Soil Generic Assessment Criteria for Human Health Risk ... - ESdat

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Bromoform CAS Number: 75-25-2 Assessor A: J Brown - DTS Raeburn Assessor B: A Fellows - Final review: Panel/SF
Ecologia
Date 03/04/2009 Date 06/04/2009 Date 28/08/2009
Apply TDIoral to exposure routes
Apply IDoral to exposure routes
Apply TDIinh to exposure routes
Apply IDinh to exposure routes
Oral
Inhalation
Dermal
Yes Yes Yes
No No No
No No No
No No No
Combine Oral
and Inhalation
TDIs
NR
Justification
Group 3 carcinogen (IARC), no strong evidence to be
a human carcinogen - TDIoral applied to oral and
dermal routes
Group 3 carcinogen (IARC), no strong evidence to be
a human carcinogen. Insufficient data on inhalation
toxicity to derive TDIinhal. TDIoral applied to
inhalation routes.
TDI oral
Recommended
TDIoral
Units
20 ug.kg-1.d-1
Justification
Most conservative value with good agreement between sources (WHO rounded up value, RIVM and USEPA IRIS)
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description
1.d-1
Committee on the Toxicity of Chemicals in
Food, Consumer Products and the
Environment (COT)
http://cot.food.gov.uk/ 2001 09/04/2009 no data no data no data no data no data no data 25 mg/kg-day no data no data
International Programme on Chemical
Safety (IPCS)
WHO Guidelines for drinking water Quality
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
US Agency for Toxic Substances and Disease
Registry (ATDSR) Toxicological Profiles and
Minimal Risk levels
US Agency for Toxic Substances and Disease
Registry (ATSDR) Toxicological Profiles and
Minimal Risk levels
http://www.who.int/ipcs/en/ 2000 05/04/2009 TDI 25 μg/kg 25 no data NOAEL 25 mg/kg bw/day 1000 10 each for inter- and intraspecies
variation and 10 for the short
duration of the study and possible
carcinogenicity
http://www.who.int/water_sanitation_healt
h/dwq/guidelines/en
2008 08/04/2009 TDI 25 μg/kg bw 5
days/week
17.9 no data NOAEL 25 mg/kg bw/day 1000 100 for intra and interspecies
variation and 10 for possible
carcinogenicity and short duration of
the study
http://www.rivm.nl/en/ 2005 09/04/2009 TDI 20 μg/kg bw/day 20 no data NOAEL 20 mg/kg bw/day 1000 factor of 10 for use of a subchronic
assay, 10 for extrapolation of animal
data to humans, factor 10 for the
protection of sensitive human sub
population.
http://www.atsdr.cdc.gov/ Aug-05 06/04/2009 MRL acute 0.7 mg/kg/day 700 no data NOAEL 72 mg/kg/day 100 10 for animal to human extrapolation
and 10 for human variability
http://www.atsdr.cdc.gov/ Aug-05 06/04/2009 MRL intermediate 0.2 mg/kg/day 200 no data NOAEL 18 mg/kg/day 100 10 for animal to human extrapolation
and 10 for human variability
USEPA Health Advisors
http://www.epa.gov/waterscience/criteria/d
rinking
2005 09/04/2009 RfD 0.03 mg/kg-day 30 no data NOAEL 25 mg/kg-day 100 Composite uncertainty factor based
on NAS/OW guidelines; includes a
factor of 10 for interspecies variation,
a factor of 10 for protection of
sensitive human populations
USEPA Integrated Risk Information System
(IRIS)
http://epa.gov/iris/ 1989 08/04/2009 RfD 0.02 mg/kg/day 20 Medium NOAEL 25 mg/kg-day 1000 Factors of 10 were employed for use
of a subchronic assay, for
extrapolation from animal data, and
for protection of sensitive human
subpopulation.
US EPA Provisional Peer Reviewed Toxicity
Values (PPRTV)
http://rais.ornl.gov/tox/unauthorized.shtml 2005 03/08/2009 subchronic RfD 0.03 mg/kg/day 30 no data BMDL 2.6 mg/kg/day 100 10 for animal to human extrapolation
and 10 for human variability
Toxicology Data Network (Toxnet) http://toxnet.nlm.nih.gov/ 1997 09/04/2009 Oral 0.2 mg/kg/day 200 no data no data no data no data no data no data
TDI inhal
Recommended
TDIinhal
Units
ug.kg-1.d-1
Justification
Insufficient data on inhalation pathway to derive TDI inhal. Route to route extrapolation from oral TDI applied.
Organisation Web Link Last Updated Date Web Checked Health criteria type Value Initial Units CLEA units ug.kg- Confidence rating Basis Value Units UF UF description
1.d-1
Dutch National Institute for Public Health
and the Environment (RIVM) Maximum
Permissible Risk (MPR) levels
http://www.rivm.nl/en/ 2005 09/04/2009 TCA 100 μg/m³ 28.57 no data no data no data no data no data Already applied
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