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Diethylphthalate CAS 84-66-2 Assessor A: Gareth Wills Assessor B: Mat Rouge Final Review: Panel/SF
Date 08/04/2009 Date 15/04/2009 Date 26/08/2009
MDI
Recommended Units
MDIoral
80.5 ug day-1
Justification: relatively new (Ursel et al. 2007) study, mean exposure to 8 phthalates in 5 consumer groups.
Organisation Date Media Value Units Description Reference Web link
IPCS Concise International
Chemical Assessment Documents
2000 Surface Water 1 ug day-1 In a compilation of concentrations (1984–1997) of
diethyl phthalate in North American and western
Staples CA, Parkerton TF, Peterson DR (2000) A risk assessment of selected
phthalate esters in North American and Western European surface waters.
http://inchem.org/documents/cicads/cicads/cicad52.htm
(CICADs)
European surface waters (USA, Canada, United Kingdom, Chemosphere , 40:885–891
Germany, Netherlands, Sweden), geometric mean
concentrations ranged from about 0.01 to 0.5 μg/litre
(Staples et al., 2000). Using the highest mean the
average daily intake through water consumption would
be 1 ug day (Using the CLEA calculation of 2 litres per
day intake)
2001 Food 0.35 ug day-1 In a duplicate-portion study, Tsumura et al. (2001) Tsumura Y, Ishimitsu S, Saito I, Sakai H, Kobayashi Y, Tonogai Y (2001) Eleven
estimated daily intake of 11 phthalate esters, including phthalate esters and di(2-ethylhexyl)adipate in one-week duplicate diet
diethyl phthalate and di(2-ethylhexyl) adipate, in 1-week samples obtained from hospitals and their estimates of daily intake. Food
total diet samples provided in hospitals. Portions of Additives and Contaminants , 18(5):449–460
meals of breakfast, lunch, and supper were obtained
from three hospitals located in three areas in Japan in
October or December 1999, for a period of 7 days.
Recovery of the spiked samples and quality assurance of
analysis were performed at three laboratories. Daily
intakes of diethyl phthalate were 0.07–1.41 μg/person
(samples in which diethyl phthalate was not detected
were assumed to contain diethyl phthalate at 50% of the
limit of detection, which was 0.1, 0.2, and 0.5 ng/g for
the three participating laboratories after subtraction of
the blank value). Average daily intakes in the three
hospitals were estimated to be 0.10, 0.28, and 0.67 μg
(overall average 0.35 μg) per day per person,
respectively
http://inchem.org/documents/cicads/cicads/cicad52.htm
US Agency for Toxic Substances
and Disease Registry (ATSDR)
Toxicological Profiles and
Minimal Risk Levels
1976 Drinking Water 0.2 ug day-1 Diethyl phthalate was found in the finished drinking Keith et al 1976. Identification of organic compounds in drinking water from
thirteen US cities.In:Keith LH,ed. Identification and analysis of organic
(Seattle, Washington; Philadelphia, Pennsylvania; New pollutants in water. Ann Arbor, M1: Ann Arbor Press, 329-373
York, New York) Based on this concentration the daily
intake is calculated to be 0.2 ug day, assuming 2 litres
intake a day.
1991 Food 4000 ug day-1 Estimated to be 4mg day based on a consumption of 1kg
of food wrapped in cellulose acetate containing diethyl
phthalate at a concentration of 4 mg/kg (Karmin and
Mayor, 1991)
Kamrin MA, Mayor GH. 1991. Diethyl Phthalate - a perspective. J Clin
Pharmacol 31(5):484-489
http://www.atsdr.cdc.gov/toxprofiles/tp73.html
http://www.atsdr.cdc.gov/toxprofiles/tp73.html
Entrez PubMed 2003 Total Intake 1547 ug day-1 A study on the German population found that the 95th
percentile of the population studied had an intake of
diethylphthalate of 22.1 ug/kg bw/day. The study used
excreted metabolites in urine to determine the intake
concentration of the individual.
Koch HM, Drexler H, Angerer J, (2003) An estimation of the daily intake of
di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general
population, International Journal Hyg Environmental Health. 2003
Mar;206(2):77-83
www.ncbi.nlm.nih.gov/entrez/query.fcgi
Other 2007 Total Intake 80.5 ug day-1
bodyweight day) in 5 consumer groups, mean and
maximal exposure – estimations based on ambient
monitoring and scenario calculations for uptake of food,
air, water, consumer products, household dust, leaching
from toys, etc. Adult mean daily intake of diethyl
phthalate was 1.15 ug/kg bw/day with the maximum
being 50.94. Using the 1.15 value a daily intake has
been calculated as 80.5 ug day
Ursel Heudorf, Volker Mersch-Sundermann and Jürgen Angerer (2007),
Phthalates: Toxicology and exposure International Journal of Hygiene and
Environmental Health Volume 210, Issue 5, 31 October 2007, Pages 623-634,
Children's Environment in Central Europe - Threats and Chances - Results of
an International Workshop held on November 21-24, 2006 in Osnabrück
http://www.sciencedirect.com/science_ob=ArticleURL&
_udi=B7GVY-4PPWMN9-
3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_d
ocanchor=&view=c&_acct=C000050221&_version=1&_url
Version=0&_userid=10&md5=24db0bb7c2fd9a3feb87b30f
3af5d14d
MAFF 1996 Food 100 - 800 ug day-1 MAFF Food Surveillance Information Sheet 82. Total Diet
Study identified between 0.1 to 0.8 mg/day exposure to
total phthalates within food
http://archive.food.gov.uk/maff/archive/food/infsheet/19
96/no82/82phthal.htm
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