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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Isopropylbenzene CAS Number: 98-82-8 Assessor A: Simon Clennell-Jones (WSP) Assessor B: Simon Tempest (ERM) Final review: Panel/SF Date 19/05/2009 Date 20/05/2009 Date 28/08/2009 Oral Dermal Inhalation Combine Oral and Inhalation TDIs Justification Apply TDIoral to exposure routes Apply IDoral to exposure routes Yes Yes No No No No Unclassified by IARC, USEPA Group D not classifiable as to human carcinogenicity - TDIoral applied to oral and dermal routes Yes Apply TDIinh to exposure routes Apply IDinh to exposure routes No No Yes No No No Unclassified by IARC, USEPA Group D not classifiable as to human carcinogenicity- TDIinh applied to inhalation routes TDI oral Recommended TDIoral Units 100 μg/kg.bw/day Justification CICADs, IRIS, USEPA Region 9, RAIS, Texas provide consistent value Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- 1.d-1 Confidence rating Basis Value Units UF UF description Study type European Chemicals Bureau (ECB) http://ecb.jrc.it/ unknown 18/05/2009 NOAEL 154 mg/kg/bw/day 154,000 NOAEL 154 mg/kg/bw/day 0 Rats are reported to be one of the most sensitive animal to cumene. Toxicokinetics not reportedly qualitatively different between humans and animals. oral gavage study of rats IPCS concise International Chemical Assessment Documents (CICADs) http://inchem.org/pages/cicads.html unknown 18/05/2009 Guidance Value 0.1 mg/kg/bw/day 100 NOAEL 110 mg/kg/bw/day 1000 10 - interindividual 10 - interspecies 10 -0.5 - sub chronic to chronic 10 -0.5 - lack of full scale multigeneration reproductive study oral (gavage) study of rats USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 01/08/1997 19/05/2009 RfD 0.1 mg/kg/bw/day 100 Low NOAEL 110 mg/kg/bw/day 1000 10 - interspecies variation 10 - intraspecies variation 3 - sub chronic to chronic 3 - database deficiencies (lack of reproductive information) Rat USEPA Region 9 Preliminary Remediation Goals http://www.epa.gov/region09/superfund/pr g/ 12/05/2009 19/05/2009 RfD 0.1 mg/kg/bw/day 100 unknown unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels The Risk Assessment Information System (RAIS) http://www.tceq.state.tx.us/remediation/trr p/trrppcls.html 26/03/2009 19/05/2009 RfD 0.1 mg/kg/bw/day 100 unknown unknown http://rais.ornl.gov/ 17/08/2005 19/05/2009 RfD 0.1 mg/kg/bw/day 100 Low NOAEL/LOAEL 1000 unknown Rat Page 1 of 4 EIC proforma isopropylbenzene.xls28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Isopropylbenzene TDI oral Organisation Description Target organ/Critical Effect Reference Web link European Chemicals Bureau (ECB) 6 month study of rats for cumene administered in olive oil by gavage. Depression of CNS and increases in liver, kidney and dermal gland weight. European Commission, Joint Research Centre, August 1999. Cumene, http://ecb.jrc.ec.europa.eu/documents/Existing- Summary Risk Assessment Report. (Preface of report states "summary report Chemicals/RISK_ASSESSMENT/SUMMARY/cumenesum007.pdf should preferably not be used for citation purposes") IPCS concise International Chemical Assessment Documents (CICADs) increased average kidney weight in rats following sub-chronic (139/194 days) oral exposure in study by Wolf et al 1956. Kidneys. Increase in organ weight (most notably the kidney). IPCS INCHEM, 1999. Concise International Chemical Assessment Document 18. Cumene. http://inchem.org/documents/cicads/cicads/cicad18.htm USEPA Integrated Risk Information System (IRIS) 194 day rat oral gavage study by Wolf et al 1956. Increased average kidney weight in female rats USEPA. Integrated Risk Information System. Cumene (CAS 98-82-8). Accessed 19th May 2009. http://cfpub.epa.gov/ncea/iris/index.cfmfuseaction=iris.showQuickView&s ubstance_nmbr=0306 USEPA Region 9 Preliminary Remediation Goals RfD sourced from IRIS unknown USEPA Region 9. Preliminary Remediation Goals, Screening Levels for Contaminants. Accessed 19th May 2009. http://www.epa.gov/region09/superfund/prg/pdf/indsoil_sl_table_run_APR IL2009.pdf Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels The Risk Assessment Information System (RAIS) RfD sourced from IRIS unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels. Accessed 19th May 2009. study by Wolf et al 1956 referenced by IRIS. Kidney / Increased average kidney weight in female rats Risk Assessment Information System (RAIS). Accessed 19th May 2009. http://www.tceq.state.tx.us/remediation/trrp/trrppcls.html http://rais.ornl.gov/cgi-bin/tox/TOX_select Page 2 of 4 EIC proforma isopropylbenzene.xls28/08/2009
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