Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloroethane TDI inhal Organisation Study type Description Target organ/Critical Effect Reference Web link Health and Safety Executive (HSE) Information not available WEL: workplace exposure limit MEL: maximum exposure limit EH40(2007 amendments) http://www.hse.gov.uk/coshh/table1.pdf http://www.hse.gov.uk/ria/chemical/chloro ethane.pdf US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) Derived from same study as RfC (see below) Mouse developmental inhalation study in CF-1 mice In a developmental study conducted in groups Delayed fetal ossification of 30 CF-1 mice, Scortichini et al. (1986) exposed animals to mean time-weighted averages of 0 (air), 491 +/-37 ppm (1.3 g/cu.m), 1504 +/- 84 ppm (4000 mg/cu.m), and 4946 +/- 159 ppm (13,000 mg/cu.m.) 99.9% ethyl chloride for 6 hours/day on days 6 through 15 of gestation. The animals were sacrificed on the 18th day of gestation. This study shows that exposure to ethyl chloride results in fetotoxicity. The exposure concentration of 1504 ppm is the NOAEL of this study NOAEL(HEC) = 4000 mg/cu.m based on foramina of the skull bones. The highest concentration used in this study, 4946 ppm, is a LOAEL, (HEC) = 13,000 mg/cu.m. Scortichini, B.H., K.A. Johnson, J.J. Momany-Pfruender, and T.R. Hanley, Jr. 1986. Ethyl chloride: Inhalation teratology study in CF-1 mice. Dow Chemical Co. EPA Document #86-870002248. 1986. US EPA IRIS Listing for Ethyl chloride (CASRN 75-00-3) http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_ mrls_december_2008.pdf http://www.epa.gov/iris/subst/0523.htm Toxicology Data Network (Toxnet) Information not available Information not available Information not available 30 CF-1 mice; chronic Mouse study (Scortichiniet al. 1986); 6-15 day duration Delayed fetal ossification http://toxnet.nlm.nih.gov/cgi-bin/sis/search RBCA Toolkit chemical database RISC 4 chemical database US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) US Army Corps Texas Commission on Environmental Quality Information not available Sub chronic Information not available Information not available Mouse study (Scortichiniet al. 1986); 6-15 day duration Value cited in ARAMS database (Adaptive Risk Assessment Modelling System); derived from IRIS Delayed fetal ossification USEPA Integrated Risk Information System( IRIS), as of March 31, 2007 USEPA Integrated Risk Information System( IRIS) Texas Risk Reduction Program, Toxicity and physical/chemical properties tables dated March 25, 2009 http://www.tceq.state.tx.us/assets/public/re mediation/trrp/trrptoxchph_032509.xls Page 4 of 4 EIC proforma chloroethane.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloroethane CAS: 75-00-3 Assessor A: Jane Thrasher (Jacobs) Assessor B: Andy Singleton (ESI) Final review: Panel/SF Date 29/04/2009 Date 30/04/2009 Date 26/08/2009 MDI Recommended MDIoral Units 0 ug day-1 Justification: No literature data available for background exposures (note: gaseous in nature - minimal oral intake anticipated) Organisation Date Media Value Units Description Reference Web link MDI Recommended MDIinh Units 13.5 ug day-1 Justification: Assume 13.5μd/day in absence of any reliable UK data. Only literature value relates to US research from 1980. Organisation Date Media Value Units Description Reference Web link Toxicological Data Network 20/04/2009 Air intake 2.4 to 13.5 ug/day ug/day Based on monitoring of four US cities (TOXNET) (average) in 1980. Singh HB et al; Atmospheric Measurements of Selected Hazardous Organic Chemicals. USEPA-600/S3-81-032 p. 4-5 (1981)] PEER REVIEWED http://toxnet.nlm.nih.gov/cgibin/sis/search/rdbs+hsdb:@term+@rn+75-00-3 Page 1 of 1 EIC proforma chloroethane.xls 26/08/2009
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