Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Methyl tert-butyl ether<br />
TDI oral<br />
Organisation<br />
Description Target organ/Critical Effect Reference Web link<br />
European Chemicals Bureau<br />
(ECB)<br />
Oral NOAEL of 300 mg/kg based on<br />
a) 90 day study of Sprague-Dawley rats<br />
b) Male rat study<br />
a) Elevated AST with weight increase at<br />
900 mg/kg<br />
b) Slight morphological liver<br />
abnormalities at 200 mg/kg<br />
a) Robinson M, Bruner RH & Olson GR (1990). Fourteen- and ninety-day<br />
oral toxicity studies of methyl tertiary-butyl<br />
ether in Sprague-Dawley rats. Journal of the American College of<br />
Toxicology, 9, 525-540.<br />
b) Zhou W & Ye S (1999). Subchronic Oral Methyl Ter<br />
http://ecb.jrc.ec.europa.eu/Documents/Existing-<br />
Chemicals/RISK_ASSESSMENT/REPORT/mtbereport313.pdf<br />
IPCS Environmental <strong>Health</strong><br />
<strong>Criteria</strong> (EHC) Monographs<br />
WHO Guidelines <strong>for</strong> drinking<br />
water Quality<br />
Dutch National Institute <strong>for</strong><br />
Public <strong>Health</strong> and the<br />
Environment (RIVM)<br />
Maximum Permissible <strong>Risk</strong><br />
(MPR) levels<br />
In a 28-day oral study, Sprague-Dawley rats<br />
(10/sex/group) were<br />
administered 0, 90, 440 or 1750 mg<br />
undiluted MTBE (purity not<br />
specified)/kg bw daily by gavage <strong>for</strong> a total<br />
of 20 h (IITRI, 1992).<br />
In a 90 day study groups of 10 male and female<br />
rats were administered 0, 100,300, 900 or 1200<br />
mg.kg bw-1. d-1 of MTBE in corn oil<br />
a) 90 day oral by gavage study in rats<br />
b) 90 day oral by gavage study in rats<br />
Increased kidney weights IITRI (1992) 28-day oral (gavage) toxicity of methyl tert-butyl ether<br />
(MTBE) in rats (Project No. L08100). Chicago, Illinois, Illinois Institute of<br />
Technology Research, 48 pp.<br />
Increase in relative kidney weight<br />
a) Kidney and liver toxicity<br />
b) Increased liver and kidney weight<br />
Robinson M, Bruner RH, Olson GR (1990) Fourteen- and ninety-day oral<br />
toxicity studies of methyl<br />
tertiary-butyl ether in Sprague-Dawley rats. Journal of the American<br />
College of Toxicology, 9: 525–<br />
540.<br />
TDI within ECB (2002) based on a) and b).<br />
ECB (2002). European Union <strong>Risk</strong> <strong>Assessment</strong> Report t-butyl methyl ether.<br />
European Chemicals Bureau, 3rd Priority list, volume 19; Office <strong>for</strong> Official<br />
Publications of the EC, Luxembourg.<br />
a) Robinson M, Bruner RH, Ol<br />
http://inchem.org/documents/ehc/ehc/ehc206.htm#SubSectionNumber:7<br />
.4.1<br />
http://www.who.int/water_sanitation_health/dwq/chemicals/MTBE2006<br />
05.pdf<br />
http://www.rivm.nl/bibliotheek/rapporten/711701039.pdf<br />
<strong>Health</strong> Canada Toxicological<br />
Values<br />
<strong>Health</strong> Canada has determined that there exist<br />
too many uncertainties and limitations in the<br />
MTBE database to have confidence in a<br />
quantitative risk assessment <strong>for</strong> human health.<br />
Guidelines <strong>for</strong> Canadian Drinking Water Quality: Guideline Technical<br />
Document. Methyl Tertiary-Butyl Ether (MTBE). <strong>Health</strong> Canada, Ottawa,<br />
Ontario, July 2006<br />
http://www.hc-sc.gc.ca/ewh-semt/alt_<strong>for</strong>mats/hecs-sesc/pdf/pubs/watereau/mtbe/mtbe-eng.pdf<br />
US Agency <strong>for</strong> Toxic<br />
Substances and Disease<br />
Registry (ATSDR) Toxicological<br />
Profiles and Minimal <strong>Risk</strong><br />
levels<br />
USEPA <strong>Health</strong> Advisors<br />
Entrez PubMed<br />
90 day study Hepatic effects Robinson M, Bruner RH, Olson GR (1990) Fourteen- and ninety-day oral<br />
toxicity studies of methyl<br />
tertiary-butyl ether in Sprague-Dawley rats. Journal of the American<br />
College of Toxicology, 9: 525–<br />
540.<br />
90 day oral exposure study in rats Kidney effects Robinson M, Bruner RH, Olson GR (1990) Fourteen- and ninety-day oral<br />
toxicity studies of methyl<br />
tertiary-butyl ether in Sprague-Dawley rats. Journal of the American<br />
College of Toxicology, 9: 525–<br />
540.<br />
MTBE administered to rats at doses of<br />
0,400,800 and 1600 mg. Kg bw-1.d-1.<br />
Relative change in heart, liver, kidney,<br />
testes, thymus and prostate weight<br />
Effects of subchronic methyl tert-butyl ether ether exposure on male<br />
Sprague-Dawley rats. Dong-Mei L, Yi G, Chun-Tao Y, Yu-Feng H, Xiao-Dong<br />
H. Toxicol Ind <strong>Health</strong>. 2009 Feb;25(1):15-23.<br />
http://www.atsdr.cdc.gov/toxprofiles/tp91.pdf<br />
http://www.epa.gov/waterscience/criteria/drinking/mtbe.pdf<br />
http://www.ncbi.nlm.nih.gov/pubmed/19318501ordinalpos=2&itool=Ent<br />
rezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultRepo<br />
rtPanel.Pubmed_RVDocSum<br />
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