Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Di methyl phthalate CAS Number: 131-11-3 Assessor A: Barry Mitcheson, Assessor B: Alison Pugh, Final review: Panel/SF
Enviros
Hyder
Date 05/05/2009 Date 06/05/2009 Date 08/09/2009
Apply TDIoral to exposure routes
Apply IDoral to exposoure routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
Oral Dermal Inhalation
No No No
No No No
No No No
No No No
Justification
No strong evidence to be a human carcinogen -
Insufficient data to derive TDI
No strong evidence to be a human carcinogen -
Insufficient data to derive TDI
TDI oral
Recommended TDI oral CLEA Units
n/a
ug.kg-1.d-1
Justification
No suitable study identified. Consideration given to use of DEP as surrogate, as set out by RIVM in report on dust exposure but toxic mechanism of DMP not
known, consideration also given to group restriction on all phthalates. Careful consideration should be given to potential additive effects of different
phthalates when setting HCVs.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
Confidence rating Basis Value Units UF UF description Study type
Food Standards Agency (FSA) http://www.food.gov.uk/ Friday 5 August 2005
(One site date not given)
31/03/2009
Committee on the Toxicity of Chemicals in
Food, Consumer Products and the
Environment (COT)
http://cot.food.gov.uk/
29/4/8 (uploaded
infant milk formula
file from July 2006)
06/04/2009 TDI
0.05 mg/kgbw/day
50 The Committee
was aware that
new evidence on
the reproductive
effects of
phthalates has
been published
since this TDI was
set.
100 SCF not details given NOAEL
Scientific Committee on Food (SCF) pre 2002 http://ec.europa.eu/food/fs/sc/scf/index_en.
html
1999 07/04/2009 TDI tabulated 0.05 mg/kgbw/day 50
WHO Guidelines for drinking water Quality
http://www.who.int/water_sanitation_health copyright 2005 19/04/2009 LD50 8200 mg/kg bw
/dwq/guidelines/en
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EIC proforma dimethyl phthalate.xls08/09/2009