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Molybdenum CAS 7439-98-7 Assessor A: Nick Struggles, AECOM Assessor B: Atkins Final review: Panel/SF
Date 01/06/2009 Date 17/06/2009 Date 26/08/2009
MDI Recommended MDIoral Units
134.8 ug day-1 per day). MDIoral is sum of contributions from diet and drinking water.
Organisation Date Media Value Units Description Reference Web link
Food Standards Agency
01/05/2009 mean dietary
exposure for adults
a) estimated 0.123-0.125
b) mean for adults 1.61-1.64
c) toddlers mean 4.8-4.87
d) young people mean 3.01-
3.05
a) mg/day
b), c) , d) ug/kg
bw/day
Justification: Mean daily intake for adults in food from FSA (1.64 ug/kg.bw/day), equivalent to 114.8μg/day assuming a 70kg adult.
WHO notes concentration of Mo in drinking water are typically less than 0.01mg/L (equivalent to 0.02 mg/day for 2L consumed
This is slightly higher than the exposure
reported in 1994 and 1991 and 1985
(0.11mg/day). These are well within the
guidance level for molybdenum of
0.23mg/day as stated in the EVM report and
the WHO estimated daily requirement for
molybdenum of 0.1-0.3mg/day for adults.
The mean dietary exposure for adults was
estimated to be 1.61-1.64ug/kg/bw and the
high level exposure was 3.03-3.08
ug/kg/bw/day. Estimated intake in toddlers
mean (4.8-4.87ug/kg/bw/day) and high level
(7.54-8.32ug/kg/bw/day) and for young
people mean (3.01-3.05ug/kg/bw/day) and
high level (5.77-5.82ug/kg/bw/day).
Page 15. MEASUREMENT OF THE
CONCENTRATIONS OF METALS AND
OTHER ELEMENTS
FROM THE 2006 UK TOTAL DIET STUDY
January 2009
http://www.food.gov.uk/multimedia/pdfs/
fsis0109metals.pdf
Committee on Toxicity of
Chemicals in Food, Consumer
Products and the Environment
(COT)
01/05/2009 a) and b) food dietary
intake
c) max recommended
level in drinking
water
d) WHO noted typical
drinking water
concentration
e) Recommended
daily requirement of
Mo
f) drinking water
g) supplements
h) Estimated
maximum intake
a) 0.11mg (mean)
b) 0.21mg (97.5%ile)
c) 0.07
d) 0.01
e) 0.1-0.3
f) 0.02
g) up to 0.33mg
h) 0.21+0.02+0.33=0.56
a) and b) mg
c) and d) mg/L
e) mg/day for
adults
f) mg/day
g) mg
h) mg/day
a) and b) Daily exposure estimates from food
Source of data sources, excluding
supplements, for men and women (in mg).
Mean and 97.5%ile values presented.
c) WHO recommended max level of Mo in
drinking water
d) WHO notes that the concentrations of Mo
in drinking water are typically less than
0.01mg/L, however, in areas near mining
sites, Mo concentrations up to 0.2mg/L have
been reported.
e) WHO 1993 estimated daily requirement
for molybdenum for adults
f) drinking water - (estimated from 0.01mg/L
(WHO 1993)
g) supplements
h) estimated maximum intake (totalled from
food (97.5%ile see a), drinking water (see f)
and maximum recommended supplements
(see g)
a) and b) MAFF 1997. quoted in Safe http://cot.food.gov.uk/pdfs/vitmin2003.pd
Upper Limit on Vitamins and Minerals f
(May 2003)
http://cot.food.gov.uk/pdfs/vitmin200
3.pdf
c), d), e), f), g),
h)http://cot.food.gov.uk/pdfs/vitmin20
03.pdf
European Food Safety Authority
(EFSA)
01/05/2009 Estimated dietary
exposure (food and
drink)
50-400 (mean 128) ug day-1 Estimated Dietary exposure for Adults in UK. SCF 1993 study in EFSA 'Tolerable
Upper Intake Levels for Vitamins and
Minerals' 2006.
http://www.efsa.europa.eu/cs/BlobSer
ver/Scientific_Document/upper_level_
opinions_full-part33.pdfssbinary=true
www.efsa.europa.eu/en.htm
Scientific Committee on Food
(SCF) pre 2002
01/05/2009 mean dietary intake 128 ug/day Mean dietary intake in the United Kingdom Previous source: SCF 1993 .
Commission of the European
Communities. Reports of the Scientific
Committee for Food (thirty-first series).
Nutrient and energy intakes for the
European Community. Opinion
Expressed on 11 December 1992.
http://ec.europa.eu/food/fs/sc/scf/out
89.pdf
http://ec.europa.eu/fppd/fs/sc/scf/index_e
n.html
Original source: Mills CF, Davis, GK.
1987. Molybdenum. In: Mertz W, ed.
Trace Elements in Human and Animal
Nutrition. 5th Ed. Vol 1. San Diego:
Academic Press, 429-463.
Page 1 of 2 EIC proforma molybdenum.xls 26/08/2009