Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Isopropylbenzene CAS Number: 98-82-8 Assessor A: Simon Clennell-Jones
(WSP)
Assessor B:
Simon Tempest
(ERM)
Final review: Panel/SF
Date 19/05/2009 Date 20/05/2009 Date 28/08/2009
Oral
Dermal
Inhalation
Combine Oral
and Inhalation
TDIs
Justification
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Yes Yes No
No No No
Unclassified by IARC, USEPA Group D not
classifiable as to human carcinogenicity - TDIoral
applied to oral and dermal routes
Yes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
No No Yes
No No No
Unclassified by IARC, USEPA Group D not
classifiable as to human carcinogenicity- TDIinh
applied to inhalation routes
TDI oral Recommended TDIoral Units
100 μg/kg.bw/day
Justification
CICADs, IRIS, USEPA Region 9, RAIS, Texas provide consistent value
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Confidence
rating
Basis Value Units UF UF description Study type
European Chemicals Bureau (ECB) http://ecb.jrc.it/ unknown 18/05/2009 NOAEL 154 mg/kg/bw/day 154,000 NOAEL 154 mg/kg/bw/day 0 Rats are reported to be one of the
most sensitive animal to cumene.
Toxicokinetics not reportedly
qualitatively different between
humans and animals.
oral gavage study
of rats
IPCS concise International Chemical
Assessment Documents (CICADs)
http://inchem.org/pages/cicads.html unknown 18/05/2009 Guidance Value 0.1 mg/kg/bw/day 100 NOAEL 110 mg/kg/bw/day 1000 10 - interindividual
10 - interspecies
10 -0.5 - sub chronic to chronic
10 -0.5 - lack of full scale multigeneration
reproductive study
oral (gavage)
study of rats
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 01/08/1997 19/05/2009 RfD 0.1 mg/kg/bw/day 100 Low NOAEL 110 mg/kg/bw/day 1000 10 - interspecies variation
10 - intraspecies variation
3 - sub chronic to chronic
3 - database deficiencies (lack of
reproductive information)
Rat
USEPA Region 9 Preliminary Remediation
Goals
http://www.epa.gov/region09/superfund/pr
g/
12/05/2009 19/05/2009 RfD 0.1 mg/kg/bw/day 100 unknown unknown
Texas Commission on Environmental
Quality. Texas Risk Reduction Program
Protective Concentration Levels
The Risk Assessment Information System
(RAIS)
http://www.tceq.state.tx.us/remediation/trr
p/trrppcls.html
26/03/2009 19/05/2009 RfD 0.1 mg/kg/bw/day 100 unknown unknown
http://rais.ornl.gov/ 17/08/2005 19/05/2009 RfD 0.1 mg/kg/bw/day 100 Low NOAEL/LOAEL 1000 unknown Rat
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EIC proforma isopropylbenzene.xls28/08/2009