Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Carbazole CAS Number: 86-74-8 Assessor A: Simon Clennell-Jones
(WSP)
Assessor B:
Simon Tempest
(ERM)
Final review:
Panel/SF
Date 19/05/2009 Date 20/05/2009 Date 28/08/2009
Oral
Dermal
Inhalation
Combine Oral
and Inhalation
TDIs
Justification
Apply TDIoral to exposure routes
No No No
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Yes Yes No
No No No
NR
Group 3 IARC Not classifiable as to its carcinogenicity to
humans. Group B2 USEPA Probably carcinogenic to humans
(little or no human data). Insufficient data with sufficient
details to derive TDIs or IDs.
Apply IDinh to exposure routes
No No Yes
TDI oral
Recommended TDIoral Units
μg/kg/day
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg-
1.d-1
European Chemicals Bureau (ECB) http://ecb.jrc.it/ NR 14/05/2009
Justification
Insufficient data with sufficient detail to derive TDI
Confidence rating Basis Value Units UF UF description
Scientific Committee on Food (SCF) pre 2002 http://ec.europa.eu/food/fs/sc/scf/index_en.
html
NR 14/05/2009
International Agency for Research on Cancer http://inchem.org/pages/iarc.html NR 14/05/2009
(IARC)
Joint Expert Committee on Food Additives
(JECFA)
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
http://who.int/ipcs/food/jecfa/en/ NR 18/05/2009
http://rais.ornl.gov/tox/unauthorized.shtml 23/07/2008 NA RFD PPRTV inadequate data to
derive a p-RfD
TDI inhal
Recommended
TDIinhal units CLEA Units ug.kgμg/kg/day
Justification
Insufficient data with sufficient detail to derive TDI
Organisation Last Updated Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description
1.d-1
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
http://rais.ornl.gov/tox/unauthorized.shtml 23/07/2008 NA RFC PPRTV No inhalation toxicity
data identified to
derive a p-RfC
ID oral Recommended IDoral Units
Justification
μg/kg/day Insufficient data with sufficient detail to derive ID
Organisation Last Updated Non threshold
effects
Basis Health criteria type Value Units Confidence rating Basis
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
http://www.atsdr.cdc.gov/ 12/03/2009 18/05/2009
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EIC proforma carbazole WSP Fin Rev 12 Aug 09.xls28/08/2009