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Di n butyl phthalate, Di butyl phthalate or
DBP
Food Standards Agency (FSA)
Not data on inhalation dose. Reference make to
endocrine disruptors. Site relates to contact with food
http://www.food.gov.uk/foodlabelling/packagingbranch/phthalates/ &
http://www.eatwell.gov.uk/healthissues/factsbehindissues/phthalates/lan
g=en & http://cot.food.gov.uk/pdfs/TOX-
2004-14.pdf SCF (1996). Phthalates in infant formulae (Opinion expressed
on 7 June
1996). Reports of the Scientific Committee on Food, 36th Series. Available
at: http://europa.eu.int/comm/food/fs/sc/scf/reports_en.html
Health and Safety Executive (HSE)
Risk Phrases refer to R60 and R61 (harm
fertility and harm the unborn child) and
R50 toxic to aquatic organisms
HSC/04/06 Annex C
http://www.hse.gov.uk/aboutus/meetings/hscarchive/2004/091104/c06c.p
df
European Chemicals Bureau (ECB)
Rat, 28-day
inhalation
Study in line with current good practise. Further notes Upper respiratory tract (local effect)
on UF: Because an inhalation study is used a factor for
allometric scaling is not necessary, and a factor 3 is
applicable. A factor for extrapolation of exposure
duration is not considered necessary since it is
assumed that exposure duration will only have
influence on the severity of the effects and not on the
level of toxicity c) A factor 3 is introduced for the
extrapolation of a LOAEC to a NOAEC
European Union Risk Assessment Report Volume 29 , 2003 with addendum
2004. Refers to Gamer et al., 2000.
http://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-
Chemicals/RISK_ASSESSMENT/REPORT/dibutylphthalatereport003.pdf
Joint FAO/WHO Meeting on Pesticide
Residues (JMPR)
reference to phthalates only relate to DMP as solvent
for dermal test and DEHP and an interference
JMPR 2
reference to phthalates only relate to DMP as solvent
for dermal test and DEHP and an interference
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
USEPA Health Advisors
Baars et al states that inhalation not considered
relevant due to low volatility. The dust paper uses the
oral EFSA value given above
re-evaluation of maximum permissible levels By Baars et al RIVM
711701025/2001 superseded by RIVM Report 609021064/2008 Exposure to
chemicals via house dust A. G. Oomen P. J.C.M. Janssen A. Dusseldorp C. W.
Noorlander
http://www.rivm.nl/bibliotheek/rapporten/609021064.pdf &
http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf (Baars et al)
USEPA Integrated Risk Information System
(IRIS)
ID oral
The health effects data for dibutyl phthalate were
reviewed by the U.S. EPA RfD/RfC Work Group and
determined to be inadequate for derivation of an
inhalation RfC.
http://www.epa.gov/ncea/iris/subst/0038.htm
Organisation
Food Standards Agency (FSA)
Study type Description Response Reference Web link
http://www.food.gov.uk/foodlabelling/packagingbranch/phthalates/ &
http://www.eatwell.gov.uk/healthissues/factsbehindissues/phthalates/lan
g=en & http://cot.food.gov.uk/pdfs/TOX-
2004-14.pdf SCF (1996). Phthalates in infant formulae (Opinion expressed
on 7 June
1996). Reports of the Scientific Committee on Food, 36th Series. Available
at: http://europa.eu.int/comm/food/fs/sc/scf/reports_en.html
European Chemicals Bureau (ECB)
European Union Risk Assessment Report Volume 29 , 2003 with addendum
2004
http://ecb.jrc.ec.europa.eu/DOCUMENTS/Existing-
Chemicals/RISK_ASSESSMENT/REPORT/dibutylphthalatereport003.pdf
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
Health Canada Toxicological Values
Carcinogenicity is potentially the most sensitive
endpoint. The weight of available data in in vitro
assays indicates that dibutyl phthalate is not genotoxic.
No human epidemiological studies to assess
carcinogenicity and available data considered
inadequate to assess the carcinogenicity animals.
re-evaluation of maximum permissible levels By Baars et al RIVM
http://www.rivm.nl/bibliotheek/rapporten/609021064.pdf &
711701025/2001 superseded by RIVM Report 609021064/2008 Exposure to http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf (Baars et al)
chemicals via house dust A. G. Oomen P. J.C.M. Janssen A. Dusseldorp C. W.
Noorlander
Dibutyl Phthalate - PSL1
http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1-
lsp1/phthalate_dibutyl_phtalate/phthalate_dibutyl_phtalate_3-eng.php
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