Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Cis 1,2 Dichloroethene
CAS Number: 156-59-2 Assessor A:
Nick Brown,
Grontmij
Assessor B:
Catherine Helm,
WD
Environmental
Final Review:
Panel/SF
Date 26/05/2009 Date 29/05/2009 Date 28/08/2009
Apply TDIoral to Exposure Routes
Apply IDoral to Exposure Routes
Oral Dermal Inhalation Combine Oral and
Inhalation TDIs
Yes Yes Yes
No No No
Justification
EPA classifies Cis 1,2 Dichloroethene as D - not
classifiable as to human carcinogenicity.
Carcinogenicity data is generally absent. TDIoral
applied to oral and dermal routes
Apply TDIinh to Exposure Routes
Apply IDinhal to Exposure Routes
No No No
No No No
NR
EPA classifies Cis 1,2 Dichloroethene as D - not
classifiable as to human carcinogenicity.
Carcinogenicity data is generally absent. Insufficient
data with sufficient detail on derivation to derive
TDIinhal. Use route-to-route extrapolation from oral.
TDI oral
Recommended
TDIoral
Units
6 ug/kg/day
Justification
RIVM health criterion selected as this is conservative and chemical specific (IPCS/JECFA is based on trans-isomer).
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence
1.d-1
rating
International Programme on Chemical Safety
(IPCS)
http://www.who.int/ipcs/en/ Published 2003 29/04/2009 TDI 17 ug/kg bw/day 17 NOAEL for trans
isomer
Basis Value Units UF UF description
17 mg/kg-bw-day 1000 10 each for inter- and intraspecies
variation, 10 for limited study duration
Joint Expert Committee on Food Additives (JECFA) http://who.int/ipcs/food/jecfa/en/ Published 2003 29/04/2009 TDI 17 ug/kg bw/day 17 NOAEL for trans
isomer
17 mg/kg-bw-day 1000 10 each for inter- and intraspecies
variation, 10 for limited study duration
Dutch National Institute for Public Health and the
Environment (RIVM) Maximum Permissible Risk
(MPR) levels
http://www.rivm.nl/en/ Published 2001 29/04/2009 TDI Oral 6 ug/kg bw/day 6 Medium
Reliability
NOAEL 32 mg/kg-bw/day 5000 10 each for inter- and intraspecies
variation, 10 for limited study duration, and
5 for severity of endpoint
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/ Re-published 2008 29/04/2009 Oral Minimum Risk
Level (int)
0.3 mg/kg bw/day 300 NOAEL 32 mg/kg-bw/day 100 x10 for inter- and x 10 for intraspecies
variation
USEPA Acute Guideline Levels (AEGLs) http://epa.gov/oppt/aegl/pubs/chemlist.htm 02/04/2009 8-hour AEGLs 140, 230, 310 ppm 158, 259.6, 349.9
US EPA Provisional Peer Reviewed Toxicity Values
(PPRTV)
http://rais.ornl.gov/tox/unauthorized.shtml Published 2006 Chronic RfD 0.01 mg/kg bw/day 10 Low NOAEL 32 mg/kg-bw/day 3000 10 each for inter- and intraspecies
variation, 10 for limited study duration, and
3 for database limitations including lack of
reproductive or developmental studies
TDI inhalation
Recommended
TDIinhal
Units
ug/kg/day
Justification
Insufficient data with sufficient detail on derivation to derive. Use route-to-route extrapolation from oral. RIVM 'route to route extrapolation' method is unclear, value is o
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence
1.d-1
rating
Dutch National Institute for Public Health and the
Environment (RIVM) Maximum Permissible Risk
(MPR) levels
http://www.rivm.nl/en/ Published 2001 29/04/2009 Preliminary TCA
(tolerable concentration
in air)
30 ug/m3 8.57 Low Reliability Route to route
extrapolation from
the oral TDI
Basis Value Units UF UF description
5000 10 each for inter- and intraspecies
variation, 10 for limited study duration, and
5 for severity of endpoint
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EIC Proforma cis 1,2 dichloroethene.xls28/08/2009