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Di methyl phthalate
TDI oral
Organisation
Description Target organ/Critical Effect Reference Web link
Food Standards Agency (FSA)
Refence to Endocrine disruptors on infromaiton
page. The site states that the European Food
Safety Authority reviews all the scientific data in
order to set a tolerable daily intake. This is an
estimate of the amount of a substance in food or
drinking water that can be consumed daily by
people over a lifetime without any appreciable
risk to health.
http://www.food.gov.uk/foodlabelling/packagingbranch/phthalates/ &
http://www.eatwell.gov.uk/healthissues/factsbehindissues/phthalates/lang
=en & http://cot.food.gov.uk/pdfs/TOX-2004-
14.pdf SCF (1996). Phthalates in infant formulae (Opinion expressed on 7
June
1996). Reports of the Scientific Committee on Food, 36th Series. Available
at: http://europa.eu.int/comm/food/fs/sc/scf/reports_en.html
Committee on the Toxicity of Chemicals in
Food, Consumer Products and the
Environment (COT)
Scientific Committee on Food (SCF) pre 2002
Reference made in Jul 1996 STATEMENT ON
PHTHALATES IN INFANT
FORMULAE to Tolerable Daily Intakes (TDIs) set
by the EC Scientific Committee for Food for a
group restriction of 0.05mg/kg bw/day.
Phthalates in infant formulae (Opinion
expressed on 7 June 1996). Reports of the
Scientific Committee on Food, 36th Series.
These exceed by 2-3 fold the temporary "group
restriction" of 0.05
mg/kg bodyweight/day set by the SCF for those
phthalates for which further toxicity
testing is required. The Committee notes that
TDIs are derived from doses which
produce no effect in animal studies
Available limited oral rat chronic
toxicity/carcinogenicity, oral teratogenicity
studies in rats and mice, Ames test. . Needed :
gene mutation and chromosome aberration in
mammalian cells in vitro and migration data in
the first instance
Jul 1996 STATEMENT ON PHTHALATES IN INFANT
FORMULAE Variability and Uncertainty in Toxicology of Chemicals in Food,
Consumer Products and the Environment March 2007 looks at phthalate
esters as endocrine modulators affecting testes and exposure of rats during
pregnancy to high levels of certain
phthalate esters is able to induce in the male offspring a collection of
disorders that is remarkably similar to Testicular Dysgenesis Syndrome in
humans and in foetal life a substantial reduction in anogenital distances.
also in TOX/2003/09 COMMITTEE ON TOXICITY OF CHEMICALS IN FOOD,
CONSUMER PRODUCTS AND THE ENVIRONMENT ADVERSE TRENDS IN
DEVELOPMENT OF THE MALE REPRODUCTIVE SYSTEM - POTENTIAL
CHEMICAL CAUSES 2003 and annual report 2006)
http://cot.food.gov.uk/pdfs/cotstatementphthalates96.pdf also in
http://cot.food.gov.uk/pdfs/TOX-2004-14.pdf referring to SCF (1996).
Phthalates in infant formulae (Opinion expressed on 7 June 1996). Reports of
the Scientific Committee on Food, 36th Series. Available at:
http://europa.eu.int/comm/food/fs/sc/scf/reports_en.html
(Other sites with no dose data
http://cot.food.gov.uk/pdfs/vutreportmarch2007.pdf ,
http://cot.food.gov.uk/pdfs/2003-09endocrine.PDF,
http://cot.food.gov.uk/pdfs/cotsection06.pdf )
Compilation of the Evaluations of the scientific committee on food on certain http://ec.europa.eu/food/fs/sc/scf/reports/scf_reports_42.pdf
monomers and additives used in the manufacture of plastics materials
intended to come into contact with food Stuffs Until 21 March 1997 SCF 1999
WHO Guidelines for drinking water Quality
mg of toxicant per kg bw required to kill 50% of
large population of test animals. Used in
repellant. In table 5 which is for active
ingrediantes unlikely to present active hazard in
normal use
The WHO recommended classification of pesticides by hazard and guidelines
to classification : 2004.
http://www.who.int/ipcs/publications/pesticides_hazard_rev_3.pdf
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EIC proforma dimethyl phthalate.xls08/09/2009