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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloromethane / Methyl Chloride USEPA Integrated Risk Information System (IRIS) Mouse Intermediate 11 Day Mouse inhalation study cerebellar lesions IRIS Database - Landry et al., 1983, 1985 http://www.epa.gov/NCEA/iris/subst/1003.htm http://www.epa.gov/ncea/iris/toxreviews/1003-tr.pdf ID oral Organisation to its human carcinogenicity (2001). Study type Description Response Reference Web link International Agency for Research on Cancer (IARC) Methyl Chloride is not classifiable as to its carcinogenicity to humans (Group 3) International Agency for Research on Cancer (IARC) - Summaries & Evaluations. Vol 71. (1999) p. 737. http://www.inchem.org/documents/iarc/vol71/026-methylchloride.html USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/iris/subst/1003.htm ID inhal to its human carcinogenicity (2001). Organisation Study type Description Response Reference Web link International Agency for Research on Cancer (IARC) Methyl Chloride is not classifiable as to its carcinogenicity to humans (Group 3) International Agency for Research on Cancer (IARC) - Summaries & Evaluations. Vol 71. (1999) p. 737. http://www.inchem.org/documents/iarc/vol71/026-methylchloride.html USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/iris/subst/1003.htm Page 4 of 4 EIC proforma chloromethane 09/09/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloromethane CAS 74-87-3 Assessor A: A. Fellows Assessor B: S. Cole Final review: Panel/SF Date 28/05/2009 Date 26.06.2009 Date 09/09/2009 MDI Recommend ed MDIoral Units 0 ug day-1 Justification: No suitable data on likley average exposure. Chloromethane exists primarily as a gas, therefore reasonable to assume background oral concentration is negligible. Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents 22/06/1905 Surface Water - River Rhine (CICADs) IPCS Concise International Chemical Assessment Documents (CICADs) Organisation for the Economic Co-operation and Development (OECD) Screening Information Data Set (SIDS) for High Production Volume Chemicals 12 ug/l maximum concentration in surface waters of Europe - River Rhine Concise International Chemical Assessment Document 28. page 10 22/06/1905 Drinking water well 44 ug/l maximum concentration of Concise International drinking water well Chemical in USA Assessment Document 28. page 10 22/10/2002 water 0.222 ug/l Observed at low concentrations in water (No reference stated) SIDS Initial Assessment Profile. (SIAM 15) http://inchem.org/p ages/cicads.html http://inchem.org/p ages/cicads.html http://inchem.org/p ages/sids.html MDI Recommend ed MDIinh Units 212 ug day-1 Justification: Average urban concentration from all reported values (IPCS CICAD data). Adjusted for CLEA adult inhalation assuming inhalation of 20m3/day. Organisation Date Media Value Units Description Reference Web link IPCS Concise International Chemical Assessment Documents (CICADs) 2000 outdoor air concentrations in urban environments 10.62 ug/m3 Measured Air concentrations in urban/suburban USA, three Japanese cities, Delft (Netherlands) and Lisbon (Portugal). Concise International Chemical Assessment Document 28. page 9 http://inchem.org/p ages/cicads.html Organisation for the Economic Co-operation and Development (OECD) Screening Information Data Set (SIDS) for High Production Volume Chemicals 22/10/2002 ambient air 700 ppt Natural levels of Chloromethane in ambient air SIDS Initial Assessment Profile. (SIAM 15) http://inchem.org/p ages/sids.html Page 1 of 1 EIC proforma chloromethane 09/09/2009
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