Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Substance: Molybdenum CAS Number: 7439-98-7 Assessor A: N Struggles, AECOM Assessor B: Atkins Final review: Panel/SF Chemical Formula: Mo Phase at Ambient Solid (Metal) Tempertaure Date: 02-Jun-09 Date: 17-Jun-09 Date: 26-Aug-09 http://srdata.nist.gov/solubility/ http://webbook.nist.gov/chemistry/ A B C D E F G Property Units Calculated Value Adopted Value Ref. Temp (C) Rationale References HOWARD, 1990 LIDE, 2008 MACKAY et al, 2006 MERCK, 2006 MONTGOMERY, 2007 MONTGOMERY, 1997 NIST, 2005 Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Source Units SR7 Units Source Units SR7 Units Source Units SR7 Units Source Units SR7 Units Source Units SR7 Units (C) (C) (C) (C) (C) (C) Required Parameters Solubility (S) 10 oC where possible. (Use unit converter if source provides different units) mg/L n/a 8.40E+05 25 Highes value located, for sodium molybdenate http://cs3-hq.oecd.org/scripts/hpv/ H ADDITIONAL REFERENCES OECD, 2000 INCHEM Ref. Temp Source Units SR7 Units (C) Source Units SR7 Units mg/L mg/L Ref. Temp (C) g/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) Geomean Insert Values Insert Values Insert Values 0.00E+00 0.00E+00 Insert Values Insert Values Insert Values 8.40E+05 8.40E+05 8.40E+05 5.00E+01 5.00E+01 Ref. Temp (C) Soil Water Partition Coefficient Soil-to-plant concentration factor - Green Vegetables Soil-to-plant concentration factor - Root Vegetables Soil-to-plant concentration factor - Tuber Vegetables Soil-to-plant concentration factor - Herbaceous Fruit Soil-to-plant concentration factor - Shrub Fruit Soil-to-plant concentration factor - Soil-Plant availability correction factor Root-shoot, root-root store, root -tuber and root to fruit correction factors cm 3 .g -1 mg kg–1 FW plant per mg kg–1 DW soil mg kg–1 FW plant per mg kg–1 DW soil mg kg–1 FW plant per mg kg–1 DW soil mg kg–1 FW plant per mg kg–1 DW soil mg kg–1 FW plant per mg kg–1 DW soil mg kg–1 FW plant per mg kg–1 DW soil NA n/a n/a NA n/a n/a NA n/a n/a NA n/a n/a NA n/a n/a NA n/a n/a Dimensionless NA n/a n/a Dimensionless NA n/a n/a Dermal Absorption factor Dimensionless NA 0 n/a Soil to dust transport factor Dimensionless NA 0.5 n/a NA NA No data found - though not required for for land uses without plant uptake being modelled by EIC Source: SR3 for metals in absence of other data Source: SR3 in absence of other data Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Ref. Temp Dimensionless Dimensionless Ref. (C) Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Dimensionless Temp (C) (C) (C) (C) (C) (C) (C) (C) Average Insert Values n/a Insert Values n/a Insert Values n/a Insert Values n/a Insert Values n/a Insert Values n/a Insert Values n/a Insert Values n/a Insert Values n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Page 1 of 1 EIC proforma molybdenum.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 1,1,2 trichloroethane CAS Number: 79-00-5 Assessor A: J Thornton, Golder Assessor B: M Evans, Firth Final review: Panel/SF Associates Consultants Date 15/04/2009 Date 29/04/2009 Date 25/08/2009 Apply TDIoral to exposure routes Apply IDoral to exposure routes Apply TDIinh to exposure routes Apply IDinh to exposure routes Oral Dermal Inhalation Combine Oral and Inhalation TDIs Yes Yes No No No No No No Yes No No No No Justification Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen - TDIoral applied to oral and dermal routes Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen- TDIinh applied to inhalation route TDI oral Recommended TDIoral Units 4 ug.kg-1.d-1 Justification USEPA IRIS and RIVM (chronic) value used. It is noted that the USEPA PPRTV is more recent, although it is a sub-chronic RfD and provisional. Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description 1.d-1 International Agency for Research on Cancer (IARC) http://inchem.org/pages/iarc.html 15/04/2009 Classified Class 3: TDI Dutch National Institute for Public Health http://www.rivm.nl/en/ 1996 15/04/2009 Maximum 4 ug.kg-1.d-1 4 Provisional value - NOAEL 3.9 mg.kg-1.day-1 1000 10 x interspecies, 10 x intraspecies, and the Environment (RIVM) Maximum Permissible Risk (MPR) levels. permissible risk level (MPR) same as TDI MUCH UNCERTAINTY 10 subchronic not chronic study Health Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html Unknown 15/04/2009 No Health based criteria, Not a priority contaminant US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) http://www.atsdr.cdc.gov/ Dec-89 15/04/2009 Minimal Risk Level acute exposure 0.3 mg.kg-1.day-1 300 Final Unknown Unknown Unknown 100 Unknown Dec-89 15/04/2009 Minimal Risk Level intermediate exposure 0.04 mg.kg-1.day-1 40 Final Unknown Unknown Unknown 100 Unknown http://epa.gov/iris/ Feb-95 15/04/2009 RfD 0.004 mg.kg-1.day-1 4 Medium NOAEL 3.9 mg.kg-1.day-1 1000 10 x interspecies, 10 x intraspecies, 10 subchronic not chronic study US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml 17-10-2006 29-07-2009 p-sRfD (provisional sub-chronic reference dose) 0.0039 mg.kg-1.day-1 3.9 Low NOAEL 3.9 mg/kg-day 1000 10 for extrapolation from mice to humans, 10 for protection of sensitive individuals, and 10 for deficiencies in the database USEPA Region 9 PRGs RAIS Adaptive Risk Assessment Modelling System (ARAMS) Texas Commission on Environmental Quality TDI inhal http://www.epa.gov/region09/superfund/p rg/index.html Apr-09 26/05/2009 RfDo 0.004 mg.kg-1.day-1 4 No data No data No data No data No data No data http://rais.ornl.gov/homepage/rap_tool.sht 1985 26/05/2009 RfDo 0.004 mg.kg-1.day-1 4 Medium NOAEL/LOAEL No data No data 1000 No data ml http://el.erdc.usace.army.mil/arams/ Links to IRIS and RAIS 26/05/2009 No data No data No data No data No data No data No data No data No data No data http://www.tceq.state.tx.us/remediation/rr r.htm No data 26/05/2009 RfDo 0.004 mg.kg-1.day-1 4 No data No data No data No data No data No data Recommended TDIinhal Units 4.85 ug.kg-1.d-1 Justification Only data available (RIVM) Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description 1.d-1 International Agency for Research on Cancer (IARC) http://inchem.org/pages/iarc.html 15/04/2009 Classified Class 3: TDI Dutch National Institute for Public Health http://www.rivm.nl/en/ March 1998 15/04/2009 Maximum 17 ug.m-3 4.857142857 Provisional value - NOAEL 82 mg/m3 1000 10 x interspecies, 10 x intraspecies, and the Environment (RIVM) Maximum Permissible Risk (MPR) levels permissible risk level (MPR) same as TDI MUCH UNCERTAINTY 10 subchronic not chronic study Page 1 of 4 EIC proforma 1,1,2-trichloroethane 25/08/2009
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