Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Hexachloroethane CAS Number: 67-72-1 Assessor A: A Fellows - Ecologia Assessor B: J Brown - DTS RaeFinal review: Panel/SF Date 15.04.09 Date 16.04.09 Date 28/08/2009 ID oral Recommended IDoral Units Justification n/a Classification — C; possible human carcinogen (IRIS). Group 2B - possibly carcinogenic to humans (IARC) Insufficient data Organisation Web Link Last Updated Date Web Checked Non threshold effects Basis Health criteria type Value Units Confidence rating Basis Study type International Agency for Research on Cancer http://inchem.org/pages/iarc.html 2004 09.04.09 Group 2B - possibly (IARC) carcinogenic to humans no data no data no data no data There is inadequate evidence in No data Animal Study humans for the carcinogenicity of (rat) hexachloroethane. USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ Feb-94 09.04.2009 C - Possible human carcinogen oral slope factor 0.0142 mg/kg/day Adequate numbers of animals were treated and tumor response was dose related. Background incidence of tumour is high. Extrapolation Method — Linearized multistage procedure, extra risk Animal (Rat). Carcinogenicity tests to mouse/B6C3F1, male & female. ID inhal Recommended Idinhal Units Justification n/a Classification — C; possible human carcinogen (IRIS). Group 2B - possibly carcinogenic to humans (IARC) Insufficient data Organisation Last Updated Non threshold effects Basis Health criteria type Value Units Confidence rating Basis Study type International Agency for Research on Cancer http://inchem.org/pages/iarc.html 2004 09.04.09 Group 2B - possibly (IARC) carcinogenic to humans no data no data no data no data There is inadequate evidence in No data Animal Study humans for the carcinogenicity of (rat) hexachloroethane. USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ Feb-94 09.04.2009 C - Possible human carcinogen oral slope factor 0.000004 (ug/m3) -1 Adequate numbers of animals were treated and tumor response was dose related. Background incidence of tumour is high. Extrapolation Method — Linearized multistage procedure, extra risk Animal (Rat). Carcinogenicity tests to mouse/B6C3F1, male & female.
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Hexachloroethane ID oral Organisation Description Response Reference Web link International Agency for Research on Cancer (IARC) no data After short-term exposure, International Chemical Safety Cards hexachloroethane caused renal toxicity in male rats and hepatocellular necrosis in both male and female rats. http://www.inchem.org/documents/icsc/icsc/eics0051.htm USEPA Integrated Risk Information System (IRIS) Tumor Type: Hepatocellular Carcinomas IRIS online database. Last updated in 2003. http://www.epa.gov/ncea/iris/subst/0167.htm ID inhal Organisation Description Response Reference Web link International Agency for Research on Cancer (IARC) no data After short-term exposure, International Chemical Safety Cards hexachloroethane caused renal toxicity in male rats and hepatocellular necrosis in both male and female rats. http://www.inchem.org/documents/icsc/icsc/eics0051.htm USEPA Integrated Risk Information System (IRIS) Tumor Type: Hepatocellular Carcinomas IRIS online database. Last updated in 2003. http://www.epa.gov/ncea/iris/subst/0167.htm
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