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Di-n-octyl phthalate CAS Number: 117-84-0
Assessor A:
European Food Safety Authority (EFSA) http://www.efsa.europa.eu/en.html Report from 2005 07/04/2009 No comment on
carcinogenicity
B Mitcheson,
Enviros
Assessor B: S Cole, URS Final review: Panel/SF
Date 05/05/2009 Date 10/08/2009 Date 09/09/2009
International Agency for Research on Cancer
(IARC)
http://inchem.org/pages/iarc.html
16/05/2009 No data
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/
2000
14/01/2009 for MRL
page (And report June
2002)
16/05/2009
Di-n-octylphthalate has
not been classified for
carcinogenic effects by
the Department of
Health and Human
Services, the
International Agency for
Research on Cancer, or
the EPA.
ID inhal
Recommended ID
inhal
n/a
Units
Justification
Weight of evidence indicates unlikely carcinogenic.
Organisation Web Link Last Updated Date Web Checked Non threshold effects Basis Health criteria type Value Units Confidence rating
Basis
Study type
Food Standards Agency (FSA)
Health Protection Agency (HPA)
http://www.food.gov.uk/
http://www.hpa.org.uk/
Friday 5 August 2005 (On
11-Sep-08
European Chemicals Bureau (ECB) http://ecb.jrc.it/ Date of Last Literature
Search : 2005. Review
of report by MS
Technical Experts
finalised: September
2005. Final report: 2008
31/03/2009
No data on inhalation
doses identified. Site
refers to endocrine
disruptors not
carcinogens.
31/03/2009 Page on exposure
standards details no
drinking water standard
no soil standard or air
standard
07/04/2009 No data
European Food Safety Authority (EFSA) http://www.efsa.europa.eu/en.html Report from 2005 07/04/2009 No data
International Agency for Research on Cancer
(IARC)
http://inchem.org/pages/iarc.html
07/04/2009 No data
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/
2000
14/01/2009 for MRL
page (And report June
2002)
08/04/2009 No studies were located regarding geotaxis effects in humans
after inhalation, oral, or dermal exposure to DEHP. As discussed
below, DEHP has been extensively tested in a variety of shortterm
genotoxicity assays with predominantly negative or falsepositive
results. The weight of evidence from these assays, as well
as the tumour initiating/promoting activity studies summarized in
Section 3.5.2 (Mechanisms of Toxicity), indicate that DEHP does
not induce lesions in nuclear DNA, is not mutagenic/geotaxis, and
is not a tumour initiator, but rather that it is a rodent liver
mutagen and tumour promoter, and is best characterized as an
epigenetic toxicant.
Page 5 of 6 EIC proforma di-n-octylphthalate 09/09/2009