Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

More documents

Recommendations

Info

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1,2 trichloroethane ID oral Organisation Study type Description Response Reference Web link European Chemicals Bureau (ECB) Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels USEPA Integrated Risk Information System (IRIS) Oral, gavage Technical grade (92.7%) 1,1,2- trichloroethane Hepatocellular carcinoma administered by gavage in corn oil to Osborne- Mendel rats and B6C3F1 mice. 4 groups of 50 (2 sexes x 2 species) given an average of 139 mg.kg-1.d-1 1,1,2-TCA. 4 groups of 50 (2 sexes x 2 species) given an average of 279 mg.kg-1.d- 1 1,1,2-TCA. 4 groups of 20 (2 sexes x 2 species) were used as control. By two statistical tests, treatment of mice was found to be associated with increased incidence of hepatocellular carcinomas. Tumours were found in treated rats that were not found in controls but there was no statistically significant increase in tumour incidence in rats as a function of treatment Meeting of the Commission Working Group on the Classification and Labelling of Dangerous Substances, ECB Ispra, 16-18 January 2002. ECBI/15/02 Rev 3. Kreule P, Swartjes FA (1998) Proposals for Intervention Values for soil and groundwater, including the calculation of the human-toxicological serious soil contamination concentrations: Fourth series of compounds. RIVM rapport 711701005. NCI (National Cancer Institute). 1978. Bioassay of 1,1,2-trichloroethane for possible carcinogenicity. U.S. DHEW Tech. Rep. Ser. 74. Publ. No. NIH 78- 1324. http://ecb.jrc.ec.europa.eu/documents/Classification- Labelling/ADOPTED_SUMMARY_RECORDS/1502r3_sr_CMR0102.pdf http://www.rivm.nl/bibliotheek/rapporten/711701005.pdf. http://www.epa.gov/ncea/iris/subst/0198.htm#quaoral ID inhal Organisation Study type Description Response Reference Web link USEPA Integrated Risk Information System (IRIS) This inhalation risk estimate was calculated from the oral exposure data described in the ID oral section above http://www.epa.gov/ncea/iris/subst/0198.htm#quaoral Page 4 of 4 EIC proforma 1,1,2-trichloroethane 25/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Jeff Thorton Melinda Evans (Firth 1,1,2 trichloroethane CAS 79-00-5 Assessor A: Assessor B: Final review: Panel/SF (Golder Assoc.) Consultants) Date 15/04/2009 Date 29/04/2009 Date 25/08/2009 MDI Recommended MDIoral Units Justification: Value of 0.24 μg.day-1 selected from European study (RIVM). OECD Report is based on a 'worst case' scenario using Japanese data. The 1,1,1-TCA isomer has a TOX report with an oral 0.24 ug day-1 MDI of 0.2 ug/day which is comparable. Value Organisation Date Media Value Units Description Reference Web link IPCS INCHEM 15/04/2009 Drinking water 2.60E+00 ug.day-1 Based on the highest OECD SIDS 1,1,2-trichloroethane SIDS Initial http://inchem.org/ PEC of 1.30 x 10-3 mg/l (1.3 ug.L) ASSUMING 2 L/day Assessment Report, March 2000, section 4.1.3 (http://www.inchem.org/documents/sids/sids/79005.p df) for an adult Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissable Risk (MPR) Levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk Levels Other 14/04/2009 Food and drink 0.24 ug day-1 Study from Germany 1980-1983 Janssen et al. 1998. Maximum Permissible Risk Levels for Human Intake of Soil Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004. March 1998. Page 79. 14/04/2009 Drinking water no data - US Toxicological Profile for 1,1,2-Trichloroethane. December 1989. http://www.atsdr.cdc.gov/toxprofiles/tp148-c5.pdf 06/04/2009 Food and drinking water Rarely encountered 06/04/2009 Drinking water 0.24 Japan: expected quantities of the maximum oral exposure. Suspect units quoted are incorrect should be ug.day-1. - US Technology Transfer Network Air Toxics Web Site. Hazard Summary-Created in April 1992; Revised in January 2000 Japanese Chemical Substances Control Document: 1,1,2-trichloroethane www.rivm.nl/en/ www.atsdr.cdc.gov/ http://epa.gov/ttn/a tw/hlthef/trietha.html http://www.env.go.j p/en/chemi/chemic als/profile_erac/prof ile5/pf1-18.pdf Page 1 of 2 EIC proforma 1,1,2-trichloroethane 25/08/2009
Page 1 and 2:
www.esdat.net Esdat Environmental D
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22: www.esdat.net Esdat Environmental D
Page 71: www.esdat.net Esdat Environmental D
Page 103 and 104: 1,3,5-Trimethylbenzene CAS 108-67-8
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321:
show all

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

Create successful ePaper yourself

Delete template?

Save as template?