Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Chloromethane / Methyl Chloride CAS Number: 74-87-3 Assessor A: A. Fellows Assessor B: S. Cole Final review: Panel/SF<br />
Date 28.05.2009 Date 26.06.2009 Date 09/09/2009<br />
Oral<br />
Dermal<br />
Inhalation<br />
Combine Oral<br />
and Inhalation<br />
TDIs<br />
Justification<br />
Apply TDIoral to exposure routes<br />
Apply IDoral to exposure routes<br />
No No No<br />
No No No<br />
NR<br />
Group 3 carcinogen (IARC), no strong evidence to be<br />
a human carcinogen - Insufficient data to derive<br />
TDIoral<br />
Apply TDIinh to exposure routes<br />
Apply IDinh to exposure routes<br />
Yes Yes Yes<br />
No No No<br />
Group 3 carcinogen (IARC), no strong evidence to be<br />
a human carcinogen- TDIinh applied to orla, dermal<br />
and inhal routes<br />
TDI oral<br />
Recommended<br />
TDIoral<br />
Units<br />
ug.kg-1.d-1<br />
Justification<br />
Insufficient data with required supporting data to derive a TDIinhal (USEPA <strong>Health</strong> Advisors RfD based on IRIS RfD which has subsequently been withdrawn)<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description<br />
1.d-1<br />
European Chemicals Bureau (ECB) http://ecb.jrc.it/ 19/02/2000 27/05/2009 Data In German<br />
USEPA <strong>Health</strong> Advisors<br />
http://www.epa.gov/waterscience/criteria/d<br />
rinking<br />
Published drinking<br />
water health<br />
advisory August<br />
2006, based on<br />
chloromethane<br />
report 1989<br />
28/05/2009 RfD 0.004 mg /kg/day 4 Unknown 0.004 mg kg day unknown unknown<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
http://epa.gov/iris/ July 2001 28/05/2009 Methyl chloride<br />
exists primarily as a<br />
gas. No adequate<br />
oral exposure studies<br />
exist from which an<br />
oral RfD may be<br />
derived.<br />
TDI inhal<br />
Recommended<br />
TDIinhal<br />
Units<br />
5.14 ug.kg-1.d-1<br />
Justification<br />
CICADs TDI used as this is most conservative<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description<br />
1.d-1<br />
IPCS concise International Chemical<br />
<strong>Assessment</strong> Documents (CICADs)<br />
http://inchem.org/pages/cicads.html 2000 27/05/2009 TDI 0.00514 mg kg day 5.14 Unknown LOAEL 18 mg/m3 1000 10 <strong>for</strong> intraspecies variability, 10 <strong>for</strong><br />
interspecies variation and 10 <strong>for</strong> poor<br />
database and LOAEL use.<br />
Organisation <strong>for</strong> Economic Co-operation<br />
and Development (OECD) Screening<br />
In<strong>for</strong>mation Data Set (SIDS) <strong>for</strong> High<br />
Production Volume Chemicals<br />
http://inchem.org/pages/sids.html 2002 27/05/2009 TDI 1.2857 mg kg day 1285.7 Unknown NOAEL 450 mg/m3 100 10 <strong>for</strong> intraspecies variability, 10 <strong>for</strong><br />
interspecies variation. (Unknown,<br />
applied).<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATSDR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
http://www.atsdr.cdc.gov/ December 1998 28/05/2009 MRL 0.05 (0.028571) ppm (mg kg day) 28.57 Unknown LOAEL 51 ppm 1000 10 <strong>for</strong> intraspecies variability, 10 <strong>for</strong><br />
interspecies variation and 10 <strong>for</strong><br />
LOAEL<br />
Page 1 of 4 EIC pro<strong>for</strong>ma chloromethane 09/09/2009
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