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Di-n-octyl phthalate CAS 117-84-0 Assessor A: B Mitcheson, Enviros Assessor B: Simon Cole, URS Final review: Panel/SF
Date 05/05/2009 Date 10/08/2009 Date 09/09/2009
MDI Recommended MDIoral Units
210 ug day-1
Based on NTP comment that DnOP exposure significantly less than DEHP. Thus, exposure assumed not to exceed 3 ug/kg/d. Converted assuming a 70kg adult to 210 ug/d for
an adult.
Organisation Date Media Value Units Description Reference Web link
Food Standards Agency 1993 Diet Diet data for combined phthalates. Majority appears to be
diethylhexylphthalate. (Conc DEHP is the same as Total DOPs
for carcass meat and eggs but total DOP in milk is 2.6mg/kg but
DEHP is 0.3mg/kg)
82: MAFF UK - Phthalates in Food (March
1996) Table 2: Estimated mean and high level
(97.5th percentile) intakes of individual
phthalates from carcass meat, poultry, eggs
and milk, based on the analysis of 1993 Total
Diet Study samples.
http://archive.food.gov.uk/maff/archive/food/infsheet/1996/no8
2/table2.htm#Table2
Committee on Toxicity of Chemicals
in Food, Consumer Products and the
Environment (COT)
SCIENTIFIC COMMITTEE ON
CONSUMERS PRODUCTS (SCCP)
12/04/2009 There may be stability issues with the phthalate analysis. The
phthalate data previously presented to the COT are therefore
considered to be unreliable. This may cast doubt on the FSA
data from 1993 and 1998)
COMMITTEE ON TOXICITY OF CHEMICALS IN
FOOD, CONSUMER PRODUCTS AND THE
ENVIRONMENT. TOXICOLOGICAL
EVALUATION OF A PILOT STUDY FOR A
BREAST MILK ARCHIVE. TOX/2004/14. April
2004
16/05/2009 not detected in study Request for a scientific opinion: Phthalates in
Cosmetics
http://cot.food.gov.uk/pdfs/TOX-2004-14.pdf
http://ec.europa.eu/health/ph_risk/committees/04_sccp/docs/sc
cp_q_156.pdf
Leaching from toys 296 ug day-1
Toxicological Data Network
(TOXNET)
Entrez PubMed
12/04/2009 Water 0.0728 mg/year Average Daily Intake: The estimated mean human exposure to
dioctyl phthalate via drinking water in Toronto, Canada is
0.0728 mg/year
12/04/2009 Comment on overall
exposure
< 3 ug/kg/d The available data do not allow the confident estimation of
DnOP exposures to the general population. However, a
comparison of production volumes for DnOP-containing
compounds versus those that contain DEHP suggests that
human exposure to DnOP is well below the exposure estimate
children due to dietary preferences or mouthing of DnOPcontaining
articles
Davies K; Adv Environ Sci Technol 23: 525-40
(1990)
NTP-CERHR Monograph on the Potential
Human Reproductive and Developmental
Effects of Di-n -Octyl Phthalate (DnOP) May
2003
http://toxnet.nlm.nih.gov/
www.ncbi.nlm.nih.gov/entrez/query.fcgi
MDI Recommended MDIinh Units
0.01 ug day-1
Midpoint concentration from ATSDR data (0.5 ng/m3) x assumed adult inhalation rate of 20 m3/d / 1000 ng/ug gives an estimated MDI of 0.01 ug.d-1.
Organisation Date Media Value Units Description Reference Web link
US Agency for Toxic Substances and
Disease Registry (ATSDR)
Toxicological Profiles and Minimal
Risk Levels
12/04/2009 Air 0.06 to 0.94 ng/m3 Di-n-octyl phthalate detected in 5 of 7 ambient air samples
taken in Feb 1984 Portland, Oregon, USA. Detected concs
ranged from 0.06 to 0.94 ng/m3.
www.atsdr.cdc.gov/
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