Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Isopropylbenzene CAS Number: 98-82-8 Assessor A: Simon Clennell-Jones (WSP) Assessor B: Simon Tempest (ERM) Final review: Panel/SF TDI inhal Recommended TDIinhal Units Date 19/05/2009 Date 20/05/2009 Date 28/08/2009 Justification 114.3 μg/kg.bw/day CICAD (NOAEL/LOAEL), IRIS, USEPA Region 9, RAIS, Texas provide consistent value. CICAD NOAEL not considered as NOAEL has been demonstrated within the same source at concentrations greater than this. USEPA Acute criteria not considered appropriate for assessing chronic risks. Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- 1.d-1 Confidence rating Basis Value Units UF UF description Study type European Chemicals Bureau (ECB) http://ecb.jrc.it/ unknown 18/05/2009 NOAEL 490 mg/m3 140000 NOAEL 490 mg/m3 0 Rats are reported to be one of the most sensitive animal to cumene. Toxicokinetics not reportedly qualitatively different between humans and animals. rats IPCS concise International Chemical Assessment Documents (CICADs) http://inchem.org/pages/cicads.html unknown 18/05/2009 Guidance Value 0.4 mg/m3 114.3 NOAEL but also regarded as a potential LOAEL (adjusted for continuous exposure) 436 mg/m3 1000 10 - interindividual 10 - sub chronic to chronic 10 -0.5 - interspecies 10 -0.5 - database deficiencies (lack of full scale multi-generation reproductive study) rats IPCS concise International Chemical Assessment Documents (CICADs) http://inchem.org/pages/cicads.html unknown 18/05/2009 Guidance Value 0.09 mg/m3 25.7 NOAEL (adjusted for continuous exposure) 88 mg/m3 1000 10 - interindividual 10 - sub chronic to chronic 10 -0.5 - interspecies 10 -0.5 - database deficiencies (lack of full scale multi-generation reproductive study) rats USEPA Acute Guideline Levels (AEGLs) http://epa.gov/oppt/aegl/pubs/chemlist.htm 13/02/2009 19/05/2009 Acute Exposure Guideline Value - AEGL 1 (non disabling 8 hour duration) 250 mg/m3 71428 Value painful to eyes 300 ppm 6 2 - cause effect within scope of AEGL 1 i.e. mild eye and respiratory irritation. 3- intraspecies variability Human & rat data USEPA Health Advisors USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/waterscience/criteria/dr inking 27/04/2009 19/05/2009 http://epa.gov/iris/ 01/08/1997 19/05/2009 RfC 0.4 mg/m3 114.3 medium NOAEL 435 mg/m3 1000 10 - sub chronic to chronic 10 - intraspecies variation 3 - interspecies variation 3 - database deficiencies (lack of reproductive studies) Rat USEPA Region 9 Preliminary Remediation Goals http://www.epa.gov/region09/superfund/pr g/ 12/05/2009 19/05/2009 RfC 0.4 mg/m3 114.3 unknown unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels http://www.tceq.state.tx.us/remediation/trr p/trrppcls.html 26/03/2009 19/05/2009 RfC 0.4 mg/m3 114.3 unknown unknown The Risk Assessment Information System (RAIS) http://rais.ornl.gov/ 17/08/2005 19/05/2009 RfC 0.4 mg/m3 114.3 medium NOAEL/LOAEL 1000 unknown Rat Page 3 of 4 EIC proforma isopropylbenzene.xls28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Isopropylbenzene TDI inhal Organisation Description Response Reference Web link European Chemicals Bureau (ECB) 90 day exposure study of rats exposed to 500 and 1200ppm cumene Depression of CNS and increases in liver, kidney and dermal gland weight. European Commission, Joint Research Centre, August 1999. Cumene, http://ecb.jrc.ec.europa.eu/documents/Existing- Summary Risk Assessment Report. (Preface of report states "summary report Chemicals/RISK_ASSESSMENT/SUMMARY/cumenesum007.pdf should preferably not be used for citation purposes") IPCS concise International Chemical Assessment Documents (CICADs) 3 month sub chronic inhalation study by Cushman et al 1995. increased kidney and adrenal weights and central nervous system, haematological, and clinical biochemical alterations, which were observed in rats. IPCS INCHEM, 1999. Concise International Chemical Assessment Document 18. Cumene. http://inchem.org/documents/cicads/cicads/cicad18.htm IPCS concise International Chemical Assessment Documents (CICADs) 3 month sub chronic inhalation study by Cushman et al 1995. increased kidney and adrenal weights and central nervous system, haematological, and clinical biochemical alterations, which were observed in rats. IPCS INCHEM, 1999. Concise International Chemical Assessment Document 18. Cumene. http://inchem.org/documents/cicads/cicads/cicad18.htm USEPA Acute Guideline Levels (AEGLs) volunteers willingly tolerated exposure to 49- 146 ppm cumene for an 8-hour period with two 30-minute breaks & several rat studies (a single or multiple exposures for 6 hours to 100 ppm caused no toxic effects) Mild eye and respiratory irritation in humans USEPA. Acute Exposure Guidelines (AEGLs) for Cumene (CAS 98-82-8). Interim 1- 8/2007. http://epa.gov/oppt/aegl/pubs/cumene_tsd_interimversion1_8_28_07.pdf USEPA Health Advisors USEPA Integrated Risk Information System (IRIS) 13 week inhalation study of rats by Cushman et al 1995. Increased kidney weights in female rats and adrenal weights in male and female rats USEPA. Integrated Risk Information System. Cumene (CAS 98-82-8). Accessed 19th May 2009. http://cfpub.epa.gov/ncea/iris/index.cfmfuseaction=iris.showQuickView&s ubstance_nmbr=0306 USEPA Region 9 Preliminary Remediation Goals RfC sourced from IRIS unknown USEPA Region 9. Preliminary Remediation Goals, Screening Levels for Contaminants. Accessed 19th May 2009. http://www.epa.gov/region09/superfund/prg/pdf/indsoil_sl_table_run_APR IL2009.pdf Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels RfC sourced from IRIS unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels. Accessed 19th May 2009 http://www.tceq.state.tx.us/remediation/trrp/trrppcls.html The Risk Assessment Information System (RAIS) study by Cushman et al 1995 referenced by IRIS. Kidney / Increased kidney weights in female rats and adrenal weights in male and female rats Risk Assessment Information System (RAIS). Accessed 19th May 2009. http://rais.ornl.gov/cgi-bin/tox/TOX_select Page 4 of 4 EIC proforma isopropylbenzene.xls28/08/2009
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