Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Dichloromethane CAS Number: 75-09-2
Assessor A: Nick Brown, Grontmij Assessor B Catherine Helm, WD Final Review:
Panel/SF
Environmental
Date 26/05/2009 Date 01-Jun-09 Date 28/08/2009
Oral
Dermal
Inhalation
Combine Oral and
Inhalation TDIs
Justification
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Yes Yes No
No No No
Human studies are considered generally inadequate to
demonstrate whether or not DCM is carcinogenic. See detailed
discussion below regarding selection of threshold behaviour for
dichloromethane. TDIoral applied to oral and dermal routes.
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
No No Yes
No No No
Yes
Human studies are considered generally inadequate to
demonstrate whether or not DCM is carcinogenic. See detailed
discussion below regarding selection of threshold behaviour for
dichloromethane. TDIinh applied to inhalation route
TDI oral Recommended TDIoral Units
6 ug.kg-1.d-1
Justification
Based on NCA 1982 study, cited by WHO DW, IPCS, JECFA.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-1.d-1 Confidence rating Basis Value Units UF UF description
Health and Safety Laboratory (HSL) http://www.hsl.gov.uk/ 02/04/2009 8-hour time weighted
average
International Programme on Chemical Safety
(IPCS)
100 ppm (1ppm = 3.5
mg/m3)
http://www.who.int/ipcs/en/ Data reviewed 2003 14/04/2009 DW guideline 6 ug/kg/day 6 NOAEL 6 mg/kg bw/day 1000 100 for intra and inter
species variation and
10 for concern about
carcinogenic potential
100000
Joint Expert Committee on Food Additives
(JECFA)
http://who.int/ipcs/food/jecfa/en/ Published 2003 05/05/2009 TDI oral 6 ug/kg/day 6 NOAEL 6 mg/kg bw/day 1000 100 for intra and inter
species variation and
10 reflecting concern
about carcinogenic
potential
WHO Guidelines for drinking water Quality
http://www.who.int/water_sanitation_health
/dwq/guidelines/en
02/04/2009 TDI oral 6 ug/kg/day 6 NOAEL 6 mg/kg bw/day 1000 100 for intra and inter
species variation and
10 reflecting potential
for carcinogenic
potential
Dutch National Institute for Public Health and http://www.rivm.nl/en/ Published 2001 60 ug/kg/day 60
the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/ 01/04/2009 MRL 60 ug/kg/day 60 NOAEL 6 mg/kg bw/day 100 x 10 interspecies and x
10 intraspecies
USEPA Acute Guideline Levels (AEGLs) http://epa.gov/oppt/aegl/pubs/chemlist.htm 13/11/2009 14/04/2009 AEGLs 60 & 2100 ppm (1ppm = 3.5 60000 and 2100000
mg/m3)
USEPA Health Advisors
http://www.epa.gov/waterscience/criteria/dri
nking
Summer 2006 14/04/2009 MCL 0.005 mg/l 0.14
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 02/04/2009 RfD 60 ug/kg/day 60 High confidence in NOAEL
study. Medium
Confidence in RfD
100 x 10 interspecies and x
10 intraspecies
Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ 28/04/2009 See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above
Page 1 of 6 EIC Proforma dichloromethane.xls 28/08/2009