Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Substance: Cis 1,2 Dichloroethene CAS Number: 156-59-2 Assessor A: Claire Potter Assessor B: Catherine Helm Final Review Panel/SF Chemical Formula: C2H2Cl2 Phase at Ambient Liquid Tempertaure Date: 01-Apr-09 Date: 29/05/2009 Date: 28/08/2009 http://srdata.nist.gov/solubility/ http://webbook.nist.gov/chemistry/ http://cs3-hq.oecd.org/scripts/hpv/ A B C D E F G H Property Units Calculated Value Adopted Value Ref. Temp (C) Rationale References HOWARD, 1990 LIDE, 2008 MACKAY et al, 2006 MERCK, 2006 MONTGOMERY, 2007 MONTGOMERY, 1997 NIST, 2005 OECD, 2000 Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Source Units SR7 Units Ref. Temp (C) Required Parameters Relative Molecular Mass g mol -1 n/a 96.94 n/a g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) g mol -1 g mol -1 Ref. Temp (C) Median value from consistent Average 96.94 n/a 96.943 n/a 96.943 n/a 96.94 n/a 96.94 n/a Insert Values n/a 96.9427 n/a Insert Values n/a range of literature values 96.94 96.94 n/a 96.943 96.943 n/a 96.943 96.943 n/a 96.94 96.94 n/a 96.94 96.94 n/a n/a 96.9427 96.9427 n/a n/a Henry's Law Constant (HLC) Solubility (S) 10 oC where possible. (Use unit converter if source provides different units) Pa m3 mol-1 mg/L n/a n/a 4.60E+02 7.55E+03 25 10 Adopted value is that from the newest source (Lide 2008) as there is no consistent range Median of three literature values which show consistent range at 10 degrees atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) KPa m3 mol-1 Pa m3 mol-1 Ref. Temp (C) Pa m3 mol-1 Pa m3 mol-1 Ref. Temp (C) n/a n/a n/a atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) mol kg-1 bar-1 Pa m3 mol-1 Ref. Temp (C) atm m3 mol-1 Pa m3 mol-1 Ref. Temp (C) Geomean 3.41E+02 25 4.60E+02 25 5.56E+02 25 9.21E+02 25 Insert Values 25 4.09E+02 25 Insert Values 25 3.37E-03 3.41E+02 4.60E-01 4.60E+02 3.42E+02 342.2 9.09E-03 921.04425 2.40E-01 4.18E+02 745.5 745.5 0.26 3.86E+02 674.5 674.5 0.24 4.18E+02 25 25 Two calculated values not included (1970 and 2370) n/a n/a n/a 25 0.23 4.36E+02 0.25 4.01E+02 0.21 4.78E+02 0.27 3.71E+02 0.22 4.56E+02 0.3 3.34E+02 mg/L mg/L Ref. Temp (C) g/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) mg/L mg/L Ref. Temp (C) Geomean 3.50E+03 7.60E+03 10 4.27E+03 25 Insert Values 6.28E+03 25 Insert Values 7.55E+03 10 Insert Values 3.50E+03 3.50E+03 7.60E+00 7600 3.52E+03 3.52E+03 6.26E+03 6.26E+03 7.55E+03 7.55E+03 3500 3.50E+03 6300 6.30E+03 3500 3.50E+03 7700 7.70E+03 No reference 7,550 mg/l at temperature 10oC provided 25 12 values provided, only 9 included as 3 were stated to be 0.13 one of which is was unclear how value had been obtained 25 Chemical Boiling Point (ambient pressure) K n/a 3.33E+02 n/a Median value from consistent range of literature values o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) K K Ref. Temp (C) o C K Ref. Temp (C) Average 3.33E+02 n/a 3.33E+02 n/a 3.33E+02 n/a 3.33E+02 n/a 3.21E+02 n/a Insert Values n/a 3.33E+02 n/a Insert Values n/a 60.3 333.45 n/a 60.1 333.25 n/a 60.1 333.25 n/a 59.6 332.75 n/a 47.5 320.65 n/a n/a 333.34 333.34 n/a n/a n/a n/a n/a 60 333.15 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) o C K Ref. Temp (C) K K Ref. Temp (C) o C K Ref. Temp (C) Chemical Melting Point (ambient pressure) Log Octanol - Water Coefficient Molar Volume (Le Bas method) Enthalpy of Vaporisation at normal boiling point (EVNBP) K Dimensionless cm3 mol-1 J Mol-1 n/a n/a n/a 29732.73616 1.93E+02 1.86 8.62E+01 2.97E+04 n/a n/a n/a Normal Chemical Boiling Point Median value from consistent range of values Median value from consistent range of values Single available value Calculated Value Average 1.93E+02 n/a 1.93E+02 n/a 1.93E+02 n/a 1.92E+02 n/a removed value Insert Values n/a 1.93E+02 n/a Insert Values n/a -80.5 192.65 n/a -80 193.15 n/a -80 193.15 n/a -81.5 191.65 n/a -50 223.15 from median as n/a 193 193.00 n/a n/a n/a n/a n/a n/a sig higher than the n/a n/a n/a n/a n/a n/a n/a other 5 n/a n/a n/a Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Dimensionless Dimensionless Ref. Temp (C) Average 1.86E+00 n/a 1.86E+00 n/a 1.86E+00 n/a Insert Values n/a 2.08E+00 n/a Insert Values n/a Insert Values n/a Insert Values n/a 1.86 1.86 n/a 1.86 1.86 n/a 1.86 1.86 n/a n/a 2.06 2.06 n/a n/a n/a n/a n/a n/a 1.86 1.86 n/a n/a 2.09 2.09 n/a n/a n/a n/a n/a n/a 1.85 1.85 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a cm3 mol-1 cm3 mol-1 Ref. Temp (C) Average n/a n/a n/a n/a n/a n/a 8.62E+01 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a 86.2 86.20 n/a KJ mol-1 J Mol-1 KJ mol-1 J Mol-1 KJ mol-1 J Mol-1 Ref. Temp (C) Average 3.02E+04 3.09E+04 3.10E+04 n/a n/a n/a 30.2 30200 31.57 31570 29 29000 n/a n/a n/a n/a n/a n/a n/a n/a n/a Normal Boiling 30.23 30230 Normal Boiling 33 33000 Normal Boiling n/a n/a n/a Point Point 30.9 30900 Point Chemical Critical Point temperature (ambient pressure) K 526.8153773 5.27E+02 n/a Calculated Value K K Ref. Temp (C) o C K Ref. Temp (C) K K Ref. Temp (C) o C K Ref. Temp (C) Average 5.44E+02 n/a Insert Values n/a Insert Values n/a Insert Values n/a n/a n/a n/a 544.2 544.20 n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Bar Atmosph Ref. Temp (C) Bar Atmosph Ref. Temp (C) Average Insert Values Insert Values Critical Pressure atm 51.19955043 51.20 Calculated Value n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a n/a Calcuated parameters for input to CLEA model (UPDATED FROM THE SPREADSHEET TOOL) Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Property Units Calculated Value Ref. Temp (C) Rationale Air-water partition coefficient at ambient soil temperature cm 3 .cm -3 7.461E-02 10 Estimated from parameters above using Clapyron relationship or direct calculation Vapour pressure at ambient soil temperature Pa 13685.6591 10 Estimated from parameters above using Grain-Watson method Diffusion coefficient in air m 2 .s -1 9.02E-06 10 Estimated from parameters above using Wilkie-Lee method Diffusion coefficient in water m 2 .s -1 7.08E-10 10 Estimated from parameters above using Hayduk and Laudie method Organic carbonwater partition coefficient Log cm 3 .g -1 1.61 n/a Estimated from parameters above using equation in Table 2.12 of SR7 Page 3 of 3 EIC Proforma cis 1,2 dichloroethene.xls28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Dichloromethane CAS Number: 75-09-2 Assessor A: Nick Brown, Grontmij Assessor B Catherine Helm, WD Final Review: Panel/SF Environmental Date 26/05/2009 Date 01-Jun-09 Date 28/08/2009 Oral Dermal Inhalation Combine Oral and Inhalation TDIs Justification Apply TDIoral to exposure routes Apply IDoral to exposure routes Yes Yes No No No No Human studies are considered generally inadequate to demonstrate whether or not DCM is carcinogenic. See detailed discussion below regarding selection of threshold behaviour for dichloromethane. TDIoral applied to oral and dermal routes. Apply TDIinh to exposure routes Apply IDinh to exposure routes No No Yes No No No Yes Human studies are considered generally inadequate to demonstrate whether or not DCM is carcinogenic. See detailed discussion below regarding selection of threshold behaviour for dichloromethane. TDIinh applied to inhalation route TDI oral Recommended TDIoral Units 6 ug.kg-1.d-1 Justification Based on NCA 1982 study, cited by WHO DW, IPCS, JECFA. Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-1.d-1 Confidence rating Basis Value Units UF UF description Health and Safety Laboratory (HSL) http://www.hsl.gov.uk/ 02/04/2009 8-hour time weighted average International Programme on Chemical Safety (IPCS) 100 ppm (1ppm = 3.5 mg/m3) http://www.who.int/ipcs/en/ Data reviewed 2003 14/04/2009 DW guideline 6 ug/kg/day 6 NOAEL 6 mg/kg bw/day 1000 100 for intra and inter species variation and 10 for concern about carcinogenic potential 100000 Joint Expert Committee on Food Additives (JECFA) http://who.int/ipcs/food/jecfa/en/ Published 2003 05/05/2009 TDI oral 6 ug/kg/day 6 NOAEL 6 mg/kg bw/day 1000 100 for intra and inter species variation and 10 reflecting concern about carcinogenic potential WHO Guidelines for drinking water Quality http://www.who.int/water_sanitation_health /dwq/guidelines/en 02/04/2009 TDI oral 6 ug/kg/day 6 NOAEL 6 mg/kg bw/day 1000 100 for intra and inter species variation and 10 reflecting potential for carcinogenic potential Dutch National Institute for Public Health and http://www.rivm.nl/en/ Published 2001 60 ug/kg/day 60 the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels http://www.atsdr.cdc.gov/ 01/04/2009 MRL 60 ug/kg/day 60 NOAEL 6 mg/kg bw/day 100 x 10 interspecies and x 10 intraspecies USEPA Acute Guideline Levels (AEGLs) http://epa.gov/oppt/aegl/pubs/chemlist.htm 13/11/2009 14/04/2009 AEGLs 60 & 2100 ppm (1ppm = 3.5 60000 and 2100000 mg/m3) USEPA Health Advisors http://www.epa.gov/waterscience/criteria/dri nking Summer 2006 14/04/2009 MCL 0.005 mg/l 0.14 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 02/04/2009 RfD 60 ug/kg/day 60 High confidence in NOAEL study. Medium Confidence in RfD 100 x 10 interspecies and x 10 intraspecies Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ 28/04/2009 See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above See IRIS above Page 1 of 6 EIC Proforma dichloromethane.xls 28/08/2009
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