Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
Soil Generic Assessment Criteria for Human Health Risk ... - ESdat
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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948<br />
Bromo<strong>for</strong>m<br />
TDI oral<br />
Organisation<br />
Committee on the Toxicity of Chemicals in<br />
Food, Consumer Products and the<br />
Environment (COT)<br />
International Programme on Chemical<br />
Safety (IPCS)<br />
Study type Description Target organ/Critical Effect Reference Web link<br />
Animal unknown liver toxicity Committee on the Toxicity of Chemicals in Food, Consumer Products and<br />
the Environment, TOX/2001/16 - A Sahsu Study on Chlorination Disinfection<br />
By-Products and Birth Outcomes in 3 Water Areas in England, 2001 (For<br />
members use only)<br />
http://cot.food.gov.uk/pdfs/tox200116.pdf<br />
13 weeks after Rats Absence of Liver Lesions IPCS, Environmental <strong>Health</strong> <strong>Criteria</strong> 216 - Environmental <strong>Health</strong> <strong>Criteria</strong> <strong>for</strong><br />
dosing by corn oil<br />
Disinfectants and Disinfectant By-Products, 2000<br />
gavage<br />
http://www.inchem.org/documents/ehc/ehc/ehc216.htm<br />
WHO Guidelines <strong>for</strong> drinking water Quality<br />
90 days Rats absence of histopathological lesions in the<br />
liver<br />
WHO, Guidelines <strong>for</strong> Drinking Water Quality, 2008<br />
http://www.who.int/water_sanitation_health/dwq/2edvol1c.pdf<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong><br />
and the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
7 days/week <strong>for</strong><br />
13 weeks<br />
Rats Hepatic Lesions Janssen et al. Maximum Permissible <strong>Risk</strong> Levels <strong>for</strong> <strong>Human</strong> Intake of <strong>Soil</strong><br />
Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004.<br />
March 1998.<br />
http://www.rivm.nl/bibliotheek/rapporten/601501027.html<br />
http://rivm.openrepository.com/rivm/bitstream/10029/10310/1/71170100<br />
4.pdf<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATDSR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
US Agency <strong>for</strong> Toxic Substances and Disease<br />
Registry (ATSDR) Toxicological Profiles and<br />
Minimal <strong>Risk</strong> levels<br />
USEPA <strong>Health</strong> Advisors<br />
short duration -<br />
Corn oil 5<br />
days/week <strong>for</strong> 13<br />
weeks<br />
Intermediate<br />
duration - Corn oil<br />
5 days/week <strong>for</strong><br />
13 weeks<br />
5 days/week <strong>for</strong><br />
13 weeks<br />
(subchronic)<br />
rats<br />
Minimal to moderate liver and kidney<br />
histological alterations were observed<br />
ATSDR, Toxicological Profile <strong>for</strong> Bromo<strong>for</strong>m and Dibromochloromethane,<br />
2005<br />
Rats hepatocellular vacuolization ATSDR, Toxicological Profile <strong>for</strong> Bromo<strong>for</strong>m and Dibromochloromethane,<br />
2005<br />
Rats, gavage in corn oil<br />
histopathological changes (vacuolization)<br />
in the liver.<br />
EPA Office of Water, Drinking Water <strong>Criteria</strong> Document <strong>for</strong> Brominated<br />
Trihalomethanes, 2005<br />
http://www.atsdr.cdc.gov/toxprofiles/tp130.pdf<br />
http://www.atsdr.cdc.gov/toxprofiles/tp130.pdf<br />
http://www.epa.gov/waterscience/criteria/drinking/brthm-<br />
200605(508).pdf<br />
USEPA Integrated <strong>Risk</strong> In<strong>for</strong>mation System<br />
(IRIS)<br />
5 days/week <strong>for</strong><br />
13 weeks<br />
(subchronic)<br />
Rat, Gavage Bioassay Hepatic Lesions IRIS online database. Last updated in 1989 http://www.epa.gov/ncea/iris/subst/0214.htm<br />
US EPA Provisional Peer Reviewed Toxicity<br />
Values (PPRTV)<br />
13 week study male rates hepatocellular vacuolization Superfund <strong>Health</strong> <strong>Risk</strong> Technical Support Centre, Provisonal Peer Reviewed<br />
Toxicity Values <strong>for</strong> Bromo<strong>for</strong>m (2005)<br />
n/a<br />
Toxicology Data Network (Toxnet)<br />
13 week,<br />
subchronic<br />
Rats, Gavage Study Liver Lesions Bromo<strong>for</strong>m - Anonymous (1997) http://toxnet.nlm.nih.gov/cgi-bin/sis/search/f./temp/~cnjaJs:1<br />
TDI inhal<br />
Organisation<br />
Study type Description Response Reference Web link<br />
Dutch National Institute <strong>for</strong> Public <strong>Health</strong><br />
and the Environment (RIVM) Maximum<br />
Permissible <strong>Risk</strong> (MPR) levels<br />
Animal Study<br />
only accounts <strong>for</strong> systemic effects of inhalation<br />
and is derived from oral TDI<br />
Janssen et al. Maximum Permissible <strong>Risk</strong> Levels <strong>for</strong> <strong>Human</strong> Intake of <strong>Soil</strong><br />
Contaminants: Fourth Series of Compounds. RIVM Report No. 711701004.<br />
March 1998.<br />
http://rivm.openrepository.com/rivm/bitstream/10029/10310/1/71170100<br />
4.pdf<br />
Page 3 of 4 EIC pro<strong>for</strong>ma bromo<strong>for</strong>m.xls 28/08/2009
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