Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Styrene<br />
TDI inhal<br />
Organisation<br />
Description Response Reference Web link<br />
<strong>Health</strong> Protection Agency (HPA)<br />
Long term human exposure to Styrene HPA Compendium of Chemical Hazards, Styrene. JC Wakefield, HPA 2008<br />
reported to cause subtle changes in hearing,<br />
balance, colour vision, psychological<br />
per<strong>for</strong>mance and asthma<br />
http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1202115635291<br />
<strong>Health</strong> Protection Agency (HPA)<br />
<strong>Health</strong> Protection Agency (HPA)<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and<br />
the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
Minor effects on the central nervous system<br />
observed in humans exposed to 107mg/m3 of<br />
styrene <strong>for</strong> a period of several years. 107mg/m3<br />
can be converted to 26mg/m3 to account <strong>for</strong><br />
continuous exposure<br />
Liver Weight, Serum Enzyme Levels and<br />
neurological effects<br />
RIVM Report 711701 025. Re-evaluation of human toxicological maximum<br />
permissible risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M. Hesse,<br />
M.E. van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker March 2001<br />
(Primary Reference given as: Toxicological Profile <strong>for</strong> Styrene, ATSDR 1992)<br />
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf<br />
<strong>Health</strong> Canada Toxicological Values<br />
Offspring exposed to 60 to 293 ppm <strong>for</strong> 6 hrs/day<br />
during days 7 to 21 days of gestation<br />
Reduced weight of offspring Primary Reference: Kishi et al. 1992a, 1992b http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-<br />
lsp1/stryene/styrene_3-eng.php<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATSDR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
Toxicology Data Network (Toxnet)<br />
Analysis of data recorded from several studies Choice Reaction Time and Colour<br />
including Kishi et al. (2001) and Mutti et al. (1984) Recognition<br />
Styrene occupational exposure was assessed by<br />
the authors to correspond to air concentrations<br />
ranging from 10-300 ppm as a mean daily<br />
exposure.<br />
ATSDR, Toxicological Profile <strong>for</strong> Styrene. Draft <strong>for</strong> Public Comment. September<br />
2007 Primary Study Reference: Benignus et al. 2005, <strong>Human</strong><br />
neurobehavioral effects of long-term exposure to Styrene: a Meta-analysis.<br />
Environmental <strong>Health</strong> Perspect 113: 532-538<br />
http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_mrls_december_2008.pdf<br />
neuropsychological Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini. 1984. http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~crTanp:1<br />
Exposure-effect and exposure-response relationships between occupational<br />
exposure to styrene and neuropsychological functions. Am. J. Ind. Med. 5: 275-<br />
286.<br />
as IRIS as IRIS as IRIS as IRIS<br />
Page4 of 4<br />
EIC Pro<strong>for</strong>ma styrene.xls28/08/2009]
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