Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Methyl tert-butyl ether<br />
TDI inhal<br />
Organisation<br />
Description Response Reference Web link<br />
Committee on the Medical<br />
Effects of Air Pollutants<br />
(COMEAP)<br />
European Chemicals Bureau<br />
(ECB)<br />
Rat study Motor activity affected <strong>Health</strong> Effects Institute: The Potential<br />
<strong>Health</strong> Effects of Oxygenates added to Gasoline (1996).<br />
An inhalation NOAEC of 800 ppm has been<br />
used based on a) inhalation exposure in a 13<br />
week rat study<br />
b) 2 year rat study<br />
a) mild liver effects at 4000 ppm<br />
b) mild liver effects at 3000 ppm<br />
a) Lington AW, Dodd DE, Ridlon SA, Douglas JF, Kneiss JJ & Andrews LS<br />
(1997). Evaluation of 13-week inhalation<br />
toxicity study on methyl t-butyl ether (MTBE) in Fischer 344 rats. Journal<br />
of Applied Toxicology, 17.<br />
b) Bird MG, Burleigh-Flayer HD, Chun JS, Dou<br />
http://www.advisorybodies.doh.gov.uk/comeap/pdfs/comeap-99-00.pdf<br />
http://ecb.jrc.ec.europa.eu/Documents/Existing-<br />
Chemicals/RISK_ASSESSMENT/REPORT/mtbereport313.pdf<br />
IPCS Environmental <strong>Health</strong><br />
<strong>Criteria</strong> (EHC) Monographs<br />
An oncogenicity study was also carried out on Effects on the liver<br />
CD-1 mice exposed to MTBE (99% pure) vapour<br />
in inhalation chambers (Burleigh-Flayer et al.,<br />
1992; Bird et al., 1997). Groups of 50 male and<br />
50 female mice were exposed to target<br />
concentrations of 0, 1430, 10 7<br />
Burleigh-Flayer HD, Chun JS, & Kintigh WJ (1992) Methyl tertiary butyl<br />
ether: vapor inhalation oncogenicity study in CD-1 mice (Laboratory<br />
project ID 91N0013A). Export, Pennsylvania, Bushy Run Research Center,<br />
1068 pp (Report to the Methyl Tertiary Butyl<br />
http://inchem.org/documents/ehc/ehc/ehc206.htm#SubSectionNumber:7<br />
.4.2<br />
WHO Guidelines <strong>for</strong> drinking<br />
water Quality<br />
Dutch National Institute <strong>for</strong><br />
Public <strong>Health</strong> and the<br />
Environment (RIVM)<br />
Maximum Permissible <strong>Risk</strong><br />
(MPR) levels<br />
US Agency <strong>for</strong> Toxic<br />
Substances and Disease<br />
Registry (ATSDR) Toxicological<br />
Profiles and Minimal <strong>Risk</strong><br />
levels<br />
USEPA Integrated <strong>Risk</strong><br />
In<strong>for</strong>mation System (IRIS)<br />
Daily exposure of male and female rats to<br />
MTBE at 2900 mg.m-3 <strong>for</strong> 13 weeks<br />
28 day inhalation study of rat. Exposure of 6<br />
hrs/day, 5 days/week<br />
24 month inhalation rat study. Exposure of 6<br />
hr/day, 5 d/week.<br />
24 month inhalation rat study. Exposure of 6<br />
hr/day, 5 d/week.<br />
Absolute but not relative decrease in<br />
brain weight<br />
Miller MJ et al. (1997) Pharmacokinetics and disposition of methyl t-butyl<br />
ether in Fischer-344 rats. Journal of Applied Toxicology, 17(Suppl. 1):<br />
S3–S12.<br />
Increased liver and kidney weight TCA from ECB (2002) based on Chun et al. 1993.<br />
ECB (2002). European Union <strong>Risk</strong> <strong>Assessment</strong> Report t-butyl methyl ether.<br />
European Chemicals Bureau, 3rd Priority list, volume 19; Office <strong>for</strong> Official<br />
Publications of the EC, Luxembourg.<br />
Increased liver and kidney weight<br />
Increased absolute and relative liver and<br />
kidney weights and increased severity of<br />
spontaneous renal lesions (females),<br />
increased prostration (females), and<br />
swollen periocular tissue (males and<br />
females)<br />
http://www.who.int/water_sanitation_health/dwq/chemicals/MTBE2006<br />
05.pdf<br />
http://www.rivm.nl/bibliotheek/rapporten/711701039.pdf<br />
RFC from IRIS 1996 based on Chun JS, Burleigh-Flayer HD, Kintigh WJ. http://www.atsdr.cdc.gov/toxprofiles/tp91.pdf<br />
1992. Methyl tertiary butyl ether: Vapor inhalation<br />
oncogenicity study in Fischer 344 rats. Bushy Run Research Center, Export,<br />
PA. Project No. 91N0013B.<br />
Chun, J.S., H.D. Burleigh-Flayer, and W.J. Kintigh. 1992. Methyl tertiary<br />
butyl ether: vapor inhalation oncogenicity study in Fischer 344 rats<br />
(unpublished material). Prepared <strong>for</strong> the MTBE Committee by Bushy Run<br />
Research Center, Union Carbide Chemicals.<br />
http://www.epa.gov/ncea/iris/subst/0545.htm<br />
ID oral<br />
Organisation<br />
European Chemicals Bureau<br />
(ECB)<br />
International Agency <strong>for</strong><br />
Research on Cancer (IARC)<br />
Description Response Reference Web link<br />
Tumours have been reported in rats at doses <br />
250 mg.kg-1<br />
IPCS Environmental <strong>Health</strong><br />
<strong>Criteria</strong> (EHC) Monographs<br />
Dutch National Institute <strong>for</strong><br />
Public <strong>Health</strong> and the<br />
Environment (RIVM)<br />
Maximum Permissible <strong>Risk</strong><br />
(MPR) levels<br />
4 of 6 C:\Firth Consultants\projects\eic\EIC GAC\3rd phase\Final Pro<strong>for</strong>mas\EIC Pro<strong>for</strong>ma MTBE.xls26/08/2009
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