Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Propylbenzene CAS Number: 103-65-1 Assessor A: David Gallagher (ERM) Assessor B: Simon Clennell-Jones
(WSP)
Final review:
Panel/SF
Date 20/05/2009 Date 01/06/2009 Date 28/08/2009
Oral
Dermal
Inhalation
Combine Oral and
Inhalation TDIs
Justification
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
Yes Yes No
No No No
No No Yes
No No No
Yes
Carcinogenicity unclassified by IARC or USEPA.
Toxicological data suggests it is unlikely to be a
carcinogen. Insufficient data with sufficient detail on
derivation to derive TDI.
Carcinogenicity unclassified by IARC or USEPA.
Toxicological data suggests it is unlikely to be a
carcinogen. Insufficient data with sufficient detail on
derivation to derive TDI.
TDI oral
Recommended TDIoral Units
100 ug.kg-1.d-1
Justification
Ethylbenzene tox from EA 2009 TOX report. USEPA PPRTV recommend ethylbenzene tox for developing a "screening value" for Propylbenzene.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-1.d-1 Confidence rating Basis Value Units UF UF description Study type Description
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
http://rais.ornl.gov/tox/unauthorized.shtml Feb-09 NA RFD PPRTV No chronic or sub
chronic RfDs have been
developed due to a lack
of data. However,
ethylbenzene
toxicological data is
recommended as a
surrogate for
propylbenzene for
developing a "screening
value". Ethylbenzene is
considered to have
similar patterns of
absoroptions,
metabolism and
neurological effects and
considered to be more
toxic than n-
propylbenzene.
Texas Commission on Environmental
Quality. Texas Risk Reduction Program
Protective Concentration Levels
http://www.tceq.state.tx.us/remediation/trr
p/trrppcls.html
26/03/2009 19/05/2009 Threshold 4.00E-02 mg/kg/bw/day 40 unknown unknown RfD sourced from National Centre for
Environmental Assessment (NCEA)
TDI inhal
Recommended
TDIinhal
Units
220 ug.kg-1.d-1
Justification
Ethylbenzene tox from EA 2009 TOX report. USEPA PPRTV recommend ethylbenzene tox for developing a "screening value" for Propylbenzene.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-1.d-1 Confidence rating Basis Value Units UF UF description Study type Description
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
http://rais.ornl.gov/tox/unauthorized.shtml Feb-09 NA RFC PPRTV No chronic or sub
chronic RfDs have been
developed due to a lack
of data. However,
ethylbenzene
toxicological data is
recommended as a
surrogate for
propylbenzene fro
developing a "screening
value". Ethylbenzene is
considered to have
similar patterns of
absoroptions,
metabolism and
neurological effects and
considered to be more
toxic than n-
propylbenzene.
Texas Commission on Environmental
Quality. Texas Risk Reduction Program
Protective Concentration Levels
http://www.tceq.state.tx.us/remediation/trr
p/trrppcls.html
26/03/2009 19/05/2009 Threshold 4.00E-01 mg/m 3 114 unknown unknown RfC sourced from unidentified source
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EIC proforma propylbenzene-n.xls28/08/2009