Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloroethane TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link International Agency for Research on Cancer (IARC) Not classifiable as human carcinogen (IARC) http://www.inchem.org/documents/iarc/vol71/075-chlorethane.html : Group 3 classification (The agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans) International Programme on Chemical Safety (IPCS) USEPA Integrated Risk Information System (IRIS) RBCA Toolkit chemical database US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) Source information not presented Information not presented US EPA National Center for Environmental Assessment (NCEA) Sub chronic Rat study (Dow 1995); 14 day duration Provisional Peer Reviewed Toxicity Values for Chloroethane, Superfund Health Risk Technical Support Center, National Center for Environmental Assessment, USEPA. 24/7/2007 none The existing database does not support the development of a chronic oral p-RFD because of the lack of 90 day chronic oral studies. none RAIS Chronic USEPA Region 9 /NCEA (National Centre for Environmental Assessment) Sub chronic Texas Commission on Environmental Quality Texas Risk Reduction Program, Toxicity and physical/chemical properties tables dated March 25, 2009 http://www.tceq.state.tx.us/assets/public/re mediation/trrp/trrptoxchph_032509.xls Page 2 of 4 EIC proforma chloroethane.xls 26/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Chloroethane CAS Number: 75-00-3 TDI inhal Assessor A: Jane Thrasher (Jacobs) Assessor B: Andy Singleton (ESI) Final review: Panel/SF Date 29/04/2009 Date 30/04/2009 Date 26/08/2009 Recommended TDIinhal Units 2857 μg.kg-1.bw d-1 Justification Adopt RfC of 10 mg/m3 (IRIS); adjusted to account for inhalation rate of 20 m3/d and 70kg body weight Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- 1.d-1 Confidence rating Basis Value Units UF UF description Health and Safety Executive (HSE) http://www.hse.gov.uk/ EH40(2007 amendments) US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels USEPA Integrated Risk Information System (IRIS) 15/04/2009 WEL and MEL WEL: 134 (8 hr TWA) MEL: 50 (8 hr TWA) http://www.atsdr.cdc.gov/ 20/04/2009 MRL (Minimal Risk Level); acute exposure http://epa.gov/iris/ 04/01/1991 20/04/2009 RfC 10 mg/m3 2857 Medium NOAEL LOAEL 15 40 mg/m3 ppm ppm mg/m3 4000 13000 mg/m3 mg/m3 300 A factor of 10 is used to account for sensitive populations. An uncertainty factor of 3 (rather than 10) is used for interspecies extrapolation due to dosimetric adjustment of the inhaled concentration. As no multigeneration reproductive study and no definitive developmental toxicity studies were available, a full factor of 10 is proposed for database deficiencies. Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ RfC verified 20/12/1990 20/04/2009 TLV (Threshold Limit Value) PEL (Permissible Exposure Limit) IDLH (Immediately Dangerous to Life or Health) 100 260 1000 2600 3800 10200 ppm mg/m3 ppm mg/m3 ppm mg/m3 RfC 10 mg/m3 Medium NOAEL LOAEL 4000 13000 mg/m3 mg/m3 300 A factor of 10 is used to account for sensitive populations. An uncertainty factor of 3 (rather than 10) is used for interspecies extrapolation due to dosimetric adjustment of the inhaled concentration RBCA Toolkit chemical database N/A Model version 2.01 20/04/2009 RfC/TCA 10 mg/m3 RISC 4 chemical database Version 4.05 20/04/2009 RfC/slope factor N/D US EPA Provisional Peer Reviewed Toxicity http://rais.ornl.gov/tox/unauthorized.shtml Jul-07 21/04/2009 p-SRfC 4 mg/m3 Medium BMD/LEC 1078 mg/m3 300 Values (PPRTV) US Army Corps US Army corps: http://el.erdc.usace.army.mil/arams/ 20/05/2009 RfD inhal 2.86 mg/kg/d Texas Commission on Environmental Quality Texas: http://www.tceq.state.tx.us/remediation/rr r.html 25-Mar-09 20/05/2009 RfC 10 mg/m3 Page 3 of 4 EIC proforma chloroethane.xls 26/08/2009
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