Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Diethylphthalate CAS 84-66-2 Assessor A: Gareth Wills Assessor B: Mat Rouge Final Review: Panel/SF Date 08/04/2009 Date 15/04/2009 Date 26/08/2009 MDI Recommended Units MDIoral 80.5 ug day-1 Justification: relatively new (Ursel et al. 2007) study, mean exposure to 8 phthalates in 5 consumer groups. Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents 2000 Surface Water 1 ug day-1 In a compilation of concentrations (1984–1997) of diethyl phthalate in North American and western Staples CA, Parkerton TF, Peterson DR (2000) A risk assessment of selected phthalate esters in North American and Western European surface waters. http://inchem.org/documents/cicads/cicads/cicad52.htm (CICADs) European surface waters (USA, Canada, United Kingdom, Chemosphere , 40:885–891 Germany, Netherlands, Sweden), geometric mean concentrations ranged from about 0.01 to 0.5 μg/litre (Staples et al., 2000). Using the highest mean the average daily intake through water consumption would be 1 ug day (Using the CLEA calculation of 2 litres per day intake) 2001 Food 0.35 ug day-1 In a duplicate-portion study, Tsumura et al. (2001) Tsumura Y, Ishimitsu S, Saito I, Sakai H, Kobayashi Y, Tonogai Y (2001) Eleven estimated daily intake of 11 phthalate esters, including phthalate esters and di(2-ethylhexyl)adipate in one-week duplicate diet diethyl phthalate and di(2-ethylhexyl) adipate, in 1-week samples obtained from hospitals and their estimates of daily intake. Food total diet samples provided in hospitals. Portions of Additives and Contaminants , 18(5):449–460 meals of breakfast, lunch, and supper were obtained from three hospitals located in three areas in Japan in October or December 1999, for a period of 7 days. Recovery of the spiked samples and quality assurance of analysis were performed at three laboratories. Daily intakes of diethyl phthalate were 0.07–1.41 μg/person (samples in which diethyl phthalate was not detected were assumed to contain diethyl phthalate at 50% of the limit of detection, which was 0.1, 0.2, and 0.5 ng/g for the three participating laboratories after subtraction of the blank value). Average daily intakes in the three hospitals were estimated to be 0.10, 0.28, and 0.67 μg (overall average 0.35 μg) per day per person, respectively http://inchem.org/documents/cicads/cicads/cicad52.htm US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk Levels 1976 Drinking Water 0.2 ug day-1 Diethyl phthalate was found in the finished drinking Keith et al 1976. Identification of organic compounds in drinking water from thirteen US cities.In:Keith LH,ed. Identification and analysis of organic (Seattle, Washington; Philadelphia, Pennsylvania; New pollutants in water. Ann Arbor, M1: Ann Arbor Press, 329-373 York, New York) Based on this concentration the daily intake is calculated to be 0.2 ug day, assuming 2 litres intake a day. 1991 Food 4000 ug day-1 Estimated to be 4mg day based on a consumption of 1kg of food wrapped in cellulose acetate containing diethyl phthalate at a concentration of 4 mg/kg (Karmin and Mayor, 1991) Kamrin MA, Mayor GH. 1991. Diethyl Phthalate - a perspective. J Clin Pharmacol 31(5):484-489 http://www.atsdr.cdc.gov/toxprofiles/tp73.html http://www.atsdr.cdc.gov/toxprofiles/tp73.html Entrez PubMed 2003 Total Intake 1547 ug day-1 A study on the German population found that the 95th percentile of the population studied had an intake of diethylphthalate of 22.1 ug/kg bw/day. The study used excreted metabolites in urine to determine the intake concentration of the individual. Koch HM, Drexler H, Angerer J, (2003) An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population, International Journal Hyg Environmental Health. 2003 Mar;206(2):77-83 www.ncbi.nlm.nih.gov/entrez/query.fcgi Other 2007 Total Intake 80.5 ug day-1 bodyweight day) in 5 consumer groups, mean and maximal exposure – estimations based on ambient monitoring and scenario calculations for uptake of food, air, water, consumer products, household dust, leaching from toys, etc. Adult mean daily intake of diethyl phthalate was 1.15 ug/kg bw/day with the maximum being 50.94. Using the 1.15 value a daily intake has been calculated as 80.5 ug day Ursel Heudorf, Volker Mersch-Sundermann and Jürgen Angerer (2007), Phthalates: Toxicology and exposure International Journal of Hygiene and Environmental Health Volume 210, Issue 5, 31 October 2007, Pages 623-634, Children's Environment in Central Europe - Threats and Chances - Results of an International Workshop held on November 21-24, 2006 in Osnabrück http://www.sciencedirect.com/science_ob=ArticleURL& _udi=B7GVY-4PPWMN9- 3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_d ocanchor=&view=c&_acct=C000050221&_version=1&_url Version=0&_userid=10&md5=24db0bb7c2fd9a3feb87b30f 3af5d14d MAFF 1996 Food 100 - 800 ug day-1 MAFF Food Surveillance Information Sheet 82. Total Diet Study identified between 0.1 to 0.8 mg/day exposure to total phthalates within food http://archive.food.gov.uk/maff/archive/food/infsheet/19 96/no82/82phthal.htm (Page 1 of 2) (EIC proforma diethyl phthalate.xls 26/08/2009)

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Diethylphthalate CAS 84-66-2 Assessor A: Gareth Wills Assessor B: Mat Rouge Final Review: Panel/SF Date 08/04/2009 Date 15/04/2009 Date 26/08/2009 MDI Recommended MDIinh Units 2 ug day-1 Justification: Although value is based upon indoor air study in Japan (Takamitsu Otake, Jun Yoshinaga and Yukio Yanagisawa), alternative values are based on monitoring at known DEP source zones, and therefore overly estimate exposure. Converted from 0.1μg/m3 assuming 20m3/day air inhaled. Organisation Date Media Value Units Description Reference Web link IPCS Concise International 1987 Indoor Air 40.6 ug day-1 Diethyl phthalate has been measured in the indoor air of Shields HC, Weschler CJ (1987) Analysis of ambient concentrations of organic http://inchem.org/documents/cicads/cicads/cicad52.htm Chemical Assessment Documents (CICADs) a telephone switching office and in outdoor air in Newark, USA, at concentrations ranging from 1.60 to 2.03 μg/m 3 and from 0.40 to 0.52 μg/m 3 , respectively, during a 43-day sampling period (Shields & Weschler, 1987) - which taking the highest recorded value converts to a daily intake of 40.6 ug day using the CLEA intake value of 20 m3 per day vapors with a passive sampler. Journal of the Air Pollution Control Association , 37(9):1039–1045 Toxicological Data Network (TOXNET) 1984 Ambient Air 0.002 ug day-1 Diethyl phthalate was detected in the atmosphere over Giam CS et al; in Handbook of Environmental Chemistry; Anthropogenic Barrow, AK at concns of 0.1 ng/cu m - which converts to Substances. Berlin, Germany: Springer-Verlag pp. 67-142 (1984) 0.002 ug day using the CLEA intake value of 20 m3 per day Other 24-Mar-04 Indoor Air 0.1 ug/m3 (equates to 2 Phthalate esters and phosphate esters in samples of indoor air from 27 houses in the Tokyo Metropolitan ug/d, assuming area were quantified using gas chromatograph/mass 20m3 air inhaled/d) spectrometer and gas chromatograph/flame photometric detector after adsorption on to charcoal and solvent extraction. The median concentrations of diethyl phthalate, dibutyl phthalate (DBP), butylbenzyl phthalate, dicyclohexyl phthalate and diethylhexyl phthalate were 0.10, 0.39, 0.01, 0.07 and 0.11 μg/m3, respectively. Takamitsu Otake, Jun Yoshinaga and Yukio Yanagisawa. Journal of Exposure Analysis and Environmental Epidemiology (2004) 14, 524–528. doi:10.1038/sj.jea.7500352 Published online 24 March 2004 http://toxnet.nlm.nih.gov/ http://www.nature.com/jes/journal/v14/n7/full/7500352 a.html (Page 2 of 2) (EIC proforma diethyl phthalate.xls 26/08/2009)

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