Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Trans 1,2 Dichloroethene<br />
TDI oral<br />
Organisation<br />
International Programme on Chemical Safety<br />
(IPCS)<br />
Study type Description Target organ/Critical Effect Reference Web link<br />
Barnes 90 day CD1 CD1 Mice received trans-1,2-dichloroethene in Increased serum alkaline phosphate levels in WHO (2003) 1,2-Dichloroethene in drinking-water. Background document <strong>for</strong> http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf<br />
mice study using the drinking water. Dose groups of 17, 175 and 387 mg/kgbw/day.<br />
No effects at 17mg/kg-bw/day<br />
<strong>Human</strong> effects include CNS depression, Organization, (WHO/SDE/WSH/03.04/72) Primary study - Barnes<br />
males and decreased thymus weight in females. preparation of WHO Guidelines <strong>for</strong> drinking-water quality. Geneva,World <strong>Health</strong><br />
trans isomer<br />
neurological effects and trans is estimated to be DW et al. 1985. Toxicology of trans-1,2-dichloroethylene in the mouse. Drug Chemistry<br />
2x more potent than cis isomer<br />
and toxicology, 1985, 8:373-407<br />
Joint Expert Committee on Food Additives (JECFA)<br />
Barnes 90 day CD1<br />
mice study using the<br />
trans isomer<br />
CD1 Mice received trans-1,2-dichloroethene in<br />
drinking water. Dose groups of 17, 175 and 387 mg/kgbw/day.<br />
No effects at 17mg/kg-bw/day<br />
Increased serum alkaline phosphate levels in<br />
males and decreased thymus weight in females.<br />
<strong>Human</strong> effects include CNS depression,<br />
neurological effects and trans is estimated to be<br />
2x more potent than cis isomer<br />
WHO (2003) 1,2-Dichloroethene in drinking-water. Background document <strong>for</strong> http://www.who.int/water_sanitation_health/dwq/1,2-Dichloroethene.pdf<br />
preparation of WHO Guidelines <strong>for</strong> drinking-water quality. Geneva,World <strong>Health</strong><br />
Organization, (WHO/SDE/WSH/03.04/72) Primary study - Barnes<br />
DW et al. 1985. Toxicology of trans-1,2-dichloroethylene in the mouse. Drug Chemistry<br />
and toxicology, 1985, 8:373-407<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and the<br />
Environment (RIVM) Maximum Permissible <strong>Risk</strong><br />
(MPR) levels<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
USEPA Acute Guideline Levels (AEGLs)<br />
Barnes 90 day<br />
mouse drinking<br />
water study<br />
Barnes 90 day<br />
mouse drinking<br />
water study<br />
CD1 Mice received trans-1,2-dichloroethene in Increased serum alkaline phosphate levels in RIVM Report 711701 025. Re-evaluation of human toxicological maximum permissable http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf<br />
drinking water. Dose groups of 17, 175 and 387 mg/kgbw/day.<br />
males and decreased thymus weight in females. risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M. Hesse, M.E. van Apeldoorn,<br />
No effects at 17mg/kg-bw/day<br />
M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker March 2001 Primary<br />
study - Barnes DW et al. Toxicology of trans-1,2-dichloroethylene in the mouse. Drug<br />
Chemistry and toxicology, 1985, 8:373-407<br />
CD1 Mice received trans-1,2-dichloroethene in Hepatic ATSDR Minimum <strong>Risk</strong> Levels December 2008 and Toxicological Profile <strong>for</strong> 1,2- http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_mrls_december_2008.pdf<br />
drinking water. Dose groups of 17, 175 and 387 mg/kgbw/day.<br />
Dichloroethene, ATSDR, 1996 available at<br />
No effects at 17mg/kg-bw/day<br />
http://www.atsdr.cdc.gov/toxprofiles/tp87.pdf (Primary Reference <strong>for</strong> the Study:<br />
Barnes, D.W., V.M. Sanders, K.L. White, Jr., et al. 1985. Toxicology of trans-1,2-<br />
dichloroethylene in the mouse. Drug Chem. Toxicol. 8: 373-392.)<br />
USEPA <strong>Health</strong> Advisors<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System (IRIS)<br />
Toxicology Data Network (Toxnet)<br />
Barnes 90 day<br />
mouse drinking<br />
water study<br />
CD1 Mice received trans-1,2-dichloroethene in Increased serum alkaline phosphate levels in Barnes, D.W., V.M. Sanders, K.L. White, Jr., et al. 1985. Toxicology of trans-1,2-<br />
drinking water. Dose groups of 17, 175 and 387 mg/kgbw/day.<br />
No effects at<br />
males and decreased thymus weight in females. dichloroethylene in the mouse. Drug Chem. Toxicol. 8: 373-392.<br />
17mg/kg-bw/day<br />
See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above<br />
http://toxnet.nlm.nih.gov/cgi-bin/sis/search<br />
TDI inhalation<br />
Organisation<br />
Study type Description Target organ/Critical Effect Reference Web link<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and the<br />
Environment (RIVM) Maximum Permissible <strong>Risk</strong><br />
(MPR) levels<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
Freundt Semichronic<br />
inhalation<br />
study on Rats<br />
Freundt Semichronic<br />
inhalation<br />
study on Rats<br />
Rats exposed to 780mg/m3 <strong>for</strong> 8 hours a day, 5 days<br />
a week <strong>for</strong> 8 or 16 weeks. 780mg/kg equivalent to<br />
185mg/m3 after adjustment <strong>for</strong> continuous exposure -<br />
this is an LOAEL<br />
Rats exposed to 780mg/m3 <strong>for</strong> 8 hours a day, 5 days<br />
a week <strong>for</strong> 8 or 16 weeks. 780mg/kg equivalent to<br />
185mg/m3 after adjustment <strong>for</strong> continuous exposure -<br />
this is an LOAEL<br />
Liver (degeneration of liver lobules and Kupffer<br />
Cells) and lungs (pulmonary hyperaemia,<br />
alveolal septal distention and pneumonic<br />
infiltration) were effected<br />
Liver (degeneration of liver lobules and Kupffer<br />
Cells) and lungs (pulmonary hyperaemia,<br />
alveolal septal distention and pneumonic<br />
infiltration) were effected<br />
RIVM Report 711701 025. Re-evaluation of human toxicological maximum<br />
permissable risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M. Hesse, M.E.<br />
van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker March 2001<br />
(Primary Study: Freundt et al. 1977. Toxicity Studies on trans-1,2-dichloroethylene.<br />
Toxicology 7, 141-153)<br />
Primary Study: Freundt et al. 1977. Toxicity Studies on trans-1,2-dichloroethylene.<br />
Toxicology 7, 141-153<br />
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf<br />
http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_mrls_december_2008.pdf<br />
US EPA Provisional Peer Reviewed Toxicity Values<br />
(PPRTV)<br />
Freundt Semichronic<br />
inhalation<br />
study on Rats<br />
Rats exposed to 780mg/m3 <strong>for</strong> 8 hours a day, 5 days<br />
a week <strong>for</strong> 8 or 16 weeks. 780mg/m3 equivalent to<br />
185mg/m3 after adjustment <strong>for</strong> continuous exposure -<br />
this is an LOAEL<br />
Liver (degeneration of liver lobules and Kupffer<br />
Cells) and lungs (pulmonary hyperaemia,<br />
alveolal septal distention and pneumonic<br />
infiltration) were effected<br />
Provisional Peer Reviewed Toxicity Values <strong>for</strong> cis-1,2-dichloroethylene, Superfund<br />
<strong>Health</strong> <strong>Risk</strong> Technical Support Centre <strong>for</strong> Environmental <strong>Assessment</strong>, 2006. (Primary<br />
Study: Freundt et al. 1977. Toxicity Studies on trans-1,2-dichloroethylene. Toxicology<br />
7, 141-153)<br />
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EIC Pro<strong>for</strong>ma Trans 1,2 Dichloroethene.xls28/08/2009