Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

More documents

Recommendations

Info

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Styrene TDI inhal Organisation Description Response Reference Web link Health Protection Agency (HPA) Long term human exposure to Styrene HPA Compendium of Chemical Hazards, Styrene. JC Wakefield, HPA 2008 reported to cause subtle changes in hearing, balance, colour vision, psychological performance and asthma http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1202115635291 Health Protection Agency (HPA) Health Protection Agency (HPA) Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels Minor effects on the central nervous system observed in humans exposed to 107mg/m3 of styrene for a period of several years. 107mg/m3 can be converted to 26mg/m3 to account for continuous exposure Liver Weight, Serum Enzyme Levels and neurological effects RIVM Report 711701 025. Re-evaluation of human toxicological maximum permissible risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M. Hesse, M.E. van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker March 2001 (Primary Reference given as: Toxicological Profile for Styrene, ATSDR 1992) http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf Health Canada Toxicological Values Offspring exposed to 60 to 293 ppm for 6 hrs/day during days 7 to 21 days of gestation Reduced weight of offspring Primary Reference: Kishi et al. 1992a, 1992b http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1- lsp1/stryene/styrene_3-eng.php US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) Toxicology Data Network (Toxnet) Analysis of data recorded from several studies Choice Reaction Time and Colour including Kishi et al. (2001) and Mutti et al. (1984) Recognition Styrene occupational exposure was assessed by the authors to correspond to air concentrations ranging from 10-300 ppm as a mean daily exposure. ATSDR, Toxicological Profile for Styrene. Draft for Public Comment. September 2007 Primary Study Reference: Benignus et al. 2005, Human neurobehavioral effects of long-term exposure to Styrene: a Meta-analysis. Environmental Health Perspect 113: 532-538 http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_mrls_december_2008.pdf neuropsychological Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini. 1984. http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~crTanp:1 Exposure-effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am. J. Ind. Med. 5: 275- 286. as IRIS as IRIS as IRIS as IRIS Page4 of 4 EIC Proforma styrene.xls28/08/2009]
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Styrene CAS 100-42-5 Assessor A: Nick Brown Grontmij Assessor B: Catherine Helm WD Environmental Final Review Panel/SF Date 29/05/2009 Date 01/06/2009 Date 28-Aug-09 MDI Recommended MDIoral Units 1 ug day-1 Justification: Value selected is the average intake predicted by the Styrene Working Group (in 1983) (JECFA). Value is UK specific and considered likley to be conservative. Organisation Date Media Value Units Description Reference Web link Health Protection Agency 31/03/2009 Exposure from residues in plastics & natural environment likely to be extremely low. Most exposure in workplace. http://www.who.int/water_sani tation_health/dwq/chemicals/st yrene.pdf European Chemicals Bureau (ECB) Joint Expert Committee on Food Additives (JECFA) 31/03/2009 Drinking Water nd to 0.25 & 0.1, 0.3, 0.5 Plastic-wrapped food
Page 1 and 2:
www.esdat.net Esdat Environmental D
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
1,3,5-Trimethylbenzene CAS 108-67-8
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212:
Page 213 and 214:
Page 215 and 216:
Page 217 and 218:
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252: www.esdat.net Esdat Environmental D
Page 301: www.esdat.net Esdat Environmental D
Page 321: www.esdat.net Esdat Environmental D
show all

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

Create successful ePaper yourself

Delete template?

Save as template?