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Trans-1,2-dichloroethene CAS 156-60-5 Assessor A: Nick Brown Grontmij Assessor B Catherine Helm WD Environmental Final Review Panel/SF
Date 29/05/2009 Date 01/06/2009 Date 28/08/2009
MDI
Recommended
MDIoral
Units
4 ug day-1
Only US Data has been identified. In the majority of cases exposure through drinking water and food is likely to be negligible however
sources in drinking water have been identified. A value of 4ug day-1 for background exposure through drinking water is tentatively
proposed within the WHO Background document for development of WHO Guidelines for Drinking Water Quality. This value appears to
be based on the US study that identified detectable concentrations in 8% of drinking water sources with detectable concentrations
ranging between 2-120ug/l. In conjunction with the MDI Inhalation (6ug day-1 see below) this equates to a total of 10ug/day background
exposure which conforms reasonably well with the RIVM estimate of total background exposure to the mixed isomers of 0.13ug/kgbw/day
(9.1ug/day for a 70kg adult). The same value has also been selected for the cis isomer since the primary study does not
distinguish between the two isomers.
Organisation Date Media Value Units Description Reference Web link
International Porgramme on Chemical 14/04/2009 See WHO Guidelines for See WHO Guidelines
See WHO Guidelines for DWQ
http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf
Safety (IPCS)
DWQ
for DWQ
Joint Expert Committee on Food
Additives (JEFCA)
WHO Guidelines for Drinking Water
Quality
14/04/2009 See WHO Guidelines for
DWQ
See WHO Guidelines
for DWQ
See WHO
Guidelines for
DWQ
See WHO
Guidelines for
See WHO Guidelines for DWQ
DWQ
14/04/2009 Drinking water 4 ug/day 1,2 dichloroethene (mixed isomers) detected in 8% of drinking
supplies derived from groundwater, at concentrations between
2-120ug/l. The high end value is therefore greatly atypical with
the majority of drinking water containing concentrations less
than detection levels. Estimated 4ug/l MDI is based on a
concentration of 2ug/l in drinking water.
WHO (2003) 1,2-Dichloroethene in drinking-water. Background document
for preparation of WHO Guidelines for drinking-water quality.
Geneva,World Health Organization, (WHO/SDE/WSH/03.04/72)
WHO (2003) 1,2-Dichloroethene in drinking-water. Background document
for preparation of WHO Guidelines for drinking-water quality.
Geneva,World Health Organization, (WHO/SDE/WSH/03.04/72)
WHO (2003) 1,2-Dichloroethene in drinking-water. Background document
for preparation of WHO Guidelines for drinking-water quality.
Geneva,World Health Organization, (WHO/SDE/WSH/03.04/72)
http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf
http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf
Dutch National Institute for Public
Health and the Environment (RIVM)
Maximum Permissable Risk (MPR)
Levels
14/04/2009 Drinking water 0-120 ug/l Dutch data not available. 1,2 dichloroethene (mixed isomers)
detected in 8% of drinking supplies derived from groundwater,
at concentrations between 2-120ug/l.. RIVM estimated
background exposure of 0.13ug/kg-bw/day for the mixed
isomers via inhalation and oral intake.
RIVM Report 711701 025. Re-evaluation of human toxicological maximum
permissable risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M.
Hesse, M.E. van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker
March 2001
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf
US Agency for Toxic Substances and
Disease Registry (ATSDR)
Toxicological Profiles and Minimal
Risk Levels
14/04/2009 Drinking water 0-120 ug/l 1,2 dichloroethene (mixed isomers) detected in 8% of drinking
supplies derived from groundwater, at concentrations between
2-120ug/l. The high end value is atypical with the majority of
drinking water containing concentrations less than detection
levels.
Toxicological Profile for 1,2-Dichloroethene, ATSDR, 1996
http://www.atsdr.cdc.gov/toxprofiles/tp87.pdf
USEPA Health Advisories 14/04/2009 DW 0.07 mg/l MCLG & MCL www.epa.gov/waterscience/criteria/drinking/
Toxicological Data Network (TOXNET) 14/04/2009 ND to 2,277 ug/l ADI from water in HSDB Database (trans isomer specific)
http://toxnet.nlm.nih.gov/
USEPA; National Contaminant Occurrence Database. trans-1,2-Dichloroethylene. Available from the
Database Query page at http://www.epa.gov/safewater/data/ncod.html as of Apr 12, 2001.
MDI
Recommended
MDIinh
Units
Only US Data has been identified. The value of 6ug/day is the maximum concentration (for mixed isomers) within range that ATSDR
suggest that the general US population is likely to be exposed to. In conjunction with the MDI Oral (4ug day-1 see below) this equates to a
total of 10ug/day background exposure which conforms reasonably well with the RIVM estimate of total background exposure to the
mixed isomers of 0.13ug/kg-bw/day (9.1ug/day for a 70kg adult). The same value has also been selected for the Cis isomer since ATSDR
6 ug day-1
do not distinguish between the two isomers.
Organisation Date Media Value Units Description Reference Web link
Joint Expert Committee on Food
14/04/2009 See WHO Guidelines for See WHO Guidelines See WHO See WHO Guidelines for DWQ See WHO Guidelines for DWQ http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf
Additives (JEFCA)
DWQ
for DWQ
Guidelines for
WHO Guidelines for Drinking Water
Quality
14/04/2009 Urban and suburban air 644 (Based on 20m3 x
32.2ug/m3)
ug/day
http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf
1,2 Dichloroethene (mixed isomers) recorded at mean
concentrations of 32.2ug/m3 within indoor air (Data source
unclear).
WHO (2003) 1,2-Dichloroethene in drinking-water. Background document
for preparation of WHO Guidelines for drinking-water quality.
Geneva,World Health Organization, (WHO/SDE/WSH/03.04/72)
Dutch National Institute for Public
Health and the Environment (RIVM)
Maximum Permissable Risk (MPR)
Levels
US Agency for Toxic Substances and
Disease Registry (ATSDR)
Toxicological Profiles and Minimal
Risk Levels
14/04/2009 Urban and suburban air 0.27 (Cis isomer) No
background
concentration is
provided for Trans in
air
ug/m3
Dutch data not available. RIVM estimated background exposure
of 0.13ug/kg-bw/day for the mixed isomers via inhalation and
oral intake.
14/04/2009 Ambient air 6 ug/day The general population (USA) estimated to be exposed to low
levels of 1,2 dichloroethene (mixed isomers) through inhalation
in urban air (1-6ug/day)
RIVM Report 711701 025. Re-evaluation of human toxicological maximum
permissable risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M.
Hesse, M.E. van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker
March 2001
Toxicological Profile for 1,2-Dichloroethene, ATSDR, 1996
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf
http://www.atsdr.cdc.gov/toxprofiles/tp87.pdf
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EIC Proforma Trans 1,2 Dichloroethene.xls28/08/2009