Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloromethane / Methyl Chloride TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link European Chemicals Bureau (ECB) USEPA Health Advisors unknown Compilation Table 2006 drinking water standards and health advisories. Stated Reference Dose for Oral consumption of water. RfD quoted from IRIS in report. unknown Drinking water standards. Page 8 in source. http://www.epa.gov/waterscience/criteria/drinking/dwstandards.pdf USEPA Integrated Risk Information System (IRIS) http://www.epa.gov/iris/subst/1003.htm TDI inhal Organisation Study type Description Response Reference Web link IPCS concise International Chemical Assessment Documents (CICADs) Fischer 344 Rats and B6C3F1 Mice Chronic Two year inhalation study of rats and mice. (CIIT, 1981). 103mg/m3 LOAEL converted for continuous exposure to 18 mg/m3. (0.0018 mg/m3 reported as guidance value for indirect exposure via environment) Exposure at LOAEL of 103 mg/m3 (50 ppm) induced Axonal swelling and degeneration of spinal nerves. Also supported by renal microcysts in 103 mg/m3 group Chemical Industry Institute of Toxicology. Final report on a chronic inhalation toxicology study in rats and mice exposed to methyl chloride. Unpublished study prepared by Battelle- Columbus Laboratories, Columbus, OH. OTS Submission Document ID 40-8120717. Microfiche No. 511310. (1981). http://www.inchem.org/documents/cicads/cicads/cicad28.htm Organisation for Economic Co-operation and Development (OECD) Screening Information Data Set (SIDS) for High Production Volume Chemicals Fischer 344 Rats and B6C3F1 Mice Chronic Two year inhalation bioassay rats and mice exposed to 100, 450, 2000 mg/m3. Exposure at LOAEL of 2000 mg/m3 increased heart weights, kidney and liver weights in rats. Severe effects were seen in mice at the LOAEL. SIDS Initial Assessment Report for SIAM 15 (Boston, USA, October 2002) http://www.inchem.org/documents/sids/sids/CLMETHANE.pdf US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels Mouse B6C3F1 Chronic 18 month inhalation study used in derivation of inhalation MRL axonal swelling and slight degeneration of axons in spinal cord. Toxicological profile for chloromethane December 1998 Section 2 and section 7. From study by CIIT 1981 http://www.atsdr.cdc.gov/toxprofiles/tp106.html Page 2 of 4 EIC proforma chloromethane 09/09/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloromethane / Methyl Chloride CAS Number: 74-87-3 Assessor A: A. Fellows Assessor B: S. Cole Final review: Panel/SF Date 28.05.2009 Date 26.06.2009 Date 09/09/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ Study 1983, 1985 (Last revised on website 17/07/2001) 26/05/2009 RfC 0.09 mg/m 3 25.71 Medium NOAEL 94.6 mg / m3 1000 A factor of 3 for interspecies extrapolation, 10 for extrapolation from an 11 day study to a lifetime study and a factor of 10 for intraspecies variability and lack of brain histopathology in F1 mice. Because two factors of 3 (101/2) coalesce to a 10, the total uncertainty factor applied to NOAEL the of 94.6 mg/m3 is 1,000 ID oral Recommended IDoral n/a Units Justification IARC classification: Group 3, insufficient evidence for the carcinogenicity of methyl chloride to humans, 1999. IRIS classification: Group D, not classifiable as t Organisation Web Link Last Updated Date Web Checked Non threshold effects International Agency for Research on http://inchem.org/pages/iarc.html 13/04/1999 27/05/2009 Cancer (IARC) Basis Health criteria type Value Units Confidence rating Basis "There is inadequate evidence for the carcinogenicity of Methyl Chloride to humans." USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 07/17/2001 28-May-09 Data for carcinogenicity in humans is considered inadequate. methyl chloride is most appropriately designated a Group D - Not classifiable as to its human carcinogenicity. ID inhal Recommended IDinhal n/a Units Justification IARC classification: Group 3, insufficient evidence for the carcinogenicity of methyl chloride to humans, 1999. IRIS classification: Group D, not classifiable as t Organisation Web Link Last Updated Date Web Checked Non threshold effects International Agency for Research on http://inchem.org/pages/iarc.html 13/04/1999 27/05/2009 Cancer (IARC) Basis Health criteria type Value Units Confidence rating Basis "There is inadequate evidence for the carcinogenicity of Methyl Chloride to humans." USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 07/17/2001 28-May-09 Data for carcinogenicity in humans is considered inadequate. methyl chloride is most appropriately designated a Group D - Not classifiable as to its human carcinogenicity. Page 3 of 4 EIC proforma chloromethane 09/09/2009
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