Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Isopropylbenzene CAS Number: 98-82-8 Assessor A: Simon Clennell-Jones
(WSP)
Assessor B:
Simon Tempest
(ERM)
Final review: Panel/SF
TDI inhal Recommended TDIinhal Units
Date 19/05/2009 Date 20/05/2009 Date 28/08/2009
Justification
114.3 μg/kg.bw/day
CICAD (NOAEL/LOAEL), IRIS, USEPA Region 9, RAIS, Texas provide consistent value. CICAD NOAEL not considered as NOAEL has been demonstrated within
the same source at concentrations greater than this. USEPA Acute criteria not considered appropriate for assessing chronic risks.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Confidence
rating
Basis Value Units UF UF description Study type
European Chemicals Bureau (ECB) http://ecb.jrc.it/ unknown 18/05/2009 NOAEL 490 mg/m3 140000 NOAEL 490 mg/m3 0 Rats are reported to be one of the
most sensitive animal to cumene.
Toxicokinetics not reportedly
qualitatively different between
humans and animals.
rats
IPCS concise International Chemical
Assessment Documents (CICADs)
http://inchem.org/pages/cicads.html unknown 18/05/2009 Guidance Value 0.4 mg/m3 114.3 NOAEL but also
regarded as a
potential LOAEL
(adjusted for
continuous
exposure)
436 mg/m3 1000 10 - interindividual
10 - sub chronic to chronic
10 -0.5 - interspecies
10 -0.5 - database deficiencies (lack of
full scale multi-generation
reproductive study)
rats
IPCS concise International Chemical
Assessment Documents (CICADs)
http://inchem.org/pages/cicads.html unknown 18/05/2009 Guidance Value 0.09 mg/m3 25.7 NOAEL (adjusted
for continuous
exposure)
88 mg/m3 1000 10 - interindividual
10 - sub chronic to chronic
10 -0.5 - interspecies
10 -0.5 - database deficiencies (lack of
full scale multi-generation
reproductive study)
rats
USEPA Acute Guideline Levels (AEGLs) http://epa.gov/oppt/aegl/pubs/chemlist.htm 13/02/2009 19/05/2009 Acute Exposure
Guideline Value -
AEGL 1 (non disabling
8 hour duration)
250 mg/m3 71428 Value painful to
eyes
300 ppm 6 2 - cause effect within scope of AEGL 1
i.e. mild eye and respiratory irritation.
3- intraspecies variability
Human & rat data
USEPA Health Advisors
USEPA Integrated Risk Information System
(IRIS)
http://www.epa.gov/waterscience/criteria/dr
inking
27/04/2009 19/05/2009
http://epa.gov/iris/ 01/08/1997 19/05/2009 RfC 0.4 mg/m3 114.3 medium NOAEL 435 mg/m3 1000 10 - sub chronic to chronic
10 - intraspecies variation
3 - interspecies variation
3 - database deficiencies (lack of
reproductive studies)
Rat
USEPA Region 9 Preliminary Remediation
Goals
http://www.epa.gov/region09/superfund/pr
g/
12/05/2009 19/05/2009 RfC 0.4 mg/m3 114.3 unknown unknown
Texas Commission on Environmental
Quality. Texas Risk Reduction Program
Protective Concentration Levels
http://www.tceq.state.tx.us/remediation/trr
p/trrppcls.html
26/03/2009 19/05/2009 RfC 0.4 mg/m3 114.3 unknown unknown
The Risk Assessment Information System
(RAIS)
http://rais.ornl.gov/ 17/08/2005 19/05/2009 RfC 0.4 mg/m3 114.3 medium NOAEL/LOAEL 1000 unknown Rat
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EIC proforma isopropylbenzene.xls28/08/2009