Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Styrene
TDI oral
Organisation
Description Target organ/Critical Effect Reference Web link
Health Protection Agency (HPA)
Toxic by inhalation, ingestion and skin contact.
Possible human carcinogen and cause of CNS
depression.
Irritation to any tissues contacted. Limited
evidence from animal studies that styrene
will cause adverse effects on reproduction.
HPA Compendium of Chemical Hazards, Styrene. JC Wakefield, HPA 2008
http://www.hpa.org.uk/web/HPAwebFile/HPAweb_C/1202115635291
Rats - increased liver and kidney weights,
growth depression
Health and Safety Executive (HSE)
HSE 2
CNS depression, skin, eye and respiratory
tract irritation, repeated dose toxicity
CNS depression, skin, eye and respiratory
tract irritation, repeated dose toxicity
Scientific Committee on Food (SCF) pre 2002
See WHO guidelines for DW See WHO guidelines for DW WHO (1993). Guidelines for drinking water guidelines, 2 nd edition, vol. 1. Health
criteria and other supporting information. World Health Organization, Geneva.
http://ec.europa.eu/food/fs/sc/scf/out24_en.html
International Programme on Chemical Safety
(IPCS)
2 year oral study rats received 0, 125mg/l and
250mg/l in drinking water. At 250mg/l females
showed lower terminal body weight than lower
dose groups. 125mg/l identified as an NOAEL
equating to 7.7mg/kg (males) and 12mg/kg
(females)
Reduced body weight
Styrene in Drinking Water. Background Document for the development of WHO http://www.who.int/water_sanitation_health/dwq/chemicals/styrene.pdf
Guidelines for Drinking-water Quality. World Health Organisation 2003
Primary (Study) Reference given as: Chemical Manufacturers Association (1980)
Toxicological study on styrene incorporated in drinking water of rats for two
years in conjunction with three generation reproduction study. Litton Bionetic
IPCS INCHEM
As above As Above Primary Reference given as: Chemical Manufacturers Association (1980) http://www.inchem.org/documents/jecfa/jecmono/v19je15.htm
Toxicological study on styrene incorporated in drinking water of rats for two
years in conjunction with three generation reproduction study. Litton Bionetics
WHO Guidelines for drinking water Quality
2 year oral study rats received 0, 125mg/l and
250mg/l in drinking water. At 250mg/l females
showed lower terminal body weight than lower
dose groups. 125mg/l identified as an NOAEL
equating to 7.7mg/kg (males) and 12mg/kg
(females)
Reduced body weight
Guidelines for Drinking-water Quality. First Addendum to the Third Edition. http://www.who.int/water_sanitation_health/dwq/gdwq0506.pdf
Volume 1, Recommendations. World Health Organisation 2006 Principal
Reference: Styrene in Drinking Water. Background Document for the
development of WHO Guidelines for Drinking-water Quality. World Health
Organisation 2003
Dutch National Institute for Public Health and
the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
2 year oral study rats received 0, 125mg/l and
250mg/l in drinking water. At 250mg/l females
showed lower terminal body weight than lower
dose groups. 125mg/l identified as an NOAEL for
females. Males showed no effects at 250mg/l
(NOAEL). i.e.. This is the same study but different
interpretation of the results from the WHO
approach above
Reduced body weight in females
RIVM Report 711701 025. Re-evaluation of human toxicological maximum
permissible risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M. Hesse,
M.E. van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker March 2001
(Primary Reference given as Van Apeldorn et al. 1986)
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf
Health Canada Toxicological Values
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
USEPA Acute Guideline Levels (AEGLs)
USEPA Health Advisors
Dose groups of 125mg/l and 250 mg/l in drinking Reproductive effects in three generation rat Primary (Study) Reference: Beliles et al. 1985
water. Over three generations. 125mg/l identified study
as NOAEL. 250mg/l as LOAEL
http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-
lsp1/stryene/styrene_3-eng.php
http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_mrls_december_2008.pdf
/
USEPA Integrated Risk Information System
(IRIS)
Toxicology Data Network (Toxnet)
Four beagle dogs/sex were gavaged with doses of
0, 200, 400, or 600 mg styrene/kg bw/day in
peanut oil for 560 days. No adverse effects were
observed for dogs administered styrene at 200
mg/kg-day.
Red blood cell and liver effects
Quast, J.F., C.G. Humiston, R.Y. Kalnins, et al. 1979. Results of a toxicity study of
monomeric styrene administered to beagle dogs by oral intubation for 19
months. Toxicology Research Laboratory, Health and Environmental Sciences,
DOW Chemical Co., Midland, MI. Final Report.
as above as above as above as above
http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~wxAHsQ:1
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EIC Proforma styrene.xls28/08/2009]