Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Bromoform CAS Number: 75-25-2 Assessor A: J Brown - DTS Raeburn Assessor B: A Fellows - Final review: Panel/SF Ecologia Date 03/04/2009 Date 06/04/2009 Date 28/08/2009 Apply TDIoral to exposure routes Apply IDoral to exposure routes Apply TDIinh to exposure routes Apply IDinh to exposure routes Oral Inhalation Dermal Yes Yes Yes No No No No No No No No No Combine Oral and Inhalation TDIs NR Justification Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen - TDIoral applied to oral and dermal routes Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen. Insufficient data on inhalation toxicity to derive TDIinhal. TDIoral applied to inhalation routes. TDI oral Recommended TDIoral Units 20 ug.kg-1.d-1 Justification Most conservative value with good agreement between sources (WHO rounded up value, RIVM and USEPA IRIS) Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description 1.d-1 Committee on the Toxicity of Chemicals in Food, Consumer Products and the Environment (COT) http://cot.food.gov.uk/ 2001 09/04/2009 no data no data no data no data no data no data 25 mg/kg-day no data no data International Programme on Chemical Safety (IPCS) WHO Guidelines for drinking water Quality Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels US Agency for Toxic Substances and Disease Registry (ATDSR) Toxicological Profiles and Minimal Risk levels US Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles and Minimal Risk levels http://www.who.int/ipcs/en/ 2000 05/04/2009 TDI 25 μg/kg 25 no data NOAEL 25 mg/kg bw/day 1000 10 each for inter- and intraspecies variation and 10 for the short duration of the study and possible carcinogenicity http://www.who.int/water_sanitation_healt h/dwq/guidelines/en 2008 08/04/2009 TDI 25 μg/kg bw 5 days/week 17.9 no data NOAEL 25 mg/kg bw/day 1000 100 for intra and interspecies variation and 10 for possible carcinogenicity and short duration of the study http://www.rivm.nl/en/ 2005 09/04/2009 TDI 20 μg/kg bw/day 20 no data NOAEL 20 mg/kg bw/day 1000 factor of 10 for use of a subchronic assay, 10 for extrapolation of animal data to humans, factor 10 for the protection of sensitive human sub population. http://www.atsdr.cdc.gov/ Aug-05 06/04/2009 MRL acute 0.7 mg/kg/day 700 no data NOAEL 72 mg/kg/day 100 10 for animal to human extrapolation and 10 for human variability http://www.atsdr.cdc.gov/ Aug-05 06/04/2009 MRL intermediate 0.2 mg/kg/day 200 no data NOAEL 18 mg/kg/day 100 10 for animal to human extrapolation and 10 for human variability USEPA Health Advisors http://www.epa.gov/waterscience/criteria/d rinking 2005 09/04/2009 RfD 0.03 mg/kg-day 30 no data NOAEL 25 mg/kg-day 100 Composite uncertainty factor based on NAS/OW guidelines; includes a factor of 10 for interspecies variation, a factor of 10 for protection of sensitive human populations USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 1989 08/04/2009 RfD 0.02 mg/kg/day 20 Medium NOAEL 25 mg/kg-day 1000 Factors of 10 were employed for use of a subchronic assay, for extrapolation from animal data, and for protection of sensitive human subpopulation. US EPA Provisional Peer Reviewed Toxicity Values (PPRTV) http://rais.ornl.gov/tox/unauthorized.shtml 2005 03/08/2009 subchronic RfD 0.03 mg/kg/day 30 no data BMDL 2.6 mg/kg/day 100 10 for animal to human extrapolation and 10 for human variability Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ 1997 09/04/2009 Oral 0.2 mg/kg/day 200 no data no data no data no data no data no data TDI inhal Recommended TDIinhal Units ug.kg-1.d-1 Justification Insufficient data on inhalation pathway to derive TDI inhal. Route to route extrapolation from oral TDI applied. Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description 1.d-1 Dutch National Institute for Public Health and the Environment (RIVM) Maximum Permissible Risk (MPR) levels http://www.rivm.nl/en/ 2005 09/04/2009 TCA 100 μg/m³ 28.57 no data no data no data no data no data Already applied Page 1 of 4 EIC proforma bromoform.xls 28/08/2009
www.esdat.net Esdat Environmental Database Management Software +61 2 8875 7948 Bromoform CAS Number: 75-25-2 Assessor A: J Brown - DTS Raeburn Assessor B: A Fellows - Final review: Panel/SF Ecologia Date 03/04/2009 Date 06/04/2009 Date 28/08/2009 ID oral Recommended IDoral Units n/a Justification Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen Organisation Web Link Last Updated Date Web Checked Non threshold effects USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 01/01/1991 09/04/2009 B2 - probable human carcinogen Basis Based on inadequate human data and sufficient evidence of carcinogenicity in animals Health criteria type oral slope factor Value Units 0.0079 mg/kg/day Confidence rating Basis Extrapolation Method — Linearized multistage procedure, extra risk ID inhal Recommended IDinhal n/a Units Justification Group 3 carcinogen (IARC), no strong evidence to be a human carcinogen Organisation Web Link Last Updated Date Web Checked Non threshold effects USEPA Integrated Risk Information System (IRIS) http://epa.gov/iris/ 01/01/1991 09/04/2009 B2 - probable human carcinogen Basis Based on inadequate human data and sufficient evidence of carcinogenicity in animals Health criteria type oral slope factor Value Units 0.0000011 mg/kg/day Confidence rating Basis Extrapolation Method — Linearized multistage procedure, extra risk Page 2 of 4 EIC proforma bromoform.xls 28/08/2009
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