Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Hexachloroethane
TDI oral
Organisation
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
Description Target organ/Critical Effect Reference Web link
Groups of 10 male and 10 female rats fed HCE liver and kidney weight increased ATSDR, Toxicological Profile For Hexachloroethane, 1997 http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf
in diet for 16 weeks
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
Groups of 5 male New Zealand rabbits treated
by gavage for 12 days.
liver degeneration and necrosis ATSDR, Toxicological Profile For Hexachloroethane, 1997 http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf
USEPA Health Advisors
USEPA Integrated Risk Information System
(IRIS)
no data no data EPA, 2006 Edition of the Drinking Water Standards and Health Advisories, http://www.epa.gov/waterscience/criteria/drinking/dwstandards.pdf
2006
Groups of 10 male and 10 female rats fed HCE
in diet for 16 weeks
liver and kidney weight increased IRIS online database, last updated in 2003 http://www.epa.gov/NCEA/iris/subst/0167.htm#carc
Toxicology Data Network (Toxnet)
Subchronic rat studies. In subchronic studies
kidney degeneration at 15 and 62 mg/kg
bw/day and increased kidney weights at 62
mg/kg were seen. Signs of kidney toxicity were
seen at 47 mg/kg bw/day.
Kidneys Nord Vol:15 (1999) pp 269-83 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~VYlc6H:5
TDI inhal
Organisation
Description Response Reference Web link
International Agency for Research on Cancer
(IARC)
International Programme on Chemical
Safety (IPCS)
In humans, exposure by inhalation to
hexachloroethane (10-20 mg/m3) produced
mild irritation of the skin and mucous
membrane.
Occupational Exposure Limit (DFG 2004).
Skin
The substance may have effects on the
liver and kidneys. Exposure at far above
the OEL may have effects on the central
nervous system, inducing tremors and
ataxia.
IARC Monographs on the evaluation of the carcinogenic risk of chemicals to
humans Vol:73 (1999) pp 295-306
International Chemical Safety Cards
http://www.inchem.org/documents/iarc/vol73/73-10.html
http://www.inchem.org/documents/icsc/icsc/eics0051.htm
Dutch National Institute for Public Health
Health Canada Toicological Values
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
N/A N/A N/A N/A
LOEC for development toxicity. LOEC for short
term repeated dose toxicity = 2517mg/m3
(different study)
Groups of 25 male and female rates subjected
to 0, 15, 48 and 260 ppm for 6 hrs/day, 5
days/week for 6 weeks.
Groups of 22 pregnant rats exposed to vapours
for 6 hrs day on gestation days 6-16.
Health Canada, State of the Science Report for a Screening Health
Assessment – Hexachloroethane, 2005
Reduced body weight, eye irritation, ATSDR, Toxicological Profile For Hexachloroethane, 1997
tremors and reduced infection resistance.
Reduced body weight, eye irritation, ATSDR, Toxicological Profile For Hexachloroethane, 1997
tremors and reduced infection resistance.
http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/hexachloroethane/hexachloroethane-eng.pdf
http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf
http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf