Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Bromoform TDI oral Organisation Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) International Programme on Chemical Safety (IPCS) Study type Description Target organ/Critical Effect Reference Web link Animal unknown liver toxicity Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment, TOX/2001/16 - A Sahsu Study on Chlorination Disinfection By-Products and Birth Outcomes in 3 Water Areas in England, 2001 (For members use only) http://cot.food.gov.uk/pdfs/tox200116.pdf 13 weeks after Rats Absence of Liver Lesions IPCS, Environmental Health Criteria 216 - Environmental Health Criteria for dosing by corn oil Disinfectants and Disinfectant By-Products, 2000 gavage http://www.inchem.org/documents/ehc/ehc/ehc216.htm WHO Guidelines for drinking water Quality 90 days Rats absence of histopathological lesions in the liver WHO, Guidelines for Drinking Water Quality, 2008 http://www.who.int/water_sanitation_health/dwq/2edvol1c.pdf Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels 7 days/week for 13 weeks Rats Hepatic Lesions Janssen et al. Maximum Permissible Risk Levels for Human Intake of Soil Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004. March 1998. http://www.rivm.nl/bibliotheek/rapporten/601501027.html http://rivm.openrepository.com/rivm/bitstream/10029/10310/1/71170100 4.pdf US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels USEPA Health Advisors short duration - Corn oil 5 days/week for 13 weeks Intermediate duration - Corn oil 5 days/week for 13 weeks 5 days/week for 13 weeks (subchronic) rats Minimal to moderate liver and kidney histological alterations were observed ATSDR, Toxicological Profile for Bromoform and Dibromochloromethane, 2005 Rats hepatocellular vacuolization ATSDR, Toxicological Profile for Bromoform and Dibromochloromethane, 2005 Rats, gavage in corn oil histopathological changes (vacuolization) in the liver. EPA Office of Water, Drinking Water Criteria Document for Brominated Trihalomethanes, 2005 http://www.atsdr.cdc.gov/toxprofiles/tp130.pdf http://www.atsdr.cdc.gov/toxprofiles/tp130.pdf http://www.epa.gov/waterscience/criteria/drinking/brthm- 200605(508).pdf USEPA Integrated Risk Information System (IRIS) 5 days/week for 13 weeks (subchronic) Rat, Gavage Bioassay Hepatic Lesions IRIS online database. Last updated in 1989 http://www.epa.gov/ncea/iris/subst/0214.htm US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) 13 week study male rates hepatocellular vacuolization Superfund Health Risk Technical Support Centre, Provisonal Peer Reviewed Toxicity Values for Bromoform (2005) n/a Toxicology Data Network (Toxnet) 13 week, subchronic Rats, Gavage Study Liver Lesions Bromoform - Anonymous (1997) http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~cnjaJs:1 TDI inhal Organisation Study type Description Response Reference Web link Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels Animal Study only accounts for systemic effects of inhalation and is derived from oral TDI Janssen et al. Maximum Permissible Risk Levels for Human Intake of Soil Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004. March 1998. http://rivm.openrepository.com/rivm/bitstream/10029/10310/1/71170100 4.pdf Page 3 of 4 EIC proforma bromoform.xls 28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Bromoform ID oral Organisation Study type Description Response Reference Web link USEPA Integrated Risk Information System (IRIS) animal (rat) carcinogenesis rates. Test Species: F344/N rat, female by gavage in corn oil Tumor Type: Neoplastic lesions in the large intestine IRIS online database. Last updated in 1993 http://cfpub.epa.gov/ncea/iris/index.cfmfuseaction=iris.showQuickView& substance_nmbr=0214#carc ID inhal Organisation Study type Description Response Reference Web link USEPA Integrated Risk Information System (IRIS) animal (rat) carcinogenesis rates. Test Species: F344/N rat, female by gavage in corn oil Tumor Type: Neoplastic lesions in the large intestine IRIS online database. Last updated in 1993 http://cfpub.epa.gov/ncea/iris/index.cfmfuseaction=iris.showQuickView& substance_nmbr=0214#carc Page 4 of 4 EIC proforma bromoform.xls 28/08/2009
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