity (acid phosphatase, N-
acetylglucosaminidase, alkaline phosphatase, and
maltase). Blood was collected from the remaining half of
the animals in weeks 0, 4, 8, and 12 for measurement of
serum enzyme markers of toxicity (alanine
aminotransferase, sorbitol dehydrogenase, ornithinecarbamyl
transferase, and blood urea nitrogen). At study
termination, the liver and kidney were weighed and
assayed for nonprotein sulfhydryl content, and samples
from these organs and the lung, brain, adrenal, stomach,
spleen, testes, and epididymis were collected for
histological examination.
Based on the
transitory and
reversible increase in
urinary enzymes (ACP)
indicative of renal
injury at 8 weeks, the
1000 mg/kg-day dose
was chosen to be a
NOAEL and the 2000
mg/kg-day dose as
LOAEL
Kidneys Muralidhara, S., R.
Ramanathan, S.M.
Mehta et al. 2001.
Acute, subacute, and
subchronic oral
toxicity of 1,1-
dichloroethane in
rats: application to
risk evaluation.
Toxicol. Sci. 64: 134-
145.
-
USEPA-Regional
Screening Level (RSL)
Unknown Unknown Unknown Unknown Unknown EPA’s Provisional Peer
Reviewed Toxicity
Values (PPRTVs)
http://www.epa.gov/r
egion09/superfund/pr
g/pdf/ressoil_sl_table
_run_APRIL2009.pdf
Risk Assessment
Information System
1000 Not given Based on a 13-week inhalation study in rats and route-toroute
extrapolation
Unknown Unknown Tox study by Hofmann
et al., 1971 and
reference from HEAST
(EPA 1993)
http://rais.ornl.gov/to
x/profiles/1_1_dichlor
oethane_f_V1.shtml
Texas Commission on
Environmental
Quality
Unknown Unknown Unknown Unknown Unknown Texas Commission on http://www.tceq.stat
Environmental Quality-e.tx.us/assets/public/r
Clean up standards emediation/rrr/rrrtox
chph_2006.xls
(Page 2 of 4) (EIC proforma 1,1-dichloroethane.xls 28/08/2009)