Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Di methyl phthalate Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels TDI of dimethyl phthalate (DMP) is unknown as the compound is chemically comparable to diethyl phthalate (DEP), the concentrations of DMP are added to the concentrations of DEP and compared to the TDI of DEP. 200ug/kgbw/day Re-evaluation of human-toxicological Maximum Permissible Levels. Report no. 711701025, http://www.rivm.nl/bibliotheek/rapporten/609021064.pdf & http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf (Baars et al) Toxicology Data Network (Toxnet) Maternal toxicity Developmental Toxicity of Dimethyl phthalate (CAS No. 131-11-3) Administered to CD Rats on Gestational Days 6 Through 15 development toxicity Developmental Toxicity of Dimethyl phthalate (CAS No. 131-11-3) Administered to CD Rats on Gestational Days 6 Through 15 http://ntp.niehs.nih.gov/index.cfmobjectid=07305BCA-A86E-545E- 0669D64152F6C5BC http://ntp.niehs.nih.gov/index.cfmobjectid=07305BCA-A86E-545E- 0669D64152F6C5BC TDI inhal Organisation Drinking Water Inspectorate (DWI) Description Response Reference Web link No dose data identified - searched for plasticiser, phthalate, dicarboxylic. Note that tests for plastic pipes must comply with BS 6920 which includes a flavour and odour test Food Standards Agency (FSA) Not data on inhalation dose. Reference make to endocrine disruptors. Site relates to contact with food http://www.food.gov.uk/foodlabelling/packagingbranch/phthalates/ & http://www.eatwell.gov.uk/healthissues/factsbehindissues/phthalates/lang =en & http://cot.food.gov.uk/pdfs/TOX-2004- 14.pdf SCF (1996). Phthalates in infant formulae (Opinion expressed on 7 June 1996). Reports of the Scientific Committee on Food, 36th Series. Available at: http://europa.eu.int/comm/food/fs/sc/scf/reports_en.html Health and Safety Executive (HSE) http://www.hse.gov.uk/aboutus/meetings/hscarchive/2004/091104/c06c.p df IPCS INCHEM Joint FAO/WHO Meeting on Pesticide Residues (JMPR) JMPR 2 Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels reference to phthalates only relate to DMP as solvent for dermal test and DEHP and as interference reference to phthalates only relate to DMP as solvent for dermal test and DEHP and as interference No assessment of inhalation due to low volatility, but Oral dose for DEP used for dust inhalation in paper. Di methyl phthalate ICSC 0261 Re-evaluation of human toxicological maximum permissible levels (Baars 2001) http://www.inchem.org/documents/icsc/icsc/eics0261.htm http://www.rivm.nl/bibliotheek/rapporten/609021064.pdf & http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf (Baars et al) Toxicology Data Network (Toxnet) Toxicology of esters of O-phthalic acid and hygienic standards for them. GIG TR PROF ZABOL; 0 (3). 1980. 28-29 Occupational Health Standards - OSHA from HSDB Occupational Health Standards - NOISH from HSDB Occupational Health Standards - NOISH from HSDB http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~ggmhOT:21 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~eWqfYa:7 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~eWqfYa:7 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~eWqfYa:7 Page 4 of 6 EIC proforma dimethyl phthalate.xls08/09/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Di methyl phthalate CAS Number: 131-11-3 Assessor A: Barry Mitcheson, Assessor B: Alison Pugh, Final review: Panel/SF Enviros Hyder Date 05/05/2009 Date 06/05/2009 Date 08/09/2009 ID oral Recommended ID oral CLEA Units Justification n/a Insufficient evidence for classification Organisation Last Updated Non threshold effects Basis Health criteria type Drinking Water Inspectorate (DWI) http://www.dwi.gov.uk/ 31-Mar-09 Value Units Confidence rating Basis Study type 31-Mar-09 Food Standards Agency (FSA) http://www.food.gov.uk/ Friday 5 August 2005 (One 31/03/2009 Scientific Committee on Food (SCF) pre 2002 http://ec.europa.eu/food/fs/sc/scf/index_en. html 07/04/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 08/04/2009 01/02/1990 (database last commented in 1998) CLEA Units ID inhal Recommended Id inhal n/a Organisation Last Updated Non threshold effects Basis Health criteria type Justification Insufficient evidence for classification Value Units Confidence rating Basis Study type Health and Safety Executive (HSE) http://www.hse.gov.uk/ 06/04/2009 Scientific Committee on Food (SCF) pre 2002 http://ec.europa.eu/food/fs/sc/scf/index_en. html 07/04/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 01/02/1990 (database last commented in 1998) 08/04/2009 Page 5 of 6 EIC proforma dimethyl phthalate.xls08/09/2009
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