Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948<br />
Chloroethane<br />
TDI inhal<br />
Organisation<br />
Study type Description Target organ/Critical Effect Reference Web link<br />
<strong>Health</strong> and Safety Executive (HSE)<br />
In<strong>for</strong>mation not<br />
available<br />
WEL: workplace exposure limit<br />
MEL: maximum exposure limit<br />
EH40(2007 amendments)<br />
http://www.hse.gov.uk/coshh/table1.pdf<br />
http://www.hse.gov.uk/ria/chemical/chloro<br />
ethane.pdf<br />
US Agency <strong>for</strong> Toxic Substances and<br />
Disease Registry (ATSDR) Toxicological<br />
Profiles and Minimal <strong>Risk</strong> levels<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
Derived from<br />
same study as RfC<br />
(see below)<br />
Mouse<br />
developmental<br />
inhalation study<br />
in CF-1 mice<br />
In a developmental study conducted in groups Delayed fetal ossification<br />
of 30 CF-1 mice, Scortichini et al. (1986)<br />
exposed animals to mean time-weighted<br />
averages of 0 (air), 491 +/-37 ppm (1.3 g/cu.m),<br />
1504 +/- 84 ppm (4000 mg/cu.m), and 4946 +/-<br />
159 ppm (13,000 mg/cu.m.) 99.9% ethyl<br />
chloride <strong>for</strong> 6 hours/day on days 6 through 15<br />
of gestation. The animals were sacrificed on the<br />
18th day of gestation. This study shows that<br />
exposure to ethyl chloride results in<br />
fetotoxicity. The exposure concentration of<br />
1504 ppm is the NOAEL of this study<br />
NOAEL(HEC) = 4000 mg/cu.m based on<br />
<strong>for</strong>amina of the skull bones. The highest<br />
concentration used in this study, 4946 ppm, is a<br />
LOAEL, (HEC) = 13,000 mg/cu.m.<br />
Scortichini, B.H., K.A. Johnson, J.J. Momany-Pfruender, and T.R. Hanley, Jr.<br />
1986. Ethyl chloride: Inhalation teratology study in CF-1 mice. Dow<br />
Chemical Co. EPA Document #86-870002248. 1986. US EPA IRIS<br />
Listing <strong>for</strong> Ethyl chloride (CASRN 75-00-3)<br />
http://www.atsdr.cdc.gov/mrls/pdfs/atsdr_<br />
mrls_december_2008.pdf<br />
http://www.epa.gov/iris/subst/0523.htm<br />
Toxicology Data Network (Toxnet)<br />
In<strong>for</strong>mation not<br />
available<br />
In<strong>for</strong>mation not<br />
available<br />
In<strong>for</strong>mation not<br />
available<br />
30 CF-1 mice;<br />
chronic<br />
Mouse study (Scortichiniet al. 1986); 6-15 day<br />
duration<br />
Delayed fetal ossification<br />
http://toxnet.nlm.nih.gov/cgi-bin/sis/search<br />
RBCA Toolkit chemical database<br />
RISC 4 chemical database<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
US Army Corps<br />
Texas Commission on Environmental<br />
Quality<br />
In<strong>for</strong>mation not<br />
available<br />
Sub chronic<br />
In<strong>for</strong>mation not<br />
available<br />
In<strong>for</strong>mation not<br />
available<br />
Mouse study (Scortichiniet al. 1986); 6-15 day<br />
duration<br />
Value cited in ARAMS database (Adaptive <strong>Risk</strong><br />
<strong>Assessment</strong> Modelling System); derived from<br />
IRIS<br />
Delayed fetal ossification<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System( IRIS), as of March 31, 2007<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System( IRIS)<br />
Texas <strong>Risk</strong> Reduction Program, Toxicity and physical/chemical properties<br />
tables dated March 25, 2009<br />
http://www.tceq.state.tx.us/assets/public/re<br />
mediation/trrp/trrptoxchph_032509.xls<br />
Page 4 of 4 EIC pro<strong>for</strong>ma chloroethane.xls 26/08/2009
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