Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Dichloromethane CAS 75-09-2 Assessor A: Nick Brown Grontmij Assessor B Catherine Helm WD Environmental Final Review Panel/SF
Date 29/05/2009 Date 01/06/2009 Date 28/08/2009
MDI
Recommended
MDIoral
Units
88.118 ug day-1
Justification: Conservative value of the sum of DCM in US food (95 μg/kg maximum) (Health Canada) and US bottled drinking water (0.059 ppb) (ATSDR) used. Food concentration
converted to an intake of 88 ug/d by assuming that an adult eats on average 0.93 kg of food per day (from FSA, "Measurement of the Concentrations of Metals and Other Elements
from the 2006 UK Total Diet Study", January 2009). Water concentration converted to an intake of 0.118 ug/d by assuming that an adult drinks 2 L of water per day (i.e. negligible in
comparison to food intake). Thus, total MDIoral equal to approximately 95 ug/d
Organisation Date Media Value Units Description Reference Web link
International Programme on
Chemical Safety (IPCS)
14/04/2009 Low in food & water 0 www.who.int/ipcs/en
14/04/2009 As per WHO As per WHO Guidelines As per WHO As per WHO Guidelines for DWQ
As per WHO Guidelines for DWQ
As per WHO Guidelines for DWQ
Guidelines for DWQ for DWQ
Guidelines for
Joint Expert Committee on Food
DWQ
Additives (JECFA)
WHO Guidelines for Drinking
Water Quality
14/04/2009 Food and drinking
water
0 NA Estimated uptake from food and drinking water expected
to be insignificant
Dichloromethane in Drinking Water. Background to the
Development of WHO Guidelines for Drinking Water Quality.
WHO 2003 (First Published 1996)
http://www.who.int/water_sanitation_health/dwq/chemi
cals/dichloromethane.pdf
Dutch National Institute for
Public Health and the
Environment (RIVM) Maximum
Permissible Risk (MPR) Levels
14/04/2009 Food and drinking
water
0 ug/kg-bw/day Intake via food and water in the Netherlands is assumed
to be negligible
RIVM Report 711701 025. Re-evaluation of human toxicological http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf
maximum permissible risk levels A.J. Bars, R.M.C Theelan, P.J.C.M.
Janssen, J.M. Hesse, M.E. van Apeldoorn, M.C.M. Meijerink,
L.Verdam, M.J.Zeilmaker March 2001
Health Canada Toxicological
Values
14/04/2009 Food types 19 - 95 (concentration
in specific food types)
ug/kg
Data on levels of dichloromethane in foods in Canada
are very limited. However DCM concentrations
monitored by the Total Diet Program of the U.S. Food
and Drug Administration . Levels in ready-to-eat cereals
and butter were the highest (95 and 84 μg/kg,
respectively), followed by cheese (45 μg/kg), margarine
(27 μg/kg), processed foods (34 μg/kg), and peanut
butter (19 μg/kg).
Heikes and Hopper, 1986; Heikes, 1987a, 1987b; Draft, 1988
http://www.hc-sc.gc.ca/ewh-
semt/pubs/contaminants/psl1-
lsp1/dichloromethane/dichloromethane_2-eng.php#a22
US Agency for Toxic Substances
and Disease Registry (ATSDR)
Toxicological Profiles and
Minimal Risk Levels
14/04/2009
Drinking water