Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Dichloromethane CAS 75-09-2 Assessor A: Nick Brown Grontmij Assessor B Catherine Helm WD Environmental Final Review Panel/SF<br />
Date 29/05/2009 Date 01/06/2009 Date 28/08/2009<br />
MDI<br />
Recommended<br />
MDIinhal<br />
Units<br />
350 ug day-1<br />
Justification: Based on the value provided by RIVM, converted assuming a 70kg adult.<br />
Organisation Date Media Value Units Description Reference Web link<br />
International Programme on 14/04/2009 As per WHO AQG <strong>for</strong> As per WHO AQG <strong>for</strong> As per WHO As per WHO AQG <strong>for</strong> Europe As per WHO AQG <strong>for</strong> Europe As per WHO AQG <strong>for</strong> Europe<br />
Chemical Safety (IPCS)<br />
Europe<br />
Europe<br />
AQG <strong>for</strong> Europe<br />
Joint Expert Committee on Food<br />
Additives (JECFA)<br />
WHO Guidelines <strong>for</strong> Drinking<br />
Water Quality<br />
WHO Air Quality Guidelines <strong>for</strong><br />
Europe<br />
14/04/2009 AS per WHO AS per WHO Guidelines AS per WHO<br />
Guidelines <strong>for</strong> DWQ <strong>for</strong> DWQ<br />
Guidelines <strong>for</strong><br />
14/04/2009 Urban Air 33-307 ug/day Estimated uptake from urban air Dichloromethane in Drinking Water. Background to the<br />
Development of WHO Guidelines <strong>for</strong> Drinking Water Quality.<br />
WHO 2003 (First Published 1996)<br />
14/04/2009 Indoor Air 16.3 ug/m3 National Pilot Study in Canadian Homes (757 homes) WHO Regional Office <strong>for</strong> Europe, Copenhagen, Denmark. 2000,<br />
Air Quality Guidelines 2nd Edition<br />
AS per WHO Guidelines <strong>for</strong> DWQ AS per WHO Guidelines <strong>for</strong> DWQ AS per WHO Guidelines <strong>for</strong> DWQ<br />
http://www.who.int/water_sanitation_health/dwq/chemi<br />
cals/dichloromethane.pdf<br />
http://www.euro.who.int/document/aiq/5_7dichlorometh<br />
ane.pdf<br />
Indoor Air 9.1 - 26.9 ug/m3 Small survey in Toronto. (Chan et al. 1990)<br />
Air 0.5 - 9.9 ug/m3 22 locations across Canada in 1991 - 1992 (Dann T, 1993)<br />
Air 0 - 570 ug/m3 20 cities across the US (Macalister R. et. Al. 1989)<br />
Air 1.8-3.1 ug/m3 Annual mean concentration at three sites within the San<br />
Francisco Bay Area over a four year period (Shiyaki et al<br />
1984)<br />
Dutch National Institute <strong>for</strong><br />
Public <strong>Health</strong> and the<br />
Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) Levels<br />
14/04/2009 Air 5 ug/kg-bw/day Estimated intake <strong>for</strong> the Netherlands is based on a<br />
Canadian study. Intake is expected to be primarily<br />
through inhalation indoors. 5ug/kg-bw/day is equivalent<br />
to 350ug/day <strong>for</strong> a 70kg adult<br />
RIVM Report 711701 025. Re-evaluation of human toxicological http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf<br />
maximum permissible risk levels A.J. Bars, R.M.C Theelan, P.J.C.M.<br />
Janssen, J.M. Hesse, M.E. van Apeldoorn, M.C.M. Meijerink,<br />
L.Verdam, M.J.Zeilmaker March 2001<br />
<strong>Health</strong> Canada Toxicological<br />
Values<br />
14/04/2009<br />
Air 0.5 - 9.9 ug/m3 22 locations across Canada in 1991 - 1992 Dann T, 1993<br />
Ambient Air 2.6 ug/m3 average from 17 urban sites across Canada Environment Canada, 1991<br />
Indoor Air 16.3 ug/m3 National Pilot Study in Canadian Homes (757 homes) Otson et al.1992<br />
http://www.hc-sc.gc.ca/ewh-<br />
semt/pubs/contaminants/psl1-<br />
lsp1/dichloromethane/dichloromethane_2-eng.php#a22<br />
US Agency <strong>for</strong> Toxic Substances<br />
and Disease Registry (ATSDR)<br />
Toxicological Profiles and<br />
Minimal <strong>Risk</strong> Levels<br />
14/04/2009<br />
Indoor Air 9.1 - 26.9 ug/m3 Small survey in Toronto. Chan et al. 1990<br />
Background<br />
0.17 ug/m3 No detail of study. (Singh et al. 1982)<br />
Toxicological Profile <strong>for</strong> Methylene Chloride. ATSDR, September<br />
concentration in air<br />
2000<br />
Outdoor air 0.61 - 1.62 ug/m3 Range of concentrations recorded in Arizona. Maximum<br />
recorded in urban Phoenix (Zielinski et al. 1998)<br />
http://www.atsdr.cdc.gov/toxprofiles/tp14-c5.pdf<br />
Toxicological Data Network<br />
(TOXNET)<br />
14/04/2009<br />
Concentrations likely to be higher in indoor air<br />
Outdoor air 0.5 ug/m3 A mean concentration detected in 2966 air samples<br />
collected from 78 sites in populated areas of the US<br />
Kelly TJ et al; Environ Sci Technol 28: 378A-387A (1994)<br />
http://toxnet.nlm.nih.gov/cgibin/sis/search/f./temp/~VTz5nQ:1<br />
Indoor Air<br />
170 ug/m3 Dichloromethane was detected in 41 of 101 indoor air<br />
samples collected from several dwellings in several<br />
countries between 1978 and 1990. AVG max<br />
concentration of 170ug/m3<br />
2.6 - 119.7 ug/m3<br />
DCM recorded in a new federal office building in<br />
Portland, Oregon between August 1987 and October<br />
1988 at concns ranging from 2.6 to 119.7 ug/cu m<br />
Brown SK et al; Indoor Air 4:123-34 (1994)<br />
Hodgson AT et al; Air Waste Manag Assoc 41: 1461-68 (1991)<br />
Page 2 of 2 EIC Pro<strong>for</strong>ma dichloromethane.xls 28/08/2009
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