Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948<br />
Chloroethane CAS Number: 75-00-3<br />
TDI inhal<br />
Assessor A:<br />
Jane Thrasher<br />
(Jacobs)<br />
Assessor B:<br />
Andy Singleton<br />
(ESI)<br />
Final review: Panel/SF<br />
Date 29/04/2009 Date 30/04/2009 Date 26/08/2009<br />
Recommended<br />
TDIinhal Units<br />
2857 μg.kg-1.bw d-1<br />
Justification<br />
Adopt RfC of 10 mg/m3 (IRIS); adjusted to account <strong>for</strong> inhalation rate of 20 m3/d and 70kg body weight<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg-<br />
1.d-1<br />
Confidence<br />
rating<br />
Basis Value Units UF UF description<br />
<strong>Health</strong> and Safety Executive (HSE) http://www.hse.gov.uk/ EH40(2007<br />
amendments)<br />
US Agency <strong>for</strong> Toxic Substances and<br />
Disease Registry (ATSDR) Toxicological<br />
Profiles and Minimal <strong>Risk</strong> levels<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
15/04/2009 WEL and MEL WEL: 134<br />
(8 hr TWA)<br />
MEL: 50<br />
(8 hr TWA)<br />
http://www.atsdr.cdc.gov/ 20/04/2009 MRL (Minimal <strong>Risk</strong><br />
Level); acute<br />
exposure<br />
http://epa.gov/iris/ 04/01/1991 20/04/2009 RfC 10 mg/m3 2857 Medium NOAEL<br />
LOAEL<br />
15<br />
40<br />
mg/m3<br />
ppm<br />
ppm<br />
mg/m3<br />
4000<br />
13000<br />
mg/m3<br />
mg/m3<br />
300 A factor of 10 is used to account <strong>for</strong><br />
sensitive populations. An uncertainty<br />
factor of 3 (rather than 10) is used <strong>for</strong><br />
interspecies extrapolation due to<br />
dosimetric adjustment of the inhaled<br />
concentration. As no multigeneration<br />
reproductive study and no definitive<br />
developmental toxicity studies were<br />
available, a full factor of 10 is<br />
proposed <strong>for</strong> database deficiencies.<br />
Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ RfC verified<br />
20/12/1990<br />
20/04/2009<br />
TLV (Threshold Limit<br />
Value)<br />
PEL (Permissible<br />
Exposure Limit)<br />
IDLH (Immediately<br />
Dangerous to Life or<br />
<strong>Health</strong>)<br />
100<br />
260<br />
1000<br />
2600<br />
3800<br />
10200<br />
ppm<br />
mg/m3<br />
ppm<br />
mg/m3<br />
ppm<br />
mg/m3<br />
RfC 10 mg/m3 Medium NOAEL<br />
LOAEL<br />
4000<br />
13000<br />
mg/m3<br />
mg/m3<br />
300 A factor of 10 is used to account <strong>for</strong><br />
sensitive populations. An uncertainty<br />
factor of 3 (rather than 10) is used <strong>for</strong><br />
interspecies extrapolation due to<br />
dosimetric adjustment of the inhaled<br />
concentration<br />
RBCA Toolkit chemical database N/A Model version 2.01 20/04/2009 RfC/TCA 10 mg/m3<br />
RISC 4 chemical database Version 4.05 20/04/2009 RfC/slope factor N/D<br />
US EPA Provisional Peer Reviewed Toxicity http://rais.ornl.gov/tox/unauthorized.shtml Jul-07 21/04/2009 p-SRfC 4 mg/m3 Medium BMD/LEC 1078 mg/m3 300<br />
Values (PPRTV)<br />
US Army Corps<br />
US Army corps:<br />
http://el.erdc.usace.army.mil/arams/<br />
20/05/2009 RfD inhal 2.86 mg/kg/d<br />
Texas Commission on Environmental<br />
Quality<br />
Texas:<br />
http://www.tceq.state.tx.us/remediation/rr<br />
r.html<br />
25-Mar-09 20/05/2009 RfC 10 mg/m3<br />
Page 3 of 4 EIC pro<strong>for</strong>ma chloroethane.xls 26/08/2009
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