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Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

Soil Generic Assessment Criteria for Human Health Risk ... - ESdat Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Carbazole TDI oral Organisation Study type Description Target organ/Critical Effect Reference Web link European Chemicals Bureau (ECB) Scientific Committee on Food (SCF) pre 2002 International Agency for Research on Cancer (IARC) Joint Expert Committee on Food Additives (JECFA) US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) rat mice Acute oral toxicity data (report not in English). Quotes >16000 mg/kg bw and >5000 mg/kg bw (page 20). In a study by oral administration, a dosedependent increase in the incidence of liver neoplastic nodules and hepatocellular carcinomas was observed. Papillomas and carcinomas of the forestomach occurred in animals receiving the high-dose level. There is limited evidence that carbazole is carcinogenic to experimental animals. Skin liver and forestomach Iuclid dataset. European commission - European chemicals bureau. 19 February 2000. Commission recommendation of 19/09/2003 concerning the European schedule of occupational diseases http://ecb.jrc.ec.europa.eu/documents/Existing- Chemicals/IUCLID/DATA_SHEETS/91995163.pdf http://ec.europa.eu/employment_social/news/2003/sep/occdis_recc_en.pd f#xml=http://158.167.146.104:7001/www/xmlread.jspServerSpec=158.167. 146.104:9000&K2DocKey=http%3A%2F%2Fec.europa.eu%2Femployment_s ocial%2Fnews%2F2003%2Fsep%2Foccdis_recc_en.pdf%40EUROPACORE_ece u_x&QuetyText=carbazole http://www.inchem.org/documents/iarc/vol32/carbazole.html International Agency for Research on Cancer (IARC) - Summaries & Evaluations. Carbazole. VOL.: 32 (1983) (p. 239) Page 94 - IARC classification of carbazole (classed as level 3 - the compound is http://whqlibdoc.who.int/publications/2004/9241530626.pdf not classifiable as to its carcinogenicity to humans). Provisional Peer Reviewed Toxicity Values for Carbazole (CASRN 86-74-8). NA TDI inhal Organisation Study type Description Response Reference Web link US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) Provisional Peer Reviewed Toxicity Values for Carbazole (CASRN 86-74-8). NA ID oral Organisation Study type Description Response Reference Web link US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels Agency for toxic substances & disease registry- public health assessment. Reference to the EPA’s Oral Cancer Slope Factor (mg/kg/day)-1 - quotes 0.02. http://www.atsdr.cdc.gov/HAC/PHA/oakridge013107-TN/ceo_p4.html#t21 Page 2 of 4 EIC proforma carbazole WSP Fin Rev 12 Aug 09.xls28/08/2009

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Carbazole CAS Number: 86-74-8 Assessor A: Simon Clennell-Jones (WSP) Assessor B: Simon Tempest (ERM) Final review: Panel/SF Date 19/05/2009 Date 20/05/2009 Date 28/08/2009 USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ NR 14/05/2009 US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml 23/07/2008 NA Oral slope factor could not be derived due to lack of suitable oral data in humans or animals. PPRTV included a review of HEAST database. PRG region 9 http://www.epa.gov/region09/superfund/pr g/files/04prgtable.pdf Oct-04 18/05/2009 unknown Slope Factor Sourced from HEAST oral slope factor 0.02 (mg/kg/bw.day)-1 unknown The Risk Assessment Information System http://rais.ornl.gov/cgibin/tox/TOX_selectselect=chem 1986 18/05/2009 liver tumour Slope Factor Sourced from HEAST oral slope factor 0.02 (mg/kg/bw.day)-1 unknown Texas Commission on Environmental Quality. Texas Risk Reduction Program Protective Concentration Levels http://www.tceq.state.tx.us/remediation/trr p/trrppcls.html 26/03/2009 19/05/2009 unknown Slope Factor Sourced from HEAST oral slope factor 0.02 (mg/kg/bw.day)-1 unknown ID inhal Organisation US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml Last Updated 23/07/2008 NA Non threshold effects Recommended IDoral Units μg/kg/day Justification Insufficient data with sufficient detail to derive ID Basis Health criteria type Value Units Confidence rating Basis PRG region 9 http://www.epa.gov/region09/superfund/pr g/files/04prgtable.pdf Oct-04 18/05/2009 inhalation slope factor (extrapolated oral) 0.02 (mg/kg/bw.day)-1 unknown Page 3 of 4 EIC proforma carbazole WSP Fin Rev 12 Aug 09.xls28/08/2009

www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948<br />

Carbazole<br />

TDI oral<br />

Organisation<br />

Study type Description Target organ/Critical Effect Reference Web link<br />

European Chemicals Bureau (ECB)<br />

Scientific Committee on Food (SCF) pre 2002<br />

International Agency <strong>for</strong> Research on Cancer<br />

(IARC)<br />

Joint Expert Committee on Food Additives<br />

(JECFA)<br />

US EPA Provisional Peer Reviewed Toxicity<br />

Values (PPRTV)<br />

rat<br />

mice<br />

Acute oral toxicity data (report not in English).<br />

Quotes >16000 mg/kg bw and >5000 mg/kg bw<br />

(page 20).<br />

In a study by oral administration, a dosedependent<br />

increase in the incidence of liver<br />

neoplastic nodules and hepatocellular<br />

carcinomas was observed. Papillomas and<br />

carcinomas of the <strong>for</strong>estomach occurred in<br />

animals receiving the high-dose level. There is<br />

limited evidence that carbazole is carcinogenic<br />

to experimental animals.<br />

Skin<br />

liver and <strong>for</strong>estomach<br />

Iuclid dataset. European commission - European chemicals bureau. 19<br />

February 2000.<br />

Commission recommendation of 19/09/2003 concerning the European<br />

schedule of occupational diseases<br />

http://ecb.jrc.ec.europa.eu/documents/Existing-<br />

Chemicals/IUCLID/DATA_SHEETS/91995163.pdf<br />

http://ec.europa.eu/employment_social/news/2003/sep/occdis_recc_en.pd<br />

f#xml=http://158.167.146.104:7001/www/xmlread.jspServerSpec=158.167.<br />

146.104:9000&K2DocKey=http%3A%2F%2Fec.europa.eu%2Femployment_s<br />

ocial%2Fnews%2F2003%2Fsep%2Foccdis_recc_en.pdf%40EUROPACORE_ece<br />

u_x&QuetyText=carbazole<br />

http://www.inchem.org/documents/iarc/vol32/carbazole.html<br />

International Agency <strong>for</strong> Research on Cancer (IARC) - Summaries &<br />

Evaluations. Carbazole. VOL.: 32 (1983) (p. 239)<br />

Page 94 - IARC classification of carbazole (classed as level 3 - the compound is http://whqlibdoc.who.int/publications/2004/9241530626.pdf<br />

not classifiable as to its carcinogenicity to humans).<br />

Provisional Peer Reviewed Toxicity Values <strong>for</strong> Carbazole (CASRN 86-74-8). NA<br />

TDI inhal<br />

Organisation<br />

Study type Description Response Reference Web link<br />

US EPA Provisional Peer Reviewed Toxicity<br />

Values (PPRTV)<br />

Provisional Peer Reviewed Toxicity Values <strong>for</strong> Carbazole (CASRN 86-74-8).<br />

NA<br />

ID oral<br />

Organisation<br />

Study type Description Response Reference Web link<br />

US Agency <strong>for</strong> Toxic Substances and Disease<br />

Registry (ATDSR) Toxicological Profiles and<br />

Minimal <strong>Risk</strong> levels<br />

Agency <strong>for</strong> toxic substances & disease registry- public health assessment.<br />

Reference to the EPA’s Oral Cancer Slope Factor (mg/kg/day)-1 - quotes 0.02.<br />

http://www.atsdr.cdc.gov/HAC/PHA/oakridge013107-TN/ceo_p4.html#t21<br />

Page 2 of 4<br />

EIC pro<strong>for</strong>ma carbazole WSP Fin Rev 12 Aug 09.xls28/08/2009

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