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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Dichloromethane ID inhal Organisation Study type Description Response Reference Web link Health Canada Toxicological Values Mice Bioassay (NTP 1996) Multi stage modelling of the incidence Pulmonary adenomas and carcinomas of cancer undertaken using data from NTP study (NTP 1996). Clear evidence of increased incidence of lung tumors in female mice identified at 13,880mg/m3. NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies). NTP-TRS-306. http://www.hc-sc.gc.ca/ewh-semt/pubs/contaminants/psl1- lsp1/dichloromethane/ USEPA Integrated Risk Information System (IRIS) F344/N rats and B6C3F1 mice Groups of 50 each male and female rats Mammary adenomas, fibroadenomas and and mice were exposed to mononuclear cell leukaemia in female rats. dichloromethane by inhalation, 6 Hepatocellular adenomas and carcinomas hours/day, 5 days/week for 2 years . and alveobronchiolar adenomas and Exposure concentrations were 0, 1000, acrcinomas in mice 2000, or 4000 ppm for rats and 0, 2000, or 4000 ppm for mice. Increased occurrence of cancer in mice and female rats was demonstrated. NTP (National Toxicology Program). 1986. Toxicology and carcinogenesis studies of dichloromethane (methylene chloride) (CAS No. 75-09-2) in F344/N rats and B6C3F1 mice (inhalation studies). NTP-TRS-306. TOXNET 2 See Health Canada See Health Canada See Health Canada http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~ic5Vi3:1 http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~9nJJZL:1 Page 6 of 6 EIC Proforma dichloromethane.xls 28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Dichloromethane CAS 75-09-2 Assessor A: Nick Brown Grontmij Assessor B Catherine Helm WD Environmental Final Review Panel/SF Date 29/05/2009 Date 01/06/2009 Date 28/08/2009 MDI Recommended MDIoral Units 88.118 ug day-1 Justification: Conservative value of the sum of DCM in US food (95 μg/kg maximum) (Health Canada) and US bottled drinking water (0.059 ppb) (ATSDR) used. Food concentration converted to an intake of 88 ug/d by assuming that an adult eats on average 0.93 kg of food per day (from FSA, "Measurement of the Concentrations of Metals and Other Elements from the 2006 UK Total Diet Study", January 2009). Water concentration converted to an intake of 0.118 ug/d by assuming that an adult drinks 2 L of water per day (i.e. negligible in comparison to food intake). Thus, total MDIoral equal to approximately 95 ug/d Organisation Date Media Value Units Description Reference Web link International Programme on Chemical Safety (IPCS) 14/04/2009 Low in food & water 0 www.who.int/ipcs/en 14/04/2009 As per WHO As per WHO Guidelines As per WHO As per WHO Guidelines for DWQ As per WHO Guidelines for DWQ As per WHO Guidelines for DWQ Guidelines for DWQ for DWQ Guidelines for Joint Expert Committee on Food DWQ Additives (JECFA) WHO Guidelines for Drinking Water Quality 14/04/2009 Food and drinking water 0 NA Estimated uptake from food and drinking water expected to be insignificant Dichloromethane in Drinking Water. Background to the Development of WHO Guidelines for Drinking Water Quality. WHO 2003 (First Published 1996) http://www.who.int/water_sanitation_health/dwq/chemi cals/dichloromethane.pdf Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) Levels 14/04/2009 Food and drinking water 0 ug/kg-bw/day Intake via food and water in the Netherlands is assumed to be negligible RIVM Report 711701 025. Re-evaluation of human toxicological http://www.rivm.nl/bibliotheek/rapporten/711701025.pdf maximum permissible risk levels A.J. Bars, R.M.C Theelan, P.J.C.M. Janssen, J.M. Hesse, M.E. van Apeldoorn, M.C.M. Meijerink, L.Verdam, M.J.Zeilmaker March 2001 Health Canada Toxicological Values 14/04/2009 Food types 19 - 95 (concentration in specific food types) ug/kg Data on levels of dichloromethane in foods in Canada are very limited. However DCM concentrations monitored by the Total Diet Program of the U.S. Food and Drug Administration . Levels in ready-to-eat cereals and butter were the highest (95 and 84 μg/kg, respectively), followed by cheese (45 μg/kg), margarine (27 μg/kg), processed foods (34 μg/kg), and peanut butter (19 μg/kg). Heikes and Hopper, 1986; Heikes, 1987a, 1987b; Draft, 1988 http://www.hc-sc.gc.ca/ewh- semt/pubs/contaminants/psl1- lsp1/dichloromethane/dichloromethane_2-eng.php#a22 US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk Levels 14/04/2009 Drinking water
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