Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 TDI inhal Molybdenum CAS Number: 7439-98-7 Assessor A: Nick Struggles, Assessor B: Atkins Final review: Penl/SF AECOM Date 01/06/2009 Date 17/06/2009 Date 26/08/2009 Recommended TDIinhal Units 3.43 ug.kg-1.d-1 Justification RIVM values chosen. If any of the HSE values were chosen it would be necessary to apply additional Uncertainty Factors which is out with the scope of this work. Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description Study type Description 1.d-1 Health and Safety Executive (HSE) http://www.hse.gov.uk/ No data 30/06/1905 a) 5 b) 10 c) 10 d) 20 mg/m3 Workplace exposure limit. This list is legally binding, as it reproduces the list of workplace exposure limits (WELs) which have been approved by the Health and Safety Commission a) Long-term exposure (8-hour TWA limit reference period) - soluble b) Long-term exposure (8-hour TWA limit reference period) - insoluble c) Short-term exposure limit (15minute reference period) - soluble d) Short-term exposure limit (15minute reference period) - insoluble WHO Guidelines for drinking water Quality http://www.who.int/water_sanitation_healt h/dwq/guidelines/en No data 01/06/2009 Human intake of airborne molybdenum is not likely to be a major exposure pathway Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels http://www.rivm.nl/en/ 01/03/2001 01/06/2009 TCA 12 ug.m-3 3.43 ( 12 ug.m3 x 20m3/day / 70kg ) Low NOAEC 100 mg.m-3 1000 Factor of 100 for inter- and intraspecies extrapolation and 10 for semi chronic to chronic exposure semi chronic NTP 1997 Study of inhalation of molybdenum trioxide in rats and mice, only effect on body weight was noticed at 300 mg.m-3. After 2 year inhalation exposure of 30 mg.m-3. Concluded changes are similar to other inhalation studies of particulate compounds and not caused by the molybdenum trioxide. ID oral Recommended IDoral None Units Justification Insufficient data Organisation Web Link Last Updated Date Web Checked Non threshold effects Basis Health criteria type Value Units Confidence rating Basis Study type Description ID inhal Recommended IDinhal None Units Justification Insufficient data Organisation Web Link Last Updated Date Web Checked Non threshold effects Basis Health criteria type Value Units Confidence rating Basis Study type Description Page 3 of 4 EIC proforma molybdenum.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Molybdenum TDI inhal Organisation Response Reference Web link Health and Safety Executive (HSE) not mentioned EH40/2005 Workplace exposure limits. Table 1: List of approved workplace exposure limits (as consolidated with amendments October 2007) http://www.hse.gov.uk/coshh/table1.pdf WHO Guidelines for drinking water Quality Chappell WR. Transport and biological effects of molybdenum in the environment in: WHO 2996 'Molybdenum in Drinking-water Background document for development of WHO Guidelines for Drinking-water Quality http://www.who.int/water_sanitation_health/dwq/chemicals/molybdenum. pdf Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels Inflammatory Lesions Baars et al. 2001 'Re-evaluation of human-toxicological maximum permissible risk levels' RIVM report 711701 025. ID oral Organisation Response Reference Web link ID inhal Organisation Response Reference Web link Page 4 of 4 EIC proforma molybdenum.xls 26/08/2009
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