Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

More documents

Recommendations

Info

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Hexachloroethane CAS Number: 67-72-1 Assessor A: A Fellows - Ecologia Assessor B: J Brown - DTS RaeFinal review: Panel/SF Date 15.04.09 Date 16.04.09 Date 28/08/2009 Apply TDIoral to exposure routes Apply IDoral to exposoure routes Apply TDIinh to exposure routes Apply IDinh to exposure routes Oral Dermal Inhalation Yes Yes Yes No No No No No No No No No Justification Group C carcinogen (IRIS), Insufficient evidence to be a human carcinogen - TDIoral applied to oral and dermal routes Group C carcinogen (IRIS), Insufficient evidence to be a human carcinogen. Insufficient data to allow formulation of inhalation TDI. TDIoral applied to inhalation exposure routes. TDI oral Recommended TDIoral Initial Units CLEA Units Justification 1 mg/kg/day ug.kg-1.d-1 most conservative value (USEPA and IRIS) Organisation Web Link Last Updated Date Web Checked Health criteria type Value Units Units Confidence Basis Value Units UF UF description Study type US Agency for Toxic Substances and Disease http://www.atsdr.cdc.gov/ Sep-97 06/04/2009 MRL intermediate 0.01 mg/kg/day 10 no data NOAEL 1 mg/kg/day 100 10 for extropaltion from animals to rats Registry (ATDSR) Toxicological Profiles and Minimal Risk levels humans, 10 for inter human variability US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels http://www.atsdr.cdc.gov/ Sep-97 06/04/2009 MRL acute 1 mg/kg/day 1000 no data NOAEL 100 mg/kg/day 100 10 for extrapolation form animals to humans, 10 for human variability rabbits USEPA Health Advisors USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/waterscience/criteria/ drinking Aug-06 06/04/2009 RFD 0.001 mg/kg/day 1 no data no data no data no data no data no data no data http://epa.gov/iris/ 01/01/1991 06/04/2009 RFD 0.001 mg/kg/day 1 Medium NOEL 1 mg/kg/day 1000 10 to account for interspecies rats extrapolation, 10 for the range of sensitivity within the human population to xenobiotics and 10 for the use of a subchronic study. Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ 1999 14.04.09 TDI 0.0047 mg/kg/day 4.7 LOAEL 0.0047 mg/kg/day 10000 10 for animals to humans, 10 for human variability, 10 for non-chronic study and 10 for LOAEL Sub-chronic oral TDI inhal Recommended TDIinhal Initial Units CLEA Units Justification n/a n/a ug.kg-1.d-1 Current studies undertaken considered insufficient for derivation of TDI Inhalation. Using Oral Extrapolation. Organisation Last Updated Health criteria type Value Units Confidence rating Basis Value Units UF UF description Study type International Agency for Research on Cancer http://inchem.org/pages/iarc.html 1999 14.04.09 TDI 10 mg/m3 no data LOAEL 10 mg/m3 no data no data Acute - Short (IARC) term repeated dose International Programme on Chemical Safety (IPCS) http://www.who.int/ipcs/en/ 2004 14/04/2009 MAK - Maximum Workplace Concentration 9.8 mg/m3 2.8 no data no data 9.8 mg/m3 no data no data Animal Study (rat) Dutch National Institute for Public Health http://www.rivm.nl/en/ N/A 14/04/2009 N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Health Canada Toicological Values http://www.hc-sc.gc.ca/index_e.html Jun-05 06.04.09 no data no data no data no data no data LOEC 465 mg/m3 no data no data female rats US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels http://www.atsdr.cdc.gov/ Sep-97 14.04.09 MRL intermediate 6 ppm no data NOAEL 48 ppm 30 10 for human variability, 3 for animal - Intermediate - human extrapolation Animal Study http://www.atsdr.cdc.gov/ Sep-97 14.04.09 MRL acute 6 ppm no data NOAEL 48 ppm 30 10 for human variability, 3 for animal - Acute - Animal human extrapolation. Converted for Study humans by 48 ppm (0.22 m3/day/0.204kg) / 20 m3/day/70kg) = 181 ppm
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Hexachloroethane TDI oral Organisation US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels Description Target organ/Critical Effect Reference Web link Groups of 10 male and 10 female rats fed HCE liver and kidney weight increased ATSDR, Toxicological Profile For Hexachloroethane, 1997 http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf in diet for 16 weeks US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels Groups of 5 male New Zealand rabbits treated by gavage for 12 days. liver degeneration and necrosis ATSDR, Toxicological Profile For Hexachloroethane, 1997 http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf USEPA Health Advisors USEPA Integrated Risk Information System (IRIS) no data no data EPA, 2006 Edition of the Drinking Water Standards and Health Advisories, http://www.epa.gov/waterscience/criteria/drinking/dwstandards.pdf 2006 Groups of 10 male and 10 female rats fed HCE in diet for 16 weeks liver and kidney weight increased IRIS online database, last updated in 2003 http://www.epa.gov/NCEA/iris/subst/0167.htm#carc Toxicology Data Network (Toxnet) Subchronic rat studies. In subchronic studies kidney degeneration at 15 and 62 mg/kg bw/day and increased kidney weights at 62 mg/kg were seen. Signs of kidney toxicity were seen at 47 mg/kg bw/day. Kidneys Nord Vol:15 (1999) pp 269-83 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~VYlc6H:5 TDI inhal Organisation Description Response Reference Web link International Agency for Research on Cancer (IARC) International Programme on Chemical Safety (IPCS) In humans, exposure by inhalation to hexachloroethane (10-20 mg/m3) produced mild irritation of the skin and mucous membrane. Occupational Exposure Limit (DFG 2004). Skin The substance may have effects on the liver and kidneys. Exposure at far above the OEL may have effects on the central nervous system, inducing tremors and ataxia. IARC Monographs on the evaluation of the carcinogenic risk of chemicals to humans Vol:73 (1999) pp 295-306 International Chemical Safety Cards http://www.inchem.org/documents/iarc/vol73/73-10.html http://www.inchem.org/documents/icsc/icsc/eics0051.htm Dutch National Institute for Public Health Health Canada Toicological Values US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels N/A N/A N/A N/A LOEC for development toxicity. LOEC for short term repeated dose toxicity = 2517mg/m3 (different study) Groups of 25 male and female rates subjected to 0, 15, 48 and 260 ppm for 6 hrs/day, 5 days/week for 6 weeks. Groups of 22 pregnant rats exposed to vapours for 6 hrs day on gestation days 6-16. Health Canada, State of the Science Report for a Screening Health Assessment – Hexachloroethane, 2005 Reduced body weight, eye irritation, ATSDR, Toxicological Profile For Hexachloroethane, 1997 tremors and reduced infection resistance. Reduced body weight, eye irritation, ATSDR, Toxicological Profile For Hexachloroethane, 1997 tremors and reduced infection resistance. http://www.hc-sc.gc.ca/ewh-semt/alt_formats/hecssesc/pdf/pubs/contaminants/hexachloroethane/hexachloroethane-eng.pdf http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf http://www.atsdr.cdc.gov/toxprofiles/tp97.pdf
Page 1 and 2:
www.esdat.net Esdat Environmental D
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
1,3,5-Trimethylbenzene CAS 108-67-8
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140:
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
Page 187 and 188:
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
Page 199 and 200:
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
Page 211 and 212: www.esdat.net Esdat Environmental D
Page 261: www.esdat.net Esdat Environmental D
Page 313 and 314:
Page 315 and 316:
Page 317 and 318:
Page 319 and 320:
Page 321:
show all

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?