Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Hexachloroethane CAS Number: 67-72-1 Assessor A: A Fellows - Ecologia Assessor B: J Brown - DTS RaeFinal review: Panel/SF
Date 15.04.09 Date 16.04.09 Date 28/08/2009
ID oral
Recommended
IDoral Units Justification
n/a
Classification — C; possible human carcinogen (IRIS). Group 2B - possibly carcinogenic to humans (IARC) Insufficient data
Organisation Web Link Last Updated Date Web Checked Non threshold
effects
Basis
Health criteria
type
Value Units Confidence rating Basis Study type
International Agency for Research on Cancer http://inchem.org/pages/iarc.html 2004 09.04.09 Group 2B - possibly
(IARC)
carcinogenic to
humans
no data no data no data no data There is inadequate evidence in
No data
Animal Study
humans for the carcinogenicity of
(rat)
hexachloroethane.
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ Feb-94 09.04.2009 C - Possible human
carcinogen
oral slope factor 0.0142 mg/kg/day Adequate numbers of animals
were treated and tumor
response was dose related.
Background incidence of tumour
is high.
Extrapolation Method — Linearized multistage procedure, extra
risk
Animal (Rat).
Carcinogenicity
tests to
mouse/B6C3F1,
male & female.
ID inhal
Recommended
Idinhal Units Justification
n/a
Classification — C; possible human carcinogen (IRIS). Group 2B - possibly carcinogenic to humans (IARC) Insufficient data
Organisation Last Updated Non threshold
effects
Basis
Health criteria
type
Value Units Confidence rating Basis Study type
International Agency for Research on Cancer http://inchem.org/pages/iarc.html 2004 09.04.09 Group 2B - possibly
(IARC)
carcinogenic to
humans
no data no data no data no data There is inadequate evidence in
No data
Animal Study
humans for the carcinogenicity of
(rat)
hexachloroethane.
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ Feb-94 09.04.2009 C - Possible human
carcinogen
oral slope factor 0.000004 (ug/m3) -1 Adequate numbers of animals
were treated and tumor
response was dose related.
Background incidence of tumour
is high.
Extrapolation Method — Linearized multistage procedure, extra
risk
Animal (Rat).
Carcinogenicity
tests to
mouse/B6C3F1,
male & female.