Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1,2 trichloroethane TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link International Agency for Research on Cancer (IARC) Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels. Health Canada Toxicological Values Mice subchronic 90 day drinking water study in mice CNS, liver, kidneys Janssen et al. 1998 based on US EPA IRIS (1995). Maximum Permissible Risk Levels for Human Intake of Soil Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004. March 1998. http://www.rivm.nl/bibliotheek/rapporten/711701004.pdf US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Unknown Unknown Neurological end point ATDSR MRL for Hazardous Substances, last updated Dec 2008 http://www.atsdr.cdc.gov/mrls/index.html#bookmark02 Unknown Unknown Hepatic end point ATDSR MRL for Hazardous Substances, last updated Dec 2008 http://www.atsdr.cdc.gov/mrls/index.html#bookmark02 USEPA Integrated Risk Information System (IRIS) Mouse Subchronic Drinking Water Study Mice exposed via drinking water for 90 days, various doses. Liver US EPA IRIS: Sanders, V.M., K.L. White, Jr., G.M. Shopp, Jr. and A.E. http://www.epa.gov/ncea/iris/subst/0198.htm#studoral Munson. 1985. Humoral and cell-mediated immune status of mice exposed to 1,1,2- trichloroethane. Drug Chem. Toxicol. 8(5): 357-372. and White, K.L., Jr., V.M. Sanders, V.W. Barnes, G.M. Shopp, Jr. and A.E. Munson. 1985. Toxicology of 1,1,2-trichloroethane in the mouse. Drug Chem. Toxicol. 8(5): 333-355. US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) USEPA Region 9 PRGs RAIS Adaptive Risk Assessment Modelling System (ARAMS) Texas Commission on Environmental Quality TDI inhal Subchronic mouse study Groups of male and female CD-1 mice (16/sex/group) were exposed to 1,1,2- trichloroethane in the drinking water for 90 days at concentrations of 20, 200, or 2000 mg/L, which the researchers estimated to provide doses of 0, 4.4, 46, and 305 mg/kg-day Liver Sanders, V.M., K.L. White Jr., G.M. Shopp et al. 1985. Humoral and cellmediated immune status of mice exposed to 1,1,2-trichloroethane. Drug Chem. Tox. 8: 357-372. AND White, K.L. Jr., V.M. Sanders, D.W. Barnes et al. 1985. Toxicology of 1,1,2-trichloroethane in the mouse. Drug Chem. Tox. 8: 333-355. Not available online. Document reference: US EPA (2006). Provisional Peer Reviewed Toxicity Values for 1,1,2-Trichloroethane (CASRN 79-00-5), Derivation of a Subchronic Oral RfD, Superfund Health Risk Technical Support Center, National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH 45268. for males and 0, 3.9, 44, and 384 mg/kg-day for females (White et al., 1985; Sanders et al., 1985). No data No data No data No data http://www.epa.gov/region09/superfund/prg/pdf/master_sl_table_bwru n_APRIL2009.pdf No data Mouse Clinical serum chemistry http://rais.ornl.gov/cgi-bin/tox/TOX_select White et al. (1985) No data No data No data No data No data No data No data No data No data http://www.tceq.state.tx.us/remediation/trrp/trrppcls.html Organisation Study type Description Response Reference Web link International Agency for Research on Cancer (IARC) Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels Multiple species, subchronic 6 month study on several species CNS, liver, kidneys Janssen et al. 1998 based on Dow (1981). Maximum Permissible Risk Levels for Human Intake of Soil Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004. March 1998. http://www.rivm.nl/bibliotheek/rapporten/711701004.pdf Page 2 of 4 EIC proforma 1,1,2-trichloroethane 25/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1,2 trichloroethane CAS Number: 79-00-5 Assessor A: J Thornton, Golder Assessor B: M Evans, Firth Final review: Panel/SF Associates Consultants Date 15/04/2009 Date 29/04/2009 Date 25/08/2009 ID oral Recommended IDoral Units n/a Justification Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen Organisation Web Link Last Updated Date Web Checked Non threshold effects European Chemicals Bureau (ECB) http://ecb.jrc.it/ 15/04/2009 Carcinogenic Category 3 Basis Health criteria type Value Units Confidence rating Basis Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels http://www.rivm.nl/en/ USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ Verification Date — 07/23/1986 15-Apr-09 C - Possible human carcinogen Hepatocellular carcinomas and pheochromocytomas in one strain of mice forms the basis for this classification. Carcinogenicity was not shown in rats. 1,1,2- Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen Oral slope factor 5.70E-02 (mg.kg-1.d-1)-1 Dose-related increases in hepatocellular carcinomas were observed in adequate numbers or mice of both sexes. Background incidence of this tumour type is generally high. Modelling was done on only one data set. Extrapolation Method — Linearized multistage procedure, extra risk ID inhal Recommended IDinhal Units n/a Justification Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen Organisation Web Link Last Updated Date Web Checked Non threshold Basis Health criteria Value Units effects type USEPA Integrated Risk Information System http://epa.gov/iris/ Verification Date — 15-Apr-09 Inhalation unit risk 1.60E-05 (μg.m-3)-1 (IRIS) 07/23/1986 Confidence rating Dose-related increases in hepatocellular carcinomas were observed in adequate numbers or mice of both sexes. Background incidence of this tumour type is generally high. Modelling was done on only one data set. Basis Extrapolation Method — Linearized multistage procedure, extra risk Page 3 of 4 EIC proforma 1,1,2-trichloroethane 25/08/2009
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