Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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Butyl benzyl phthalate CAS Number: 85-68-7 Assessor A: N Struggles, AECOM Assessor B: Atkins Final review: Panel/SF<br />
Date 01/06/2009 Date 17/06/2009 Date 26/08/2009<br />
Apply TDIoral to exposure routes<br />
Apply IDoral to exposure routes<br />
Apply TDIinh to exposure routes<br />
Apply IDinh to exposure routes<br />
Oral<br />
Inhalation<br />
Dermal<br />
Yes Yes Yes<br />
No No No<br />
No No No<br />
No No No<br />
Combine Oral<br />
and Inhalation<br />
TDIs<br />
Yes<br />
Justification<br />
Insufficient data to assess non threshold effects - so<br />
HCV based on threshold effects<br />
Insufficient data to assess non threshold effects - so<br />
HCV based on threshold effects. Route to route<br />
extrapolation from oral HCV<br />
TDI oral<br />
Recommended TDIoral Units<br />
500 ug.kg-1.d-1<br />
Justification<br />
EFSA and Dutch RIVM most recent studies and report same value.<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description Study type<br />
1.d-1<br />
European Food Safety Authority (EFSA) http://www.efsa.europa.eu/en.html No data 01/06/2009 TDI 0.5 mg/kg bw/day 500 n/a NOAEL 50 mg/kg bw/day 100 10 each <strong>for</strong> inter and intraspecies<br />
differences (EFSA)<br />
Rat, oral<br />
IPCS concise International Chemical <strong>Assessment</strong> Documents (CICADs) http://inchem.org/pages/cicads.html 01/01/1999 01/06/2009 TDI oral 1.3 mg.kgbw-1.d-1 1300 Medium Benchmark Dose 132 mg.kgbw-1.d-1 100 Inter and Intra species variation Subchronic<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and the Environment (RIVM)<br />
Maximum Permissible <strong>Risk</strong> (MPR) levels.<br />
http://www.rivm.nl/en/ 01/03/2001 01/06/2009 TDI oral 500 ug.kgbw-1.d-1 500 Medium NOAEL 151 mg.kg-1.d-1 300 Inter and Intra species variation Subchronic<br />
<strong>Health</strong> Canada Toxicological Values http://www.hc-sc.gc.ca/index_e.html 25/03/2009 Benchmark Dose 1.3 mg/kg bw/day 1300 Moderate to high lower 95th<br />
confidence<br />
interval of<br />
Benchmark Dose<br />
132 mg/kg bw/day 100 Inter and intraspecies variations (10<br />
each) (<strong>Health</strong> Canada)<br />
Subchronic<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System (IRIS) http://epa.gov/iris/ 01/02/1993 01/06/2009 RfD 0.2 mg.kg-1.d-1 200 Medium NOAEL 159 mg.kg-1.d-1 1000 10 <strong>for</strong> intraspecies sensitivity, 10 <strong>for</strong><br />
interspecies variability and 10 <strong>for</strong><br />
extrapolating from subchronic to<br />
chronic NOAEL.<br />
Repeat dose<br />
study<br />
US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml 01/10/2002 n/a Provisional Oral Slope Factor 0.0019 mg/kg-day n/a n/a n/a n/a n/a n/a n/a Rat, oral<br />
TDI inhal<br />
Recommended<br />
TDIinhal<br />
Units<br />
Justification<br />
Insufficient data with sufficient detail on derivation to derive a TDIinhal. Use route-to-route extrapolation from oral.<br />
Organisation Web Link Last Updated Date Web Checked <strong>Health</strong> criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description Study type<br />
1.d-1<br />
IPCS concise International Chemical <strong>Assessment</strong> Documents (CICADs) http://inchem.org/pages/cicads.html 1999 25/03/2009 none 51 mg/m3 Rat, inhalation<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong> and the Environment (RIVM)<br />
Maximum Permissible <strong>Risk</strong> (MPR) levels<br />
http://www.rivm.nl/en/ 01/03/2001 01/06/2009 Due to low volatility of<br />
BBP inhalation<br />
exposure is considered<br />
not relevant<br />
Page 1 of 4 EIC pro<strong>for</strong>ma butyl benzyl phthalate.xls 26/08/2009